FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4361944015> ?p ?o ?g. }

• W4361944015 abstract "<div>Abstract<p><b>Purpose:</b> Racotumomab-alum is an anti-idiotype vaccine targeting the NeuGcGM3 tumor-associated ganglioside. This clinical trial was conducted to provide a preliminary estimate of efficacy and safety of racotumomab as switch maintenance for patients with advanced non–small cell lung cancer (NSCLC).</p><p><b>Experimental design:</b> Patients with stage IIIb/IV NSCLC who have at least stable disease after first-line chemotherapy were randomized 1:1 to racotumomab-alum (5 immunizations every 2 weeks and re-immunizations every 4 weeks) or placebo. Treatment was administered beyond progressive disease, until severe performance status worsening or toxicity. At progression, only five patients per group received further anticancer therapy. The primary endpoint was overall survival (OS).</p><p><b>Results:</b> One-hundred and seventy-six patients were randomized to racotumomab-alum (<i>n</i> = 87) and placebo (<i>n</i> = 89). Median OS was 8.23 and 6.80 months, respectively [HR, 0.63; 95% confidence interval (CI), 0.46–0.87; <i>P</i> = 0.004]. Median progression-free survival (PFS) in vaccinated patients was 5.33 versus 3.90 months for placebo (HR, 0.73; 95% CI 0.53–0.99; <i>P</i> = 0.039). The most common adverse events in the racotumomab-alum arm were burning and pain at the injection site, bone pain, and asthenia. A high antibody response of IgM and IgG isotype against the NeuGcGM3 ganglioside was obtained. Hyperimmune sera were able to specifically recognize and kill the NeuGcGM3-expressing L1210 cell line. Patients who developed anti-NeuGcGM3 antibodies capable to bind and kill ≥30% L1210 cells showed longer median survival times.</p><p><b>Conclusions:</b> Switch maintenance with racotumomab-alum is an effective and a well-tolerated treatment option for patients with advanced NSCLC. <i>Clin Cancer Res; 20(14); 3660–71. ©2014 AACR</i>.</p></div>" @default.
• W4361944015 created "2023-04-05" @default.
• W4361944015 creator A5003434643 @default.
• W4361944015 creator A5006318317 @default.
• W4361944015 creator A5006803964 @default.
• W4361944015 creator A5007907994 @default.
• W4361944015 creator A5028090850 @default.
• W4361944015 creator A5030922963 @default.
• W4361944015 creator A5032549592 @default.
• W4361944015 creator A5032855565 @default.
• W4361944015 creator A5042963282 @default.
• W4361944015 creator A5043284372 @default.
• W4361944015 creator A5046958363 @default.
• W4361944015 creator A5050286978 @default.
• W4361944015 creator A5055596200 @default.
• W4361944015 creator A5057610184 @default.
• W4361944015 creator A5063671859 @default.
• W4361944015 creator A5065298283 @default.
• W4361944015 creator A5067739096 @default.
• W4361944015 creator A5071245221 @default.
• W4361944015 creator A5074286681 @default.
• W4361944015 creator A5074443410 @default.
• W4361944015 creator A5087539011 @default.
• W4361944015 creator A5090693703 @default.
• W4361944015 creator A5091692308 @default.
• W4361944015 date "2023-03-31" @default.
• W4361944015 modified "2023-10-15" @default.
• W4361944015 title "Data from A Randomized, Multicenter, Placebo-Controlled Clinical Trial of Racotumomab-Alum Vaccine as Switch Maintenance Therapy in Advanced Non–Small Cell Lung Cancer Patients" @default.
• W4361944015 doi "https://doi.org/10.1158/1078-0432.c.6520869" @default.
• W4361944015 hasPublicationYear "2023" @default.
• W4361944015 type Work @default.
• W4361944015 citedByCount "0" @default.
• W4361944015 crossrefType "posted-content" @default.
• W4361944015 hasAuthorship W4361944015A5003434643 @default.
• W4361944015 hasAuthorship W4361944015A5006318317 @default.
• W4361944015 hasAuthorship W4361944015A5006803964 @default.
• W4361944015 hasAuthorship W4361944015A5007907994 @default.
