FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4361946181> ?p ?o ?g. }

• W4361946181 abstract "<div>Abstract<p><b>Purpose:</b> Pancreatic ductal adenocarcinoma (PDAC) is refractory to available treatments. Delineating critical pathways, responsible for disease aggressiveness and therapeutic resistance, may identify effective therapeutic targets. We aimed to identify key pathways contributing to disease aggressiveness by comparing gene expression profiles of tumors from early-stage PDAC cases with extremely poor survival (≤7 months) and those surviving 2 years or more following surgical resection.</p><p><b>Experimental Design:</b> Gene expression profiling was performed in tumors in a test cohort of PDAC (<i>N</i> = 50), which included short (≤7 months, <i>N</i> = 11) and long surviving (≥2 years, <i>N</i> = 14) patients, using affymetrix GeneChip Human 1.0 ST array. Key genes associated with disease aggressiveness were identified, using Cox regression, Kaplan–Meier, and pathway analyses with validations in independent cohorts for mechanistic and functional analyses.</p><p><b>Results:</b> Gene expression profiling identified 1,820 differentially expressed genes between short and long survival groups with inflammatory gene network ranking first. Lower expression of endothelial nitric oxide synthase traffic inducer (NOSTRIN) was associated with worst survival indicating its potential inhibitory role in disease progression. NOSTRIN overexpression suppressed migration and invasion of pancreatic cancer cells and enhanced sensitivity to chemotherapeutic drug gemcitabine. NOSTRIN inhibited production of nitric oxide (NO) by suppressing the activation of endothelial nitric oxide synthase (eNOS). Furthermore, miR-221, bound to the 3′UTR of NOSTRIN and suppressed its expression, and an increased miR-221 expression associated with poor survival in PDAC.</p><p><b>Conclusions:</b> Our findings showed that NOSTRIN is a potential negative regulator of disease aggressiveness, which may be targeted for designing improved treatment strategy in PDAC. <i>Clin Cancer Res; 22(24); 5992–6001. ©2016 AACR</i>.</p></div>" @default.
• W4361946181 created "2023-04-05" @default.
• W4361946181 creator A5001050976 @default.
• W4361946181 creator A5017329101 @default.
• W4361946181 creator A5023489930 @default.
• W4361946181 creator A5031392514 @default.
• W4361946181 creator A5032764121 @default.
• W4361946181 creator A5041359420 @default.
• W4361946181 creator A5044498630 @default.
• W4361946181 creator A5052087705 @default.
• W4361946181 creator A5056457511 @default.
• W4361946181 creator A5073284312 @default.
• W4361946181 creator A5084852606 @default.
• W4361946181 creator A5087563919 @default.
• W4361946181 creator A5091148741 @default.
• W4361946181 date "2023-03-31" @default.
• W4361946181 modified "2023-09-28" @default.
• W4361946181 title "Data from Endothelial Nitric Oxide Synthase Traffic Inducer (NOSTRIN) is a Negative Regulator of Disease Aggressiveness in Pancreatic Cancer" @default.
• W4361946181 doi "https://doi.org/10.1158/1078-0432.c.6526688" @default.
• W4361946181 hasPublicationYear "2023" @default.
• W4361946181 type Work @default.
• W4361946181 citedByCount "0" @default.
• W4361946181 crossrefType "posted-content" @default.
• W4361946181 hasAuthorship W4361946181A5001050976 @default.
• W4361946181 hasAuthorship W4361946181A5017329101 @default.
• W4361946181 hasAuthorship W4361946181A5023489930 @default.
• W4361946181 hasAuthorship W4361946181A5031392514 @default.
• W4361946181 hasAuthorship W4361946181A5032764121 @default.
• W4361946181 hasAuthorship W4361946181A5041359420 @default.
• W4361946181 hasAuthorship W4361946181A5044498630 @default.
• W4361946181 hasAuthorship W4361946181A5052087705 @default.
• W4361946181 hasAuthorship W4361946181A5056457511 @default.
• W4361946181 hasAuthorship W4361946181A5073284312 @default.
• W4361946181 hasAuthorship W4361946181A5084852606 @default.
• W4361946181 hasAuthorship W4361946181A5087563919 @default.
• W4361946181 hasAuthorship W4361946181A5091148741 @default.
• W4361946181 hasBestOaLocation W43619461812 @default.
• W4361946181 hasConcept C104317684 @default.
• W4361946181 hasConcept C121608353 @default.
• W4361946181 hasConcept C126322002 @default.
• W4361946181 hasConcept C143998085 @default.
• W4361946181 hasConcept C150194340 @default.
• W4361946181 hasConcept C18431079 @default.
• W4361946181 hasConcept C2777622882 @default.
• W4361946181 hasConcept C2780210213 @default.
• W4361946181 hasConcept C2780258809 @default.
• W4361946181 hasConcept C502942594 @default.
• W4361946181 hasConcept C519581460 @default.
• W4361946181 hasConcept C54355233 @default.
• W4361946181 hasConcept C71924100 @default.
• W4361946181 hasConcept C86803240 @default.
• W4361946181 hasConceptScore W4361946181C104317684 @default.
• W4361946181 hasConceptScore W4361946181C121608353 @default.
• W4361946181 hasConceptScore W4361946181C126322002 @default.
• W4361946181 hasConceptScore W4361946181C143998085 @default.
• W4361946181 hasConceptScore W4361946181C150194340 @default.
• W4361946181 hasConceptScore W4361946181C18431079 @default.
• W4361946181 hasConceptScore W4361946181C2777622882 @default.
• W4361946181 hasConceptScore W4361946181C2780210213 @default.
• W4361946181 hasConceptScore W4361946181C2780258809 @default.
• W4361946181 hasConceptScore W4361946181C502942594 @default.
• W4361946181 hasConceptScore W4361946181C519581460 @default.
• W4361946181 hasConceptScore W4361946181C54355233 @default.
• W4361946181 hasConceptScore W4361946181C71924100 @default.
• W4361946181 hasConceptScore W4361946181C86803240 @default.
• W4361946181 hasLocation W43619461811 @default.
• W4361946181 hasLocation W43619461812 @default.
• W4361946181 hasOpenAccess W4361946181 @default.
• W4361946181 hasPrimaryLocation W43619461811 @default.
• W4361946181 hasRelatedWork W133898433 @default.
• W4361946181 hasRelatedWork W1969578744 @default.
• W4361946181 hasRelatedWork W2005537476 @default.
• W4361946181 hasRelatedWork W2089179463 @default.
• W4361946181 hasRelatedWork W2165480504 @default.
• W4361946181 hasRelatedWork W2171607164 @default.
• W4361946181 hasRelatedWork W2319496893 @default.
• W4361946181 hasRelatedWork W2376347278 @default.
• W4361946181 hasRelatedWork W2752933315 @default.
• W4361946181 hasRelatedWork W4311308018 @default.
• W4361946181 isParatext "false" @default.
• W4361946181 isRetracted "false" @default.
• W4361946181 workType "article" @default.