Matches in SemOpenAlex for { <https://semopenalex.org/work/W4361944038> ?p ?o ?g. }
Showing items 1 to 60 of
60
with 100 items per page.
- W4361944038 abstract "<div>Abstract<p>Although they have been advocated with an understandable enthusiasm, mitosis-specific agents such as inhibitors of mitotic kinases and kinesin spindle protein have not been successful clinically. These drugs were developed as agents that would build on the success of microtubule-targeting agents while avoiding the neurotoxicity that encumbers drugs such as taxanes and vinca alkaloids. The rationale for using mitosis-specific agents was based on the thesis that the clinical efficacy of microtubule-targeting agents could be ascribed to the induction of mitotic arrest. However, the latter concept, which has long been accepted as dogma, is likely important only in cell culture and rapidly growing preclinical models, and irrelevant in patient tumors, where interference with intracellular trafficking on microtubules is likely the principal mechanism of action. Here we review the preclinical and clinical data for a diverse group of inhibitors that target mitosis and identify the reasons why these highly specific, myelosuppressive compounds have failed to deliver on their promise. <i>Clin Cancer Res; 18(1); 51–63. ©2012 AACR</i>.</p></div>" @default.
- W4361944038 created "2023-04-05" @default.
- W4361944038 creator A5006254176 @default.
- W4361944038 creator A5025708608 @default.
- W4361944038 creator A5047856599 @default.
- W4361944038 date "2023-03-31" @default.
- W4361944038 modified "2023-10-14" @default.
- W4361944038 title "Data from Inhibitors Targeting Mitosis: Tales of How Great Drugs against a Promising Target Were Brought Down by a Flawed Rationale" @default.
- W4361944038 doi "https://doi.org/10.1158/1078-0432.c.6520901" @default.
- W4361944038 hasPublicationYear "2023" @default.
- W4361944038 type Work @default.
- W4361944038 citedByCount "0" @default.
- W4361944038 crossrefType "posted-content" @default.
- W4361944038 hasAuthorship W4361944038A5006254176 @default.
- W4361944038 hasAuthorship W4361944038A5025708608 @default.
- W4361944038 hasAuthorship W4361944038A5047856599 @default.
- W4361944038 hasBestOaLocation W43619440382 @default.
- W4361944038 hasConcept C111472728 @default.
- W4361944038 hasConcept C138885662 @default.
- W4361944038 hasConcept C20418707 @default.
- W4361944038 hasConcept C2777096885 @default.
- W4361944038 hasConcept C2909592991 @default.
- W4361944038 hasConcept C502942594 @default.
- W4361944038 hasConcept C71924100 @default.
- W4361944038 hasConcept C84425145 @default.
- W4361944038 hasConcept C86803240 @default.
- W4361944038 hasConcept C89611455 @default.
- W4361944038 hasConcept C93304396 @default.
- W4361944038 hasConcept C95444343 @default.
- W4361944038 hasConcept C98274493 @default.
- W4361944038 hasConceptScore W4361944038C111472728 @default.
- W4361944038 hasConceptScore W4361944038C138885662 @default.
- W4361944038 hasConceptScore W4361944038C20418707 @default.
- W4361944038 hasConceptScore W4361944038C2777096885 @default.
- W4361944038 hasConceptScore W4361944038C2909592991 @default.
- W4361944038 hasConceptScore W4361944038C502942594 @default.
- W4361944038 hasConceptScore W4361944038C71924100 @default.
- W4361944038 hasConceptScore W4361944038C84425145 @default.
- W4361944038 hasConceptScore W4361944038C86803240 @default.
- W4361944038 hasConceptScore W4361944038C89611455 @default.
- W4361944038 hasConceptScore W4361944038C93304396 @default.
- W4361944038 hasConceptScore W4361944038C95444343 @default.
- W4361944038 hasConceptScore W4361944038C98274493 @default.
- W4361944038 hasLocation W43619440381 @default.
- W4361944038 hasLocation W43619440382 @default.
- W4361944038 hasOpenAccess W4361944038 @default.
- W4361944038 hasPrimaryLocation W43619440381 @default.
- W4361944038 hasRelatedWork W1998766450 @default.
- W4361944038 hasRelatedWork W2040389083 @default.
- W4361944038 hasRelatedWork W2073895941 @default.
- W4361944038 hasRelatedWork W2080344737 @default.
- W4361944038 hasRelatedWork W2626299559 @default.
- W4361944038 hasRelatedWork W2900017207 @default.
- W4361944038 hasRelatedWork W2970017625 @default.
- W4361944038 hasRelatedWork W3087210453 @default.
- W4361944038 hasRelatedWork W4225373697 @default.
- W4361944038 hasRelatedWork W798453310 @default.
- W4361944038 isParatext "false" @default.
- W4361944038 isRetracted "false" @default.
- W4361944038 workType "article" @default.