• W4361944015 hasAuthorship W4361944015A5028090850 @default.
• W4361944015 hasAuthorship W4361944015A5030922963 @default.
• W4361944015 hasAuthorship W4361944015A5032549592 @default.
• W4361944015 hasAuthorship W4361944015A5032855565 @default.
• W4361944015 hasAuthorship W4361944015A5042963282 @default.
• W4361944015 hasAuthorship W4361944015A5043284372 @default.
• W4361944015 hasAuthorship W4361944015A5046958363 @default.
• W4361944015 hasAuthorship W4361944015A5050286978 @default.
• W4361944015 hasAuthorship W4361944015A5055596200 @default.
• W4361944015 hasAuthorship W4361944015A5057610184 @default.
• W4361944015 hasAuthorship W4361944015A5063671859 @default.
• W4361944015 hasAuthorship W4361944015A5065298283 @default.
• W4361944015 hasAuthorship W4361944015A5067739096 @default.
• W4361944015 hasAuthorship W4361944015A5071245221 @default.
• W4361944015 hasAuthorship W4361944015A5074286681 @default.
• W4361944015 hasAuthorship W4361944015A5074443410 @default.
• W4361944015 hasAuthorship W4361944015A5087539011 @default.
• W4361944015 hasAuthorship W4361944015A5090693703 @default.
• W4361944015 hasAuthorship W4361944015A5091692308 @default.
• W4361944015 hasBestOaLocation W43619440152 @default.
• W4361944015 hasConcept C126322002 @default.
• W4361944015 hasConcept C141071460 @default.
• W4361944015 hasConcept C142724271 @default.
• W4361944015 hasConcept C168563851 @default.
• W4361944015 hasConcept C191897082 @default.
• W4361944015 hasConcept C192562407 @default.
• W4361944015 hasConcept C197934379 @default.
• W4361944015 hasConcept C203092338 @default.
• W4361944015 hasConcept C204787440 @default.
• W4361944015 hasConcept C27081682 @default.
• W4361944015 hasConcept C2776256026 @default.
• W4361944015 hasConcept C2780924562 @default.
• W4361944015 hasConcept C71924100 @default.
• W4361944015 hasConcept C90924648 @default.
• W4361944015 hasConceptScore W4361944015C126322002 @default.
• W4361944015 hasConceptScore W4361944015C141071460 @default.
• W4361944015 hasConceptScore W4361944015C142724271 @default.
• W4361944015 hasConceptScore W4361944015C168563851 @default.
• W4361944015 hasConceptScore W4361944015C191897082 @default.
• W4361944015 hasConceptScore W4361944015C192562407 @default.
• W4361944015 hasConceptScore W4361944015C197934379 @default.
• W4361944015 hasConceptScore W4361944015C203092338 @default.
• W4361944015 hasConceptScore W4361944015C204787440 @default.
• W4361944015 hasConceptScore W4361944015C27081682 @default.
• W4361944015 hasConceptScore W4361944015C2776256026 @default.
• W4361944015 hasConceptScore W4361944015C2780924562 @default.
• W4361944015 hasConceptScore W4361944015C71924100 @default.
• W4361944015 hasConceptScore W4361944015C90924648 @default.
• W4361944015 hasLocation W43619440151 @default.
• W4361944015 hasLocation W43619440152 @default.
• W4361944015 hasOpenAccess W4361944015 @default.
• W4361944015 hasPrimaryLocation W43619440151 @default.
• W4361944015 hasRelatedWork W2040329707 @default.
• W4361944015 hasRelatedWork W2766008196 @default.
• W4361944015 hasRelatedWork W3007053288 @default.
• W4361944015 hasRelatedWork W3125174675 @default.
• W4361944015 hasRelatedWork W3155195005 @default.
• W4361944015 hasRelatedWork W3172359983 @default.
• W4361944015 hasRelatedWork W3212096909 @default.
• W4361944015 hasRelatedWork W4289444310 @default.
• W4361944015 hasRelatedWork W4306253774 @default.
• W4361944015 hasRelatedWork W4376137143 @default.
• W4361944015 isParatext "false" @default.

• next