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• W4361946667 abstract "<div>AbstractPurpose:<p>¹²⁴I-PU-H71 is an investigational first-in-class radiologic agent specific for imaging tumor epichaperome formations. The intracellular epichaperome forms under cellular stress and is a clinically validated oncotherapeutic target. We conducted a first-in-human study of microdose ¹²⁴I-PU-H71 for PET to study <i>in vivo</i> biodistribution, pharmacokinetics, metabolism, and safety; and the feasibility of epichaperome-targeted tumor imaging.</p>Experimental Design:<p>Adult patients with cancer (<i>n</i> = 30) received ¹²⁴I-PU-H71 tracer (201±12 MBq, <25 μg) intravenous bolus followed by PET/CT scans and blood radioassays.</p>Results:<p>¹²⁴I-PU-H71 PET detected tumors of different cancer types (breast, lymphoma, neuroblastoma, genitourinary, gynecologic, sarcoma, and pancreas). ¹²⁴I-PU-H71 was retained by tumors for several days while it cleared rapidly from bones, healthy soft tissues, and blood. Radiation dosimetry is favorable and patients suffered no adverse effects.</p>Conclusions:<p>Our first-in-human results demonstrate the safety and feasibility of noninvasive <i>in vivo</i> detection of tumor epichaperomes using ¹²⁴I-PU-H71 PET, supporting clinical development of PU-H71 and other epichaperome-targeted therapeutics.</p></div>" @default.
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• W4361946667 date "2023-03-31" @default.
• W4361946667 modified "2023-10-12" @default.
• W4361946667 title "Data from First-in-Human Trial of Epichaperome-Targeted PET in Patients with Cancer" @default.
• W4361946667 doi "https://doi.org/10.1158/1078-0432.c.6529761" @default.
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