FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4361946285> ?p ?o ?g. }

• W4361946285 abstract "<div>Abstract<p><b>Purpose:</b> The multiple mechanisms used by solid tumors to suppress tumor-specific immune responses are a major barrier to the success of adoptively transferred tumor-specific T cells. As viruses induce potent innate and adaptive immune responses, we hypothesized that the immunogenicity of viruses could be harnessed for the treatment of solid tumors if virus-specific T cells (VST) were modified with tumor-specific chimeric antigen receptors (CAR). We tested this hypothesis using VZV-specific T cells (VZVST) expressing a CAR for GD2, a disialoganglioside expressed on neuroblastoma and certain other tumors, so that the live-attenuated VZV vaccine could be used for <i>in vivo</i> stimulation.</p><p><b>Experimental Design:</b> We generated GMP-compliant, GD2.CAR-modified VZVSTs from healthy donors and cancer patients by stimulation of peripheral blood mononuclear cells with overlapping peptide libraries spanning selected VZV antigens, then tested their ability to recognize and kill GD2- and VZV antigen–expressing target cells.</p><p><b>Results:</b> Our choice of VZV antigens was validated by the observation that T cells specific for these antigens expanded <i>in vivo</i> after VZV vaccination. VZVSTs secreted cytokines in response to VZV antigens, killed VZV-infected target cells and limited infectious virus spread in autologous fibroblasts. However, while GD2.CAR–modified VZVSTs killed neuroblastoma cell lines on their first encounter, they failed to control tumor cells in subsequent cocultures. Despite this CAR-specific dysfunction, CAR-VZVSTs retained functional specificity for VZV antigens via their TCRs and GD2.CAR function was partially rescued by stimulation through the TCR or exposure to dendritic cell supernatants.</p><p><b>Conclusions:</b> Vaccination via the TCR may provide a means to reactivate CAR-T cells rendered dysfunctional by the tumor microenvironment (NCT01953900). <i>Clin Cancer Res; 23(14); 3499–509. ©2017 AACR</i>.</p></div>" @default.
• W4361946285 created "2023-04-05" @default.
• W4361946285 creator A5000490817 @default.
• W4361946285 creator A5005166350 @default.
• W4361946285 creator A5015760028 @default.
• W4361946285 creator A5017070005 @default.
• W4361946285 creator A5020956671 @default.
• W4361946285 creator A5023347677 @default.
• W4361946285 creator A5023649972 @default.
• W4361946285 creator A5044253645 @default.
• W4361946285 creator A5046119962 @default.
• W4361946285 creator A5057196933 @default.
• W4361946285 creator A5077204778 @default.
• W4361946285 creator A5087257662 @default.
• W4361946285 date "2023-03-31" @default.
• W4361946285 modified "2023-09-26" @default.
• W4361946285 title "Data from Vaccination Targeting Native Receptors to Enhance the Function and Proliferation of Chimeric Antigen Receptor (CAR)-Modified T Cells" @default.
• W4361946285 doi "https://doi.org/10.1158/1078-0432.c.6526298" @default.
• W4361946285 hasPublicationYear "2023" @default.
• W4361946285 type Work @default.
• W4361946285 citedByCount "0" @default.
• W4361946285 crossrefType "posted-content" @default.
• W4361946285 hasAuthorship W4361946285A5000490817 @default.
• W4361946285 hasAuthorship W4361946285A5005166350 @default.
• W4361946285 hasAuthorship W4361946285A5015760028 @default.
• W4361946285 hasAuthorship W4361946285A5017070005 @default.
• W4361946285 hasAuthorship W4361946285A5020956671 @default.
• W4361946285 hasAuthorship W4361946285A5023347677 @default.
• W4361946285 hasAuthorship W4361946285A5023649972 @default.
• W4361946285 hasAuthorship W4361946285A5044253645 @default.
• W4361946285 hasAuthorship W4361946285A5046119962 @default.
• W4361946285 hasAuthorship W4361946285A5057196933 @default.
• W4361946285 hasAuthorship W4361946285A5077204778 @default.
• W4361946285 hasAuthorship W4361946285A5087257662 @default.
• W4361946285 hasBestOaLocation W43619462852 @default.
• W4361946285 hasConcept C147483822 @default.
• W4361946285 hasConcept C159047783 @default.
• W4361946285 hasConcept C203014093 @default.
• W4361946285 hasConcept C2776090121 @default.
• W4361946285 hasConcept C2780868878 @default.
• W4361946285 hasConcept C3875195 @default.
• W4361946285 hasConcept C502942594 @default.
• W4361946285 hasConcept C86803240 @default.
• W4361946285 hasConcept C8891405 @default.
• W4361946285 hasConceptScore W4361946285C147483822 @default.
• W4361946285 hasConceptScore W4361946285C159047783 @default.
• W4361946285 hasConceptScore W4361946285C203014093 @default.
• W4361946285 hasConceptScore W4361946285C2776090121 @default.
• W4361946285 hasConceptScore W4361946285C2780868878 @default.
• W4361946285 hasConceptScore W4361946285C3875195 @default.
• W4361946285 hasConceptScore W4361946285C502942594 @default.
• W4361946285 hasConceptScore W4361946285C86803240 @default.
• W4361946285 hasConceptScore W4361946285C8891405 @default.
• W4361946285 hasLocation W43619462851 @default.
• W4361946285 hasLocation W43619462852 @default.
• W4361946285 hasOpenAccess W4361946285 @default.
• W4361946285 hasPrimaryLocation W43619462851 @default.
• W4361946285 hasRelatedWork W1481917790 @default.
• W4361946285 hasRelatedWork W1519040467 @default.
• W4361946285 hasRelatedWork W1974103061 @default.
• W4361946285 hasRelatedWork W1995017465 @default.
• W4361946285 hasRelatedWork W2009090497 @default.
• W4361946285 hasRelatedWork W2090698640 @default.
• W4361946285 hasRelatedWork W2220102944 @default.
• W4361946285 hasRelatedWork W2411712784 @default.
• W4361946285 hasRelatedWork W2888060141 @default.
• W4361946285 hasRelatedWork W3022872369 @default.
• W4361946285 isParatext "false" @default.
• W4361946285 isRetracted "false" @default.
• W4361946285 workType "article" @default.