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- W4361920142 abstract "<p>Figure S6: Effect of single and dual blockade (DB) on apoptosis in resistant and parental cell lines. (A) Percentage of cells undergoing apoptosis and necrosis measured by flow cytometry: paired t-test statistics calculated for DB versus no treatment. (NT) (B) Representative confocal microscopy of cleaved caspase-3 (red), after 24 hours of treatment. Blue = DAPI (nuclei). (C) Cleaved caspase-3 immunofluorescence, mean intensity averaged from 4 experiments, with t-test statistics *P<0.05; **P<0.001; ***P<0.0001. (D) Relative migration rate, expressed as increasing percentage cell density across a monolayer wound over 44 hours, mean values from 3 experiments {plus minus} SEM. Treatments are control (black solid), erlotinib 10 µM (E10- black dotted), NVP-AEW541 1 µM (A1- black dashed), NVP-BYL719 5 µM (B5- grey solid), E10A1 (E10+ A1- grey dotted), and E10B5 (E10+ B5- grey dashed). Proliferation was inhibited by 10 µg/ml mitomycin.</p>" @default.
- W4361920142 created "2023-04-05" @default.
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- W4361920142 date "2023-03-31" @default.
- W4361920142 modified "2023-09-23" @default.
- W4361920142 title "Supplementary Figure S6 from Cotargeting of Epidermal Growth Factor Receptor and PI3K Overcomes PI3K–Akt Oncogenic Dependence in Pancreatic Ductal Adenocarcinoma" @default.
- W4361920142 doi "https://doi.org/10.1158/1078-0432.22461140.v1" @default.
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