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- W4361944194 abstract "<div>Abstract<p>STAT1 is activated by IFNs and other cell signals. Following activation, STAT1 is translocated to the nuclei and activates transcription of IFN-stimulated genes. Although the activation of STAT1 by IFNs is classically associated with antiviral defense and tumor-suppressive functions, emerging data indicate that expression of the STAT1 pathway confers cellular resistance to DNA-damaging agents and mediates aggressive tumor growth. Recent advances in the development of Janus-activated kinase/Stat inhibitors and peptide inhibitors specific for individual Stat proteins may provide new insights into the controversial functions of this pathway. <i>Clin Cancer Res; 18(11); 3015–21. ©2012 AACR</i>.</p></div>" @default.
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- W4361944194 date "2023-03-31" @default.
- W4361944194 modified "2023-09-25" @default.
- W4361944194 title "Data from Molecular Pathways: Interferon/Stat1 Pathway: Role in the Tumor Resistance to Genotoxic Stress and Aggressive Growth" @default.
- W4361944194 doi "https://doi.org/10.1158/1078-0432.c.6520797" @default.
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