Matches in SemOpenAlex for { <https://semopenalex.org/work/W4361946229> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W4361946229 abstract "<div>Abstract<p><b>Purpose:</b> The clinical utility of circulating tumor DNA (ctDNA) monitoring has been shown in tumors that harbor highly recurrent mutations. Leiomyosarcoma represents a type of tumor with a wide spectrum of heterogeneous genomic abnormalities; thus, targeting hotspot mutations or a narrow genomic region for ctDNA detection may not be practical. Here, we demonstrate a combinatorial approach that integrates different sequencing protocols for the orthogonal detection of single-nucleotide variants (SNV), small indels, and copy-number alterations (CNA) in ctDNA.</p><p><b>Experimental Design:</b> We employed Cancer Personalized Profiling by deep Sequencing (CAPP-Seq) for the analysis of SNVs and indels, together with a genome-wide interrogation of CNAs by Genome Representation Profiling (GRP). We profiled 28 longitudinal plasma samples and 25 tumor specimens from 7 patients with leiomyosarcoma.</p><p><b>Results:</b> We detected ctDNA in 6 of 7 of these patients with >98% specificity for mutant allele fractions down to a level of 0.01%. We show that results from CAPP-Seq and GRP are highly concordant, and the combination of these methods allows for more comprehensive monitoring of ctDNA by profiling a wide spectrum of tumor-specific markers. By analyzing multiple tumor specimens in individual patients obtained from different sites and at different times during treatment, we observed clonal evolution of these tumors that was reflected by ctDNA profiles.</p><p><b>Conclusions:</b> Our strategy allows for the comprehensive monitoring of a broad spectrum of tumor-specific markers in plasma. Our approach may be clinically useful not only in leiomyosarcoma but also in other tumor types that lack recurrent genomic alterations. <i>Clin Cancer Res; 24(11); 2688–99. ©2018 AACR</i>.</p></div>" @default.
- W4361946229 created "2023-04-05" @default.
- W4361946229 creator A5001873561 @default.
- W4361946229 creator A5002498799 @default.
- W4361946229 creator A5006583313 @default.
- W4361946229 creator A5007420876 @default.
- W4361946229 creator A5015197719 @default.
- W4361946229 creator A5022982759 @default.
- W4361946229 creator A5026051688 @default.
- W4361946229 creator A5040935030 @default.
- W4361946229 creator A5044980457 @default.
- W4361946229 creator A5068716765 @default.
- W4361946229 creator A5076624501 @default.
- W4361946229 creator A5078534180 @default.
- W4361946229 creator A5078624074 @default.
- W4361946229 date "2023-03-31" @default.
- W4361946229 modified "2023-10-14" @default.
- W4361946229 title "Data from Combination Approach for Detecting Different Types of Alterations in Circulating Tumor DNA in Leiomyosarcoma" @default.
- W4361946229 doi "https://doi.org/10.1158/1078-0432.c.6527472" @default.
- W4361946229 hasPublicationYear "2023" @default.
- W4361946229 type Work @default.
- W4361946229 citedByCount "0" @default.
- W4361946229 crossrefType "posted-content" @default.
- W4361946229 hasAuthorship W4361946229A5001873561 @default.
- W4361946229 hasAuthorship W4361946229A5002498799 @default.
- W4361946229 hasAuthorship W4361946229A5006583313 @default.
- W4361946229 hasAuthorship W4361946229A5007420876 @default.
- W4361946229 hasAuthorship W4361946229A5015197719 @default.
- W4361946229 hasAuthorship W4361946229A5022982759 @default.
- W4361946229 hasAuthorship W4361946229A5026051688 @default.
- W4361946229 hasAuthorship W4361946229A5040935030 @default.
- W4361946229 hasAuthorship W4361946229A5044980457 @default.
- W4361946229 hasAuthorship W4361946229A5068716765 @default.
- W4361946229 hasAuthorship W4361946229A5076624501 @default.
- W4361946229 hasAuthorship W4361946229A5078534180 @default.
- W4361946229 hasAuthorship W4361946229A5078624074 @default.
- W4361946229 hasBestOaLocation W43619462292 @default.
- W4361946229 hasConcept C104317684 @default.
- W4361946229 hasConcept C119054055 @default.
- W4361946229 hasConcept C121608353 @default.
- W4361946229 hasConcept C135763542 @default.
- W4361946229 hasConcept C153209595 @default.
- W4361946229 hasConcept C153911025 @default.
- W4361946229 hasConcept C2781335228 @default.
- W4361946229 hasConcept C502942594 @default.
- W4361946229 hasConcept C51679486 @default.
- W4361946229 hasConcept C54355233 @default.
- W4361946229 hasConcept C552990157 @default.
- W4361946229 hasConcept C70721500 @default.
- W4361946229 hasConcept C86803240 @default.
- W4361946229 hasConceptScore W4361946229C104317684 @default.
- W4361946229 hasConceptScore W4361946229C119054055 @default.
- W4361946229 hasConceptScore W4361946229C121608353 @default.
- W4361946229 hasConceptScore W4361946229C135763542 @default.
- W4361946229 hasConceptScore W4361946229C153209595 @default.
- W4361946229 hasConceptScore W4361946229C153911025 @default.
- W4361946229 hasConceptScore W4361946229C2781335228 @default.
- W4361946229 hasConceptScore W4361946229C502942594 @default.
- W4361946229 hasConceptScore W4361946229C51679486 @default.
- W4361946229 hasConceptScore W4361946229C54355233 @default.
- W4361946229 hasConceptScore W4361946229C552990157 @default.
- W4361946229 hasConceptScore W4361946229C70721500 @default.
- W4361946229 hasConceptScore W4361946229C86803240 @default.
- W4361946229 hasLocation W43619462291 @default.
- W4361946229 hasLocation W43619462292 @default.
- W4361946229 hasOpenAccess W4361946229 @default.
- W4361946229 hasPrimaryLocation W43619462291 @default.
- W4361946229 hasRelatedWork W1745164747 @default.
- W4361946229 hasRelatedWork W1969127221 @default.
- W4361946229 hasRelatedWork W1994038182 @default.
- W4361946229 hasRelatedWork W2059819539 @default.
- W4361946229 hasRelatedWork W2098701170 @default.
- W4361946229 hasRelatedWork W2154453877 @default.
- W4361946229 hasRelatedWork W2169902298 @default.
- W4361946229 hasRelatedWork W2367148337 @default.
- W4361946229 hasRelatedWork W2752989390 @default.
- W4361946229 hasRelatedWork W3146850093 @default.
- W4361946229 isParatext "false" @default.
- W4361946229 isRetracted "false" @default.
- W4361946229 workType "article" @default.