FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4361944990> ?p ?o ?g. }

• W4361944990 abstract "<div>Abstract<p><b>Purpose:</b> The aim of this study was to identify noninvasive pharmacodynamic biomarkers of FGFR3-targeted therapies in bladder cancer to facilitate the clinical development of experimental agent targeting FGFR3.</p><p><b>Experimental Design:</b> Potential soluble pharmacodynamic biomarkers of FGFR3 were identified using a combination of transcriptional profiling and biochemical analyses in preclinical models. Two matrix metalloproteinases (MMP), MMP-1 and MMP-10, were selected for further studies in human bladder cancer xenograft models treated with a specific anti-FGFR3 monoclonal antibody, R3Mab. Serum and urinary levels of MMP-1 and MMP-10 were determined in healthy donors and patients with bladder cancer. The modulation of MMP-1 and MMP-10 by R3Mab in patients with bladder cancer was further evaluated in a phase I dose-escalation study.</p><p><b>Results:</b> MMP-1 and MMP-10 mRNA and protein were downmodulated by FGFR3 shRNA and R3Mab in bladder cancer cell lines. FGFR3 signaling promoted the expression and secretion of MMP-1 and pro-MMP-10 in a MEK-dependent fashion. In bladder cancer xenograft models, R3Mab substantially blocked tumor progression and reduced the protein levels of human MMP-1 and pro-MMP-10 in tumor tissues as well as in mouse serum. Furthermore, both MMP-1 and pro-MMP-10 were elevated in the urine of patients with advanced bladder cancer. In a phase I dose-escalation trial, R3Mab administration resulted in an acute reduction of urinary MMP-1 and pro-MMP-10 levels in patients with bladder cancer.</p><p><b>Conclusion:</b> These findings reveal a critical role of FGFR3 in regulating MMP-1 and pro-MMP-10 expression and secretion, and identify urinary MMP-1 and pro-MMP-10 as potential pharmacodynamic biomarkers for R3Mab in patients with bladder cancer. <i>Clin Cancer Res; 20(24); 6324–35. ©2014 AACR</i>.</p></div>" @default.
• W4361944990 created "2023-04-05" @default.
• W4361944990 creator A5000291728 @default.
• W4361944990 creator A5007056687 @default.
• W4361944990 creator A5019560977 @default.
• W4361944990 creator A5028133447 @default.
• W4361944990 creator A5054567757 @default.
• W4361944990 creator A5056062093 @default.
• W4361944990 creator A5063601871 @default.
• W4361944990 creator A5064252604 @default.
• W4361944990 creator A5073170085 @default.
• W4361944990 creator A5090977353 @default.
• W4361944990 date "2023-03-31" @default.
• W4361944990 modified "2023-09-28" @default.
• W4361944990 title "Data from MMP-1 and Pro-MMP-10 as Potential Urinary Pharmacodynamic Biomarkers of FGFR3-Targeted Therapy in Patients with Bladder Cancer" @default.
• W4361944990 doi "https://doi.org/10.1158/1078-0432.c.6523554" @default.
• W4361944990 hasPublicationYear "2023" @default.
• W4361944990 type Work @default.
• W4361944990 citedByCount "0" @default.
• W4361944990 crossrefType "posted-content" @default.
• W4361944990 hasAuthorship W4361944990A5000291728 @default.
• W4361944990 hasAuthorship W4361944990A5007056687 @default.
• W4361944990 hasAuthorship W4361944990A5019560977 @default.
• W4361944990 hasAuthorship W4361944990A5028133447 @default.
• W4361944990 hasAuthorship W4361944990A5054567757 @default.
• W4361944990 hasAuthorship W4361944990A5056062093 @default.
• W4361944990 hasAuthorship W4361944990A5063601871 @default.
• W4361944990 hasAuthorship W4361944990A5064252604 @default.
• W4361944990 hasAuthorship W4361944990A5073170085 @default.
• W4361944990 hasAuthorship W4361944990A5090977353 @default.
• W4361944990 hasConcept C109523444 @default.
• W4361944990 hasConcept C111113717 @default.
• W4361944990 hasConcept C112705442 @default.
• W4361944990 hasConcept C121608353 @default.
• W4361944990 hasConcept C126322002 @default.
• W4361944990 hasConcept C2780352672 @default.
• W4361944990 hasConcept C502942594 @default.
• W4361944990 hasConcept C71924100 @default.
• W4361944990 hasConcept C77411442 @default.
• W4361944990 hasConceptScore W4361944990C109523444 @default.
• W4361944990 hasConceptScore W4361944990C111113717 @default.
• W4361944990 hasConceptScore W4361944990C112705442 @default.
• W4361944990 hasConceptScore W4361944990C121608353 @default.
• W4361944990 hasConceptScore W4361944990C126322002 @default.
• W4361944990 hasConceptScore W4361944990C2780352672 @default.
• W4361944990 hasConceptScore W4361944990C502942594 @default.
• W4361944990 hasConceptScore W4361944990C71924100 @default.
• W4361944990 hasConceptScore W4361944990C77411442 @default.
• W4361944990 hasLocation W43619449901 @default.
• W4361944990 hasOpenAccess W4361944990 @default.
• W4361944990 hasPrimaryLocation W43619449901 @default.
• W4361944990 hasRelatedWork W1979321249 @default.
• W4361944990 hasRelatedWork W2011500441 @default.
• W4361944990 hasRelatedWork W2412574627 @default.
• W4361944990 hasRelatedWork W2415761310 @default.
• W4361944990 hasRelatedWork W2474195589 @default.
• W4361944990 hasRelatedWork W2517659937 @default.
• W4361944990 hasRelatedWork W2609459726 @default.
• W4361944990 hasRelatedWork W4235671009 @default.
• W4361944990 hasRelatedWork W4288392727 @default.
• W4361944990 hasRelatedWork W2118673085 @default.
• W4361944990 isParatext "false" @default.
• W4361944990 isRetracted "false" @default.
• W4361944990 workType "article" @default.