FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4361943669> ?p ?o ?g. }

• W4361943669 abstract "<div>Abstract<p><b>Purpose:</b> We studied the expression levels of cyclins B1, D1, and E1 and the implications of cyclin overexpression for patient outcomes in distinct breast cancer subtypes defined by clinical variables and transcriptional profiling.</p><p><b>Experimental Design:</b> The expression levels of cyclins B1, D1, and E1 were quantified in 779 breast tumors and 53 cell lines using reverse phase protein arrays and/or transcriptional profiling.</p><p><b>Results:</b> Whereas cyclin E1 overexpression was a specific marker of triple-negative and basal-like tumors, cyclin B1 overexpression occurred in poor prognosis hormone receptor–positive, luminal B and basal-like breast cancers. Cyclin D1 overexpression occurred in luminal and normal-like cancers. Breast cancer subgroups defined by integrated expression of cyclins B1, D1, and E1 correlated significantly (<i>P</i> < 0.000001) with tumor subtypes defined by transcriptional profiling and clinical criteria. Across three hormone receptor–positive data sets, cyclin B1 was the dominant cyclin associated with poor prognosis in univariate and multivariate analyses. Although <i>CCNE1</i> was present in significantly higher copy numbers in basal-like versus other subtypes (ANOVA <i>P</i> < 0.001), <i>CCNB1</i> gene copy number did not show gain in breast cancer. Instead, cyclin B1 expression was increased in tumors with co-occurrence of <i>TP53</i> mutations and <i>MYC</i> amplification, a combination that seems to characterize basal-like and luminal B tumors. <i>CCNB1</i> gene expression was significantly correlated with <i>PLK, CENPE</i>, and <i>AURKB</i> gene expression.</p><p><b>Conclusion:</b> Cyclins B1, D1, and E1 have distinct expressions in different breast cancer subtypes. Novel <i>PLK, CENPE</i>, and <i>AURKB</i> inhibitors should be assessed for therapeutic utility in poor prognosis cyclin B1–overexpressing breast cancers.</p></div>" @default.
• W4361943669 created "2023-04-05" @default.
• W4361943669 creator A5002175298 @default.
• W4361943669 creator A5004102701 @default.
• W4361943669 creator A5004954310 @default.
• W4361943669 creator A5005221518 @default.
• W4361943669 creator A5012792113 @default.
• W4361943669 creator A5018264282 @default.
• W4361943669 creator A5026179323 @default.
• W4361943669 creator A5028899187 @default.
• W4361943669 creator A5041098535 @default.
• W4361943669 creator A5042281888 @default.
• W4361943669 creator A5042960706 @default.
• W4361943669 creator A5052676245 @default.
• W4361943669 creator A5063966287 @default.
• W4361943669 creator A5065620415 @default.
• W4361943669 creator A5066252101 @default.
• W4361943669 creator A5073129301 @default.
• W4361943669 creator A5080832682 @default.
• W4361943669 creator A5083875677 @default.
• W4361943669 creator A5086242617 @default.
• W4361943669 date "2023-03-31" @default.
• W4361943669 modified "2023-10-16" @default.
• W4361943669 title "Data from Integrative Analysis of Cyclin Protein Levels Identifies Cyclin B1 as a Classifier and Predictor of Outcomes in Breast Cancer" @default.
• W4361943669 doi "https://doi.org/10.1158/1078-0432.c.6517852" @default.
• W4361943669 hasPublicationYear "2023" @default.
• W4361943669 type Work @default.
• W4361943669 citedByCount "0" @default.
• W4361943669 crossrefType "posted-content" @default.
• W4361943669 hasAuthorship W4361943669A5002175298 @default.
• W4361943669 hasAuthorship W4361943669A5004102701 @default.
• W4361943669 hasAuthorship W4361943669A5004954310 @default.
• W4361943669 hasAuthorship W4361943669A5005221518 @default.
• W4361943669 hasAuthorship W4361943669A5012792113 @default.
• W4361943669 hasAuthorship W4361943669A5018264282 @default.
• W4361943669 hasAuthorship W4361943669A5026179323 @default.
