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- W4361840837 abstract "Objectives: The aim of this work is to assess the suitability of Parkia biglobosa mucilage (PBM) as a suspending agent in metronidazole suspension. Methods and Materials: Metronidazole suspension was formulated with mucilage (0.1%, 0.5%, 1%, and 2% w /v) from P. biglobosa seeds as the suspending agent. Similar suspensions of metronidazole that contained (0.1%, 0.5%, 1%, and 2% w /v) tragacanth or gelatin were also prepared for comparison to PBM-based formulations. The suspensions were assessed for rheological properties, sedimentation volume, degree of flocculation, ease of redispersion, flow rate (flowability), and drug-excipient compatibility using Fourier-transform infrared spectroscopy. Results: Brownish metronidazole suspensions with a smooth and elegant appearance were obtained. After 2 weeks of storage at ambient temperature (28 ± 2 ° C), the ease of redispersion was in the following order: tragacanth < PBM < gelatin-containing formulations. The optimal pH of the formulation was slightly acidic and did not significantly change ( p > 0.05) after 3 months of storage at ambient temperature (28 ± 2°C). However, the viscosity of the formulations was reduced by more than 30%, and the flow rate was significantly increased ( P < 0.05). Suspensions formulated with 2% PBM were well-flocculated and easily redispersible. Furthermore, the sedimentation volume and sedimentation rate of suspensions formulated with 2% PBM were comparable to that of tragacanth- and gelatin-containing suspensions. Conclusion: PBM hence has great promise as a suspending agent for pharmaceutical preparations." @default.
- W4361840837 created "2023-04-05" @default.
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- W4361840837 date "2023-03-31" @default.
- W4361840837 modified "2023-10-06" @default.
- W4361840837 title "Evaluation of the suspending properties of <i>Parkia biglobosa</i> mucilage in a metronidazole suspension formulation" @default.
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- W4361840837 doi "https://doi.org/10.25259/ajpps_2023_004" @default.
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