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- W4361944547 abstract "<div>Abstract<p><b>Purpose:</b> Several single-nucleotide polymorphisms (SNP) in the interleukin-28B (<i>IL-28B</i>) locus have recently been shown to be associated with antiviral treatment efficacy for chronic hepatitis C (CHC). However, such an association with hepatocellular carcinoma (HCC) is unkno3 we investigated the association between the <i>IL-28B</i> genotype and the biology and clinical outcome of patients with HCC receiving curative treatment.</p><p><b>Experimental Design:</b> Genotyping of 183 patients with HCC with CHC who were treated with hepatic resection or radiofrequency ablation (RFA) was carried out, and the results were analyzed to determine the association between the <i>IL-28B</i> genotype (rs8099917) and clinical outcome. Gene expression profiles of 20 patients with HCC and another series of 91 patients with CHC were analyzed using microarray analysis and gene set enrichment analysis. Histologic and immunohistochemical analyses were also conducted.</p><p><b>Results:</b> The TT, TG, and GG proportions of the rs8099917 genotype were 67.8% (124 of 183), 30.6% (56 of 183), and 1.6% (3 of 183), respectively. Multivariate Cox proportional hazard analysis showed that the <i>IL-28B</i> TT genotype was significantly associated with HCC recurrence (<i>P</i> = 0.007; HR, 2.674; 95% confidence interval, 1.16–2.63). Microarray analysis showed high expression levels of IFN-stimulated genes in background liver samples and immune-related genes in tumor tissues of the <i>IL-28B</i> TG/GG genotype. Histologic findings showed that more lymphocytes infiltrated into tumor tissues in the TG/GG genotype.</p><p><b>Conclusions:</b> The <i>IL-28B</i> genotype is associated with HCC recurrence, gene expression, and histologic findings in patients with CHC. <i>Clin Cancer Res; 19(7); 1827–37. ©2013 AACR</i>.</p></div>" @default.
- W4361944547 created "2023-04-05" @default.
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- W4361944547 date "2023-03-31" @default.
- W4361944547 modified "2023-10-14" @default.
- W4361944547 title "Data from Association of <i>Interleukin-28B</i> Genotype and Hepatocellular Carcinoma Recurrence in Patients with Chronic Hepatitis C" @default.
- W4361944547 doi "https://doi.org/10.1158/1078-0432.c.6522818" @default.
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