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- W4361846515 abstract "<p>PDF file - 3065K, Figure S1. Average delay of growth of PDXs among passages (up to P5). Figure S2. DNA copy number variations found in the original primary tumors are well maintained in PDXs. Figure S3. Example of stromal dilution in parental primary tumor CRCM184 PT compared to paired CRCM 184 X. Figure S4. ALDEFLUOR phenotype of our 20 PDX models. Figure S5. Outgrowth kinetic of each sorted cell population isolated from three PDXs and injected in limited dilutions in fat pads of NSG mice. Figure S6. Univariate and multivariate analysis identified primary tumor engrafment as independent parameter associated with metastasis-free survival (MFS) in the series of 74 patients. Figure S7. Identification of parameters that predict successful engraftment. Figure S8. Global gene expression profiling of 53 PDXs. Figure S9. Supervised analyses of aCGH data comparing copy number variations in 17 paired primary tumors/PDXs. Figure S10. Representative network of genes isolated from the BCSC-GES and involved in DNA damage repair. Figure S11. Representative network of genes isolated from the BCSC-GES and involved in cell cycle control. Figure S12. The ?common? stem cell core transcriptional program (CE-4SC) is associated with clinical outcome. Figure S13. Functional validation of the CE-4SC in two different breast cancer cell lines (BCLs). Figure S14. Knock-down of genes from the CE-4SC affect tumorsphere-forming efficiency (SFE) in S68 BCL.</p>" @default.
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- W4361846515 date "2023-03-30" @default.
- W4361846515 modified "2023-10-17" @default.
- W4361846515 title "Supplementary Figures 1 - 14 from ALDH1-Positive Cancer Stem Cells Predict Engraftment of Primary Breast Tumors and Are Governed by a Common Stem Cell Program" @default.
- W4361846515 doi "https://doi.org/10.1158/0008-5472.22397655.v1" @default.
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