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- W4361946269 abstract "<div>Abstract<p>Dysregulated metabolism is one of the key characteristics of cancer cells. The most prominent alterations are present during regulation of cell respiration, which leads to a switch from oxidative phosphorylation to aerobic glycolysis. This metabolic shift results in activation of numerous signaling and metabolic pathways supporting cell proliferation and survival. Recent progress in genetics and metabolomics has allowed us to take a closer look at the metabolic changes present in pheochromocytomas (PHEO) and paragangliomas (PGL). These neuroendocrine tumors often exhibit dysregulation of mitochondrial metabolism, which is driven by mutations in genes encoding Krebs cycle enzymes or by activation of hypoxia signaling. Present metabolic changes are involved in processes associated with tumorigenesis, invasiveness, metastasis, and resistance to various cancer therapies. In this review, we discuss the metabolic nature of PHEOs/PGLs and how unveiling the metabolic disturbances present in tumors could lead to identification of new biomarkers and personalized cancer therapies. <i>Clin Cancer Res; 22(20); 5001–11. ©2016 AACR</i>.</p><p>See all articles in this <i><a href=http://clincancerres.aacrjournals.org/content/22/20#CCRFocus target=_blank>CCR Focus</a></i> section, “Endocrine Cancers: Revising Paradigms.”</p></div>" @default.
- W4361946269 created "2023-04-05" @default.
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- W4361946269 date "2023-03-31" @default.
- W4361946269 modified "2023-10-14" @default.
- W4361946269 title "Data from Pheochromocytoma: The First Metabolic Endocrine Cancer" @default.
- W4361946269 doi "https://doi.org/10.1158/1078-0432.c.6526463" @default.
- W4361946269 hasPublicationYear "2023" @default.
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