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- W4361943800 abstract "<div>Abstract<p><b>Purpose:</b> Multiple endocrine neoplasia type 1 (MEN1) is defined clinically by the combined occurrence of multiple tumors, typically of the parathyroid glands, pancreatic islet cells, and anterior pituitary gland. A mouse model with a heterozygous deletion of the <i>Men1</i> gene recapitulates the tumorigenesis of MEN1. We wished to determine the role of vascular endothelial growth factor (VEGF)-A in the vascularization and growth of MEN1-associated tumors, with an emphasis on pituitary adenomas.</p><p><b>Experimental Design:</b> To investigate whether tumor growth in <i>Men1</i><sup>+/−</sup> mice is mediated by VEGF-A dependent angiogenesis, we carried out a monotherapy with the anti–VEGF-A monoclonal antibody (mAb) G6-31. We evaluated tumor growth by magnetic resonance imaging and assessed vascular density in tissue sections. We also measured hormone levels in the serum.</p><p><b>Results:</b> During the treatment with mAb G6-31, a significant inhibition of the pituitary adenoma growth was observed, leading to an increased mean tumor doubling-free survival compared with mice treated with a control antibody. Similarly, the growth of s.c. pituitary adenoma transplants was effectively inhibited by administration of anti–VEGF-A mAb. Serum prolactin was lowered by mAb G6-31 treatment but not by control antibody, potentially providing a new therapeutic approach for treating the hormonal excess in MEN1 patients. Additionally, the vascular density in pancreatic islet tumors was significantly reduced by the treatment.</p><p><b>Conclusions:</b> These results suggest that VEGF-A blockade may represent a nonsurgical treatment for benign tumors of the endocrine system.</p></div>" @default.
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- W4361943800 date "2023-03-31" @default.
- W4361943800 modified "2023-10-14" @default.
- W4361943800 title "Data from Blocking Vascular Endothelial Growth Factor-A Inhibits the Growth of Pituitary Adenomas and Lowers Serum Prolactin Level in a Mouse Model of Multiple Endocrine Neoplasia Type 1" @default.
- W4361943800 doi "https://doi.org/10.1158/1078-0432.c.6518419" @default.
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