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• W4361942912 abstract "<div>Abstract<p><b>Purpose:</b> Severe acute radiation dermatitis is observed in approximately 5% to 10% of patients who receive whole-breast radiotherapy. Several factors, including treatment-related and patient-oriented factors, are involved in susceptibility to severe dermatitis. Genetic factors are also thought to be related to a patient's susceptibility to severe dermatitis. To elucidate genetic polymorphisms associated with a susceptibility to radiation-induced dermatitis, a large-scale single-nucleotide polymorphism (SNP) analysis using DNA samples from 156 patients with breast cancer was conducted.</p><p><b>Experimental Design:</b> Patients were selected from more than 3,000 female patients with early breast cancer who received radiotherapy after undergoing breast-conserving surgery. The dermatitis group was defined as patients who developed dermatitis at a National Cancer Institute Common Toxicity Criteria grade of ≥2. For the SNP analysis, DNA samples from each patient were subjected to the genotyping of 3,144 SNPs covering 494 genes.</p><p><b>Results:</b> SNPs that mapped to two genes, <i>ABCA1</i> and <i>IL12RB2</i>, were associated with radiation-induced dermatitis. In the <i>ABCA1</i> gene, one of these SNPs was a nonsynonymous coding SNP causing R219K (<i>P</i> = 0.0065). As for the <i>IL12RB2</i> gene, the strongest association was observed at SNP-K (rs3790568; <i>P</i> = 0.0013). Using polymorphisms of both genes, the probability of severe dermatitis was estimated for each combination of genotypes. These analyses showed that individuals carrying a combination of genotypes accounting for 14.7% of the Japanese population have the highest probability of developing radiation-induced dermatitis.</p><p><b>Conclusion:</b> Our results shed light on the mechanisms responsible for radiation-induced dermatitis. These results may also contribute to the individualization of radiotherapy.</p></div>" @default.
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• W4361942912 date "2023-03-31" @default.
• W4361942912 modified "2023-10-16" @default.
• W4361942912 title "Data from <i>IL12RB2</i> and <i>ABCA1</i> Genes Are Associated with Susceptibility to Radiation Dermatitis" @default.
• W4361942912 doi "https://doi.org/10.1158/1078-0432.c.6516996" @default.
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