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• W4361935461 abstract "<p>Contains Supplementary materials and methods, Supplementary Figures S1-S9, Table S2, Table S4, Supplemental References Figure S1, related to Figure 1. Cell surface marker screening of A375P cells treated with vehicle (DMSO) or PLX. Figure S2, related to Figure 1. CD36 is a biomarker of the early stage of MAPK inhibition in melanoma. Figure S3, related to Figure 1. MAPK inhibition induces and maintains the CD36+ population in melanoma cells Figure S4, related to Figure 2. MAPKi induce the expression of genes involved in lipid catabolism in BRAFV600E melanomas. Figure S5, related to Figure 3. MAPK inhibition decreased the glycolytic flux in BRAF-mutated melanoma cells. Figure S6, related to Figure 4. Phenotypic and metabolic characterization of CD36 WT, CD36 KO, CD36+ and CD36- A375P cells. Figure S7, related to Figure 5. PPARα does not regulate CD36 expression. Figure S8, related to Figure 6. Role of glycolysis and FAO inhibitors in proliferation and resistance to MAPKi Figure S9, related to Figure 6. Effects of MAPK, glycolysis and FAO inhibition on mouse and tumor weight. Table S2, related to Figure 1, Figure 3, Figure 6, Figure S3 and Figure S6. Primer list. Table S4, related to Figure 1 and Figure S2. Cell lines, their mutational status and their responsiveness to MAPK inhibitors.</p>" @default.
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• W4361935461 date "2023-03-31" @default.
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• W4361935461 title "Supplementary Data from A Fatty Acid Oxidation-dependent Metabolic Shift Regulates the Adaptation of <i>BRAF</i>-mutated Melanoma to MAPK Inhibitors" @default.
• W4361935461 doi "https://doi.org/10.1158/1078-0432.22471962.v1" @default.
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