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- W4361942416 abstract "<div>Abstract<p><b>Background:</b> Blood leukocytes from patients with solid tumors exhibit complex and distinct cancer-associated patterns of DNA methylation. However, the biologic mechanisms underlying these patterns remain poorly understood. Because epigenetic biomarkers offer significant clinical potential for cancer detection, we sought to address a mechanistic gap in recently published works, hypothesizing that blood-based epigenetic variation may be due to shifts in leukocyte populations.</p><p><b>Methods:</b> We identified differentially methylated regions (DMR) among leukocyte subtypes using epigenome-wide DNA methylation profiling of purified peripheral blood leukocyte subtypes from healthy donors. These leukocyte-tagging DMRs were then evaluated using epigenome-wide blood methylation data from three independent case-control studies of different cancers.</p><p><b>Results:</b> A substantial proportion of the top 50 leukocyte DMRs were significantly differentially methylated among head and neck squamous cell carcinoma (HNSCC) cases and ovarian cancer cases compared with cancer-free controls (48 and 47 of 50, respectively). Methylation classes derived from leukocyte DMRs were significantly associated cancer case status (<i>P</i> < 0.001, <i>P</i> < 0.03, and <i>P</i> < 0.001) for all three cancer types: HNSCC, bladder cancer, and ovarian cancer, respectively and predicted cancer status with a high degree of accuracy (area under the curve [AUC] = 0.82, 0.83, and 0.67).</p><p><b>Conclusions:</b> These results suggest that shifts in leukocyte subpopulations may account for a considerable proportion of variability in peripheral blood DNA methylation patterns of solid tumors.</p><p><b>Impact:</b> This illustrates the potential use of DNA methylation profiles for identifying shifts in leukocyte populations representative of disease, and that such profiles may represent powerful new diagnostic tools, applicable to a range of solid tumors. <i>Cancer Epidemiol Biomarkers Prev; 21(8); 1293–302. ©2012 AACR</i>.</p></div>" @default.
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- W4361942416 date "2023-03-31" @default.
- W4361942416 modified "2023-09-25" @default.
- W4361942416 title "Data from Peripheral Blood Immune Cell Methylation Profiles Are Associated with Nonhematopoietic Cancers" @default.
- W4361942416 doi "https://doi.org/10.1158/1055-9965.c.6515331" @default.
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