FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4361886813> ?p ?o ?g. }

• W4361886813 abstract "<p>Supplementary Table S1. Summary of clinical studies included in the E-R analyses Supplementary Table S2. Model-estimated HR of death (relative to median Cavg1 at 3 mg/kg: 26.9 µg/mL) Supplementary Figure S1. Kaplan-Meier plot of OS in NSCLC by tertile of Cavg1 at (A) 3 mg/kg and (B) 10 mg/kg. Both squamous and non-squamous data were pooled for the Kaplan-Meier analysis. Within-dose E-R relationships were observed for both the (A) 3 mg/kg dose and (B) the 10 mg/kg dose, indicating that factors other than exposure impacted OS. Abbreviations: NSCLC: non-small cell lung cancer; OS: overall survival. Supplementary Figure S2. Kaplan-Meier plot of OS in squamous NSCLC by Cavg1 tertile at a given tertile of baseline clearance; (A) first tertile of baseline clearance and tertile of Cavg1, (B) second tertile of baseline clearance and tertile of Cavg1, and (C) third tertile of baseline clearance and tertile of Cavg1. Exposure was not associated with OS in squamous NSCLC after accounting for the clearance effect, as patients with a higher exposure (red line) appeared to have a reduced or similar clearance effect in comparison with patients with lower exposure (green line). Abbreviations: BCL, baseline clearance; NSCLC: non-small cell lung cancer; T, tertile. Supplementary Figure S3. Kaplan-Meier plot of OS in non-squamous NSCLC by Cavg1 tertile at a given tertile of baseline clearance; (A) first tertile of baseline clearance and tertile of Cavg1, (B) second tertile of baseline clearance and tertile of Cavg1, and (C) third tertile of baseline clearance and tertile of Cavg1. Exposure was not associated with OS in non-squamous NSCLC after accounting for the clearance effect, as patients with higher exposure (blue line) appeared to have a reduced clearance effect in comparison with patients with lower exposure (red line). Abbreviations: Cavg1, model-predicted time-averaged steady-state concentration; BCL, baseline clearance; NSCLC: non-small cell lung cancer; OS, overall survival; T, tertile. Supplementary Figure S4. Kaplan-Meier plot of (A) any-cause grade {greater than or equal to}3 AEs by dose and (B) treatment-related grade {greater than or equal to}3 AEs by dose (B). There was no apparent relationship between dose level and these safety endpoints. Abbreviations: AEs, adverse events.</p>" @default.
• W4361886813 created "2023-04-05" @default.
• W4361886813 creator A5001591660 @default.
• W4361886813 creator A5011152885 @default.
• W4361886813 creator A5019082081 @default.
• W4361886813 creator A5039084645 @default.
• W4361886813 creator A5042806250 @default.
• W4361886813 creator A5060086562 @default.
• W4361886813 creator A5068293021 @default.
• W4361886813 creator A5075574557 @default.
• W4361886813 creator A5084625129 @default.
• W4361886813 date "2023-03-31" @default.
• W4361886813 modified "2023-09-24" @default.
• W4361886813 title "Supplementary tables and figures from Nivolumab Exposure–Response Analyses of Efficacy and Safety in Previously Treated Squamous or Nonsquamous Non–Small Cell Lung Cancer" @default.
• W4361886813 doi "https://doi.org/10.1158/1078-0432.22468856" @default.
• W4361886813 hasPublicationYear "2023" @default.
• W4361886813 type Work @default.
• W4361886813 citedByCount "0" @default.
• W4361886813 crossrefType "posted-content" @default.
• W4361886813 hasAuthorship W4361886813A5001591660 @default.
• W4361886813 hasAuthorship W4361886813A5011152885 @default.
• W4361886813 hasAuthorship W4361886813A5019082081 @default.
• W4361886813 hasAuthorship W4361886813A5039084645 @default.
• W4361886813 hasAuthorship W4361886813A5042806250 @default.
• W4361886813 hasAuthorship W4361886813A5060086562 @default.
• W4361886813 hasAuthorship W4361886813A5068293021 @default.
• W4361886813 hasAuthorship W4361886813A5075574557 @default.
• W4361886813 hasAuthorship W4361886813A5084625129 @default.
• W4361886813 hasBestOaLocation W43618868131 @default.
• W4361886813 hasConcept C121608353 @default.
• W4361886813 hasConcept C126322002 @default.
• W4361886813 hasConcept C143998085 @default.
• W4361886813 hasConcept C2776256026 @default.
• W4361886813 hasConcept C2777701055 @default.
• W4361886813 hasConcept C2780030458 @default.
• W4361886813 hasConcept C71924100 @default.
• W4361886813 hasConceptScore W4361886813C121608353 @default.
• W4361886813 hasConceptScore W4361886813C126322002 @default.
• W4361886813 hasConceptScore W4361886813C143998085 @default.
• W4361886813 hasConceptScore W4361886813C2776256026 @default.
• W4361886813 hasConceptScore W4361886813C2777701055 @default.
• W4361886813 hasConceptScore W4361886813C2780030458 @default.
• W4361886813 hasConceptScore W4361886813C71924100 @default.
• W4361886813 hasLocation W43618868131 @default.
• W4361886813 hasLocation W43618868132 @default.
• W4361886813 hasLocation W43618868133 @default.
• W4361886813 hasOpenAccess W4361886813 @default.
• W4361886813 hasPrimaryLocation W43618868131 @default.
• W4361886813 hasRelatedWork W2390152934 @default.
• W4361886813 hasRelatedWork W2544577077 @default.
• W4361886813 hasRelatedWork W2800538231 @default.
• W4361886813 hasRelatedWork W2883883465 @default.
• W4361886813 hasRelatedWork W2898071776 @default.
• W4361886813 hasRelatedWork W2904759734 @default.
• W4361886813 hasRelatedWork W3029010559 @default.
• W4361886813 hasRelatedWork W3097428643 @default.
• W4361886813 hasRelatedWork W3108448433 @default.
• W4361886813 hasRelatedWork W3215044659 @default.
• W4361886813 isParatext "false" @default.
• W4361886813 isRetracted "false" @default.
• W4361886813 workType "article" @default.