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• W4361886475 abstract "<p>Figure S1: The PI3K inhibitor buparlisib inhibits AKT phosphorylation and cell growth and induces cell cycle arrest and apoptosis in BRAF-mutant metastatic melanoma cell lines Figure S2: The PI3K inhibitor buparlisib inhibits AKT phosphorylation and cell growth and induces cell cycle arrest and apoptosis in NRAS-mutant metastatic melanoma cell lines Figure S3: Investigating the effects of buparlisib when combined with a MEK or BRAF inhibitor Figure S4: The PI3K inhibitor buparlisib inhibits cell growth in short-term brain melanoma cell lines Figure S5: Fibroblasts are resistant to the PI3K inhibitor buparlisib Figure S6: Buparlisib inhibits exponential growth pattern of brain metastasis in nude mice Figure S7: Histological sections of the brain melanoma tumors provide evidence of hemorrhages, necrosis and tumor regression Figure S8: Buparlisib downregulates pAKT and inhibits proliferation but does not induce apoptosis in brain metastases of nude mice Figure S9: Buparlisib downregulates PLEKHA5 in brain metastases of nude mice</p>" @default.
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• W4361886475 date "2023-03-31" @default.
• W4361886475 modified "2023-09-26" @default.
• W4361886475 title "Supplementary Figures 1_9 from PI3K Pathway Inhibition Achieves Potent Antitumor Activity in Melanoma Brain Metastases <i>In Vitro</i> and <i>In Vivo</i>" @default.
• W4361886475 doi "https://doi.org/10.1158/1078-0432.22466615" @default.
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