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- W4361942564 abstract "<div>Abstract<p><b>Background:</b> Mitosis is a highly regulated process that serves to ensure the fidelity of cell division. The disruption of mitotic regulators leading to aneuploidy and polyploidy is commonly observed in cancer cells. Single nucleotide polymorphisms (SNP) in regulators of mitosis may promote chromosome missegregation and influence pancreatic cancer and/or survival.</p><p><b>Methods:</b> Thirty-four SNPs, previously associated with breast cancer risk, from 33 genes involved in the regulation of mitosis, were investigated for associations with pancreatic cancer risk in 1,143 Caucasian patients with pancreatic adenocarcinoma and 1,097 unaffected controls from the Mayo Clinic. Associations with survival from pancreatic cancer were also assessed using 1,030 pancreatic cancer cases with known outcome.</p><p><b>Results:</b> Two SNPs in the <i>APC</i> (rs2431238) and <i>NIN</i> (rs10145182) loci, of 34 examined, were significantly associated with pancreatic cancer risk (<i>P</i> = 0.035 and <i>P</i> = 0.038, respectively). Further analyses of individuals categorized by smoking and body mass index identified several SNPs displaying significant associations (<i>P</i> < 0.05) with pancreatic cancer risk, including <i>APC</i> rs2431238 in individuals with high body mass index (≥30; <i>P</i> = 0.031) and <i>NIN</i> rs10145182 in ever smokers (<i>P</i> = 0.01). In addition, survival analyses detected significant associations between SNPs in <i>EIF3S10</i> and overall survival (<i>P</i> = 0.009), SNPs from five genes and survival in resected cancer cases (<i>P</i> < 0.05), and SNPs from two other genes (<i>P</i> < 0.05) and survival of locally advanced cancer cases.</p><p><b>Conclusion:</b> Common variation in genes encoding regulators of mitosis may independently influence pancreatic cancer susceptibility and survival. Cancer Epidemiol Biomarkers Prev; 19(1); 251–7</p></div>" @default.
- W4361942564 created "2023-04-05" @default.
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- W4361942564 date "2023-03-31" @default.
- W4361942564 modified "2023-09-26" @default.
- W4361942564 title "Data from Association of Mitotic Regulation Pathway Polymorphisms with Pancreatic Cancer Risk and Outcome" @default.
- W4361942564 doi "https://doi.org/10.1158/1055-9965.c.6516313" @default.
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