Matches in SemOpenAlex for { <https://semopenalex.org/work/W4361866475> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W4361866475 endingPage "528" @default.
- W4361866475 startingPage "523" @default.
- W4361866475 abstract "Recently, several groups made a nearly simultaneous discovery that autophagic degradation represents a previously unrecognized effector of innate and adaptive immunity. Despite the fact that hints to these phenomena hail back to earlier sporadic reports, autophagy has, until now, received attention primarily as a fundamental cellular homeostasis pathway, whereby cytoplasm portions get sequestered by the membrane for delivery to lysosomes. This process leads to the removal of damaged or surplus organelles and digests stable, long-lived macromolecules. Autophagy has been implicated previously in both health-promoting and disease-associated states, in cancer, neurodegeneration, development and aging. A protective role has recently been demonstrated in infectious diseases, which represents a previously unrecognized immune mechanism acting against intracellular microbes. This review reviews autophagy as an immune mechanism. Recently, several groups made a nearly simultaneous discovery that autophagic degradation represents a previously unrecognized effector of innate and adaptive immunity. Despite the fact that hints to these phenomena hail back to earlier sporadic reports, autophagy has, until now, received attention primarily as a fundamental cellular homeostasis pathway, whereby cytoplasm portions get sequestered by the membrane for delivery to lysosomes. This process leads to the removal of damaged or surplus organelles and digests stable, long-lived macromolecules. Autophagy has been implicated previously in both health-promoting and disease-associated states, in cancer, neurodegeneration, development and aging. A protective role has recently been demonstrated in infectious diseases, which represents a previously unrecognized immune mechanism acting against intracellular microbes. This review reviews autophagy as an immune mechanism." @default.
- W4361866475 created "2023-04-05" @default.
- W4361866475 creator A5076820187 @default.
- W4361866475 date "2005-10-01" @default.
- W4361866475 modified "2023-10-06" @default.
- W4361866475 title "Autophagy in innate and adaptive immunity" @default.
- W4361866475 doi "https://doi.org/10.1016/j.it.2005.08.003" @default.
- W4361866475 hasPublicationYear "2005" @default.
- W4361866475 type Work @default.
- W4361866475 citedByCount "132" @default.
- W4361866475 countsByYear W43618664752012 @default.
- W4361866475 countsByYear W43618664752013 @default.
- W4361866475 countsByYear W43618664752014 @default.
- W4361866475 countsByYear W43618664752015 @default.
- W4361866475 countsByYear W43618664752016 @default.
- W4361866475 countsByYear W43618664752017 @default.
- W4361866475 countsByYear W43618664752018 @default.
- W4361866475 countsByYear W43618664752019 @default.
- W4361866475 countsByYear W43618664752020 @default.
- W4361866475 countsByYear W43618664752021 @default.
- W4361866475 countsByYear W43618664752022 @default.
- W4361866475 countsByYear W43618664752023 @default.
- W4361866475 crossrefType "journal-article" @default.
- W4361866475 hasAuthorship W4361866475A5076820187 @default.
- W4361866475 hasConcept C111472728 @default.
- W4361866475 hasConcept C136449434 @default.
- W4361866475 hasConcept C138885662 @default.
- W4361866475 hasConcept C142724271 @default.
- W4361866475 hasConcept C190283241 @default.
- W4361866475 hasConcept C193419808 @default.
- W4361866475 hasConcept C203014093 @default.
- W4361866475 hasConcept C203522944 @default.
- W4361866475 hasConcept C2776925932 @default.
- W4361866475 hasConcept C2779134260 @default.
- W4361866475 hasConcept C2779341262 @default.
- W4361866475 hasConcept C51785407 @default.
- W4361866475 hasConcept C54355233 @default.
- W4361866475 hasConcept C71924100 @default.
- W4361866475 hasConcept C86803240 @default.
- W4361866475 hasConcept C8891405 @default.
- W4361866475 hasConcept C89611455 @default.
- W4361866475 hasConcept C95444343 @default.
- W4361866475 hasConceptScore W4361866475C111472728 @default.
- W4361866475 hasConceptScore W4361866475C136449434 @default.
- W4361866475 hasConceptScore W4361866475C138885662 @default.
- W4361866475 hasConceptScore W4361866475C142724271 @default.
- W4361866475 hasConceptScore W4361866475C190283241 @default.
- W4361866475 hasConceptScore W4361866475C193419808 @default.
- W4361866475 hasConceptScore W4361866475C203014093 @default.
- W4361866475 hasConceptScore W4361866475C203522944 @default.
- W4361866475 hasConceptScore W4361866475C2776925932 @default.
- W4361866475 hasConceptScore W4361866475C2779134260 @default.
- W4361866475 hasConceptScore W4361866475C2779341262 @default.
- W4361866475 hasConceptScore W4361866475C51785407 @default.
- W4361866475 hasConceptScore W4361866475C54355233 @default.
- W4361866475 hasConceptScore W4361866475C71924100 @default.
- W4361866475 hasConceptScore W4361866475C86803240 @default.
- W4361866475 hasConceptScore W4361866475C8891405 @default.
- W4361866475 hasConceptScore W4361866475C89611455 @default.
- W4361866475 hasConceptScore W4361866475C95444343 @default.
- W4361866475 hasIssue "10" @default.
- W4361866475 hasLocation W43618664751 @default.
- W4361866475 hasOpenAccess W4361866475 @default.
- W4361866475 hasPrimaryLocation W43618664751 @default.
- W4361866475 hasRelatedWork W2034779847 @default.
- W4361866475 hasRelatedWork W2141330728 @default.
- W4361866475 hasRelatedWork W2188294308 @default.
- W4361866475 hasRelatedWork W2476770332 @default.
- W4361866475 hasRelatedWork W2793303916 @default.
- W4361866475 hasRelatedWork W3209390153 @default.
- W4361866475 hasRelatedWork W4249816251 @default.
- W4361866475 hasRelatedWork W4375865726 @default.
- W4361866475 hasRelatedWork W4384922587 @default.
- W4361866475 hasRelatedWork W573847062 @default.
- W4361866475 hasVolume "26" @default.
- W4361866475 isParatext "false" @default.
- W4361866475 isRetracted "false" @default.
- W4361866475 workType "article" @default.