Matches in SemOpenAlex for { <https://semopenalex.org/work/W4361943160> ?p ?o ?g. }
Showing items 1 to 60 of
60
with 100 items per page.
- W4361943160 abstract "<div>Abstract<p><i>Purpose:</i> Breast cancers can display distinct clinical characteristics in different ethnic populations. Previous studies involving European and United States patients have shown that breast tumors can be divided by their gene expression profiles into distinct “molecular subtypes.” In this report, we surveyed a series of invasive and preinvasive breast tumors from Asian-Chinese patients to investigate whether similar subtypes could also be observed in this ethnic group.</p><p><i>Experimental Design and Results:</i> An analysis of expression profiles generated from 11 nonmalignant breast tissues, 17 ductal carcinomas <i>in situ</i> (DCIS) and 98 invasive carcinomas identified three broad molecular subtypes of breast [estrogen receptor (ER)+, ERBB2+ and ER−] in the Asian-Chinese population. These subtypes were highly similar to the “Luminal,” “ERBB2+,” and “Basal” molecular subtypes defined in previous studies, and the subtype-specific expression signatures were also observed in preinvasive DCIS tumors. By comparing the expression profiles of nonmalignant DCIS and invasive breast cancers for two subtypes (ER+ and ERBB2+), we identified several genes that were regulated in both a common and subtype-specific manner during the normal/DCIS and DCIS/invasive carcinoma transitions. Several of these genes were validated by comparison with another recently published similar, but not identical, study.</p><p><i>Conclusions:</i> Our results suggest that molecularly similar subtypes of breast cancer are indeed broadly conserved between Asian and Caucasian patients, and that these subtypes are already present at the preinvasive stage of carcinogenesis. To our knowledge, this study is among the first to directly compare the expression profiles of breast tumors across two different ethnic populations.</p></div>" @default.
- W4361943160 created "2023-04-05" @default.
- W4361943160 creator A5003742732 @default.
- W4361943160 creator A5024845834 @default.
- W4361943160 creator A5058743657 @default.
- W4361943160 creator A5074190354 @default.
- W4361943160 date "2023-03-31" @default.
- W4361943160 modified "2023-09-27" @default.
- W4361943160 title "Data from Conservation of Breast Cancer Molecular Subtypes and Transcriptional Patterns of Tumor Progression Across Distinct Ethnic Populations" @default.
- W4361943160 doi "https://doi.org/10.1158/1078-0432.c.6517560" @default.
- W4361943160 hasPublicationYear "2023" @default.
- W4361943160 type Work @default.
- W4361943160 citedByCount "0" @default.
- W4361943160 crossrefType "posted-content" @default.
- W4361943160 hasAuthorship W4361943160A5003742732 @default.
- W4361943160 hasAuthorship W4361943160A5024845834 @default.
- W4361943160 hasAuthorship W4361943160A5058743657 @default.
- W4361943160 hasAuthorship W4361943160A5074190354 @default.
- W4361943160 hasBestOaLocation W43619431602 @default.
- W4361943160 hasConcept C121608353 @default.
- W4361943160 hasConcept C126322002 @default.
- W4361943160 hasConcept C142724271 @default.
- W4361943160 hasConcept C143998085 @default.
- W4361943160 hasConcept C2780862961 @default.
- W4361943160 hasConcept C2908647359 @default.
- W4361943160 hasConcept C502942594 @default.
- W4361943160 hasConcept C530470458 @default.
- W4361943160 hasConcept C71924100 @default.
- W4361943160 hasConcept C84606932 @default.
- W4361943160 hasConcept C86803240 @default.
- W4361943160 hasConcept C99454951 @default.
- W4361943160 hasConceptScore W4361943160C121608353 @default.
- W4361943160 hasConceptScore W4361943160C126322002 @default.
- W4361943160 hasConceptScore W4361943160C142724271 @default.
- W4361943160 hasConceptScore W4361943160C143998085 @default.
- W4361943160 hasConceptScore W4361943160C2780862961 @default.
- W4361943160 hasConceptScore W4361943160C2908647359 @default.
- W4361943160 hasConceptScore W4361943160C502942594 @default.
- W4361943160 hasConceptScore W4361943160C530470458 @default.
- W4361943160 hasConceptScore W4361943160C71924100 @default.
- W4361943160 hasConceptScore W4361943160C84606932 @default.
- W4361943160 hasConceptScore W4361943160C86803240 @default.
- W4361943160 hasConceptScore W4361943160C99454951 @default.
- W4361943160 hasLocation W43619431601 @default.
- W4361943160 hasLocation W43619431602 @default.
- W4361943160 hasOpenAccess W4361943160 @default.
- W4361943160 hasPrimaryLocation W43619431601 @default.
- W4361943160 hasRelatedWork W2046664158 @default.
- W4361943160 hasRelatedWork W2085880972 @default.
- W4361943160 hasRelatedWork W2224319365 @default.
- W4361943160 hasRelatedWork W2348152691 @default.
- W4361943160 hasRelatedWork W2357456301 @default.
- W4361943160 hasRelatedWork W2369039771 @default.
- W4361943160 hasRelatedWork W2548165902 @default.
- W4361943160 hasRelatedWork W2953241133 @default.
- W4361943160 hasRelatedWork W317834158 @default.
- W4361943160 hasRelatedWork W2555822460 @default.
- W4361943160 isParatext "false" @default.
- W4361943160 isRetracted "false" @default.
- W4361943160 workType "article" @default.