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- W4361846476 abstract "<p>Figure S6. ARF6-GDP inhibits PI3K-AKT activation and is necessary for AKT activation. (a-b) Quantification of western blots shown in Figure 5c-d. Reproducible reduction in pAKT by Myc-ARF6T27N over expression in A375 cells (n=4), A2058 cells (n=4), and HEY-T30 cells (n=5). Reduced pAKT with siRNA knockdown of ARF6 in SK-MEL-147 (n=5), A2058 (n=4), and CACL (n=4) and HEY-T30 (n=6). Graphs show individual data points normalized to control along with geometric means, 95% CI, ratio paired t test. (c) Phosphokinase array images (left) and quantification of signal by densitometry (right, histogram), n=1. Expression of ARF6T27N in A2058 cells preferentially reduced pAKT and the AKT substrate PRAS40 over most other proteins in the array.</p>" @default.
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- W4361846476 date "2023-03-31" @default.
- W4361846476 modified "2023-10-16" @default.
- W4361846476 title "Figure S6 from The Small GTPase ARF6 Activates PI3K in Melanoma to Induce a Prometastatic State" @default.
- W4361846476 doi "https://doi.org/10.1158/0008-5472.22420617" @default.
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