• W4361943669 hasAuthorship W4361943669A5028899187 @default.
• W4361943669 hasAuthorship W4361943669A5041098535 @default.
• W4361943669 hasAuthorship W4361943669A5042281888 @default.
• W4361943669 hasAuthorship W4361943669A5042960706 @default.
• W4361943669 hasAuthorship W4361943669A5052676245 @default.
• W4361943669 hasAuthorship W4361943669A5063966287 @default.
• W4361943669 hasAuthorship W4361943669A5065620415 @default.
• W4361943669 hasAuthorship W4361943669A5066252101 @default.
• W4361943669 hasAuthorship W4361943669A5073129301 @default.
• W4361943669 hasAuthorship W4361943669A5080832682 @default.
• W4361943669 hasAuthorship W4361943669A5083875677 @default.
• W4361943669 hasAuthorship W4361943669A5086242617 @default.
• W4361943669 hasBestOaLocation W43619436692 @default.
• W4361943669 hasConcept C11882975 @default.
• W4361943669 hasConcept C120089663 @default.
• W4361943669 hasConcept C120504264 @default.
• W4361943669 hasConcept C121608353 @default.
• W4361943669 hasConcept C126322002 @default.
• W4361943669 hasConcept C16438837 @default.
• W4361943669 hasConcept C199835354 @default.
• W4361943669 hasConcept C2778437423 @default.
• W4361943669 hasConcept C2780360765 @default.
• W4361943669 hasConcept C28179978 @default.
• W4361943669 hasConcept C29537977 @default.
• W4361943669 hasConcept C502942594 @default.
• W4361943669 hasConcept C530470458 @default.
• W4361943669 hasConcept C71924100 @default.
• W4361943669 hasConcept C86803240 @default.
• W4361943669 hasConcept C94561458 @default.
• W4361943669 hasConcept C9743823 @default.
• W4361943669 hasConceptScore W4361943669C11882975 @default.
• W4361943669 hasConceptScore W4361943669C120089663 @default.
• W4361943669 hasConceptScore W4361943669C120504264 @default.
• W4361943669 hasConceptScore W4361943669C121608353 @default.
• W4361943669 hasConceptScore W4361943669C126322002 @default.
• W4361943669 hasConceptScore W4361943669C16438837 @default.
• W4361943669 hasConceptScore W4361943669C199835354 @default.
• W4361943669 hasConceptScore W4361943669C2778437423 @default.
• W4361943669 hasConceptScore W4361943669C2780360765 @default.
• W4361943669 hasConceptScore W4361943669C28179978 @default.
• W4361943669 hasConceptScore W4361943669C29537977 @default.
• W4361943669 hasConceptScore W4361943669C502942594 @default.
• W4361943669 hasConceptScore W4361943669C530470458 @default.
• W4361943669 hasConceptScore W4361943669C71924100 @default.
• W4361943669 hasConceptScore W4361943669C86803240 @default.
• W4361943669 hasConceptScore W4361943669C94561458 @default.
• W4361943669 hasConceptScore W4361943669C9743823 @default.
• W4361943669 hasLocation W43619436691 @default.
• W4361943669 hasLocation W43619436692 @default.
• W4361943669 hasOpenAccess W4361943669 @default.
• W4361943669 hasPrimaryLocation W43619436691 @default.
• W4361943669 hasRelatedWork W1958045966 @default.
• W4361943669 hasRelatedWork W2058365474 @default.
• W4361943669 hasRelatedWork W2084566512 @default.
• W4361943669 hasRelatedWork W2090071522 @default.
• W4361943669 hasRelatedWork W2130943637 @default.
• W4361943669 hasRelatedWork W2330642742 @default.
• W4361943669 hasRelatedWork W2376313276 @default.
• W4361943669 hasRelatedWork W2789271127 @default.
• W4361943669 hasRelatedWork W2934750731 @default.
• W4361943669 hasRelatedWork W2109907800 @default.
• W4361943669 isParatext "false" @default.
• W4361943669 isRetracted "false" @default.
• W4361943669 workType "article" @default.