FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4361946670> ?p ?o ?g. }

• W4361946670 abstract "<div>Abstract<p><b>Purpose:</b> Activation of <i>MET</i> oncogene as the result of amplification or activation mutation represents an emerging molecular target for cancer treatment. We comprehensively studied MET alterations and the clinicopathologic correlations in a large cohort of treatment-naïve non–small cell lung carcinoma (NSCLC).</p><p><b>Experimental Design:</b> Six hundred eighty-seven NSCLCs were tested for <i>MET</i> exon 14 splicing site mutation (<i>METΔ</i>14), DNA copy number alterations, and protein expression by Sanger sequencing, FISH, and IHC, respectively.</p><p><b>Results:</b> <i>METΔ</i>14 mutation was detected in 2.62% (18/687) of NSCLC. The mutation rates were 2.6% in adenocarcinoma, 4.8% in adenosquamous carcinoma, and 31.8% in sarcomatoid carcinoma. <i>METΔ</i>14 mutation was not detected in squamous cell carcinoma, large cell carcinoma, and lymphoepithelioma-like carcinoma but significantly enriched in sarcomatoid carcinoma (<i>P</i> < 0.001). <i>METΔ</i>14 occurred mutually exclusively with known driver mutations but tended to coexist with <i>MET</i> amplification or copy number gain (<i>P</i> < 0.001). Low-level <i>MET</i> amplification and polysomy might occur in the background of EGFR or KRAS mutation whereas high-level amplification (<i>MET</i>/CEP7 ratio ≥5) was mutually exclusive to the major driver genes except <i>METΔ</i>14. Oncogenic <i>METΔ</i>14 mutation and/or high-level amplification occurred in a total of 3.3% (23/687) of NSCLC and associated with higher MET protein expression. <i>METΔ</i>14 occurred more frequently in older patients whereas amplification was more common in ever-smokers. Both <i>METΔ</i>14 and high-level amplification were independent prognostic factors that predicted poorer survival by multivariable analysis.</p><p><b>Conclusions:</b> The high incidence of <i>METΔ</i>14 mutation in sarcomatoid carcinoma suggested that MET inhibition might benefit this specific subgroup of patients. <i>Clin Cancer Res; 22(12); 3048–56. ©2016 AACR</i>.</p><p><i>See related commentary by Drilon, p. 2832</i></p></div>" @default.
• W4361946670 created "2023-04-05" @default.
• W4361946670 creator A5008512793 @default.
• W4361946670 creator A5008638712 @default.
• W4361946670 creator A5010656186 @default.
• W4361946670 creator A5011364735 @default.
• W4361946670 creator A5011760131 @default.
• W4361946670 creator A5014783847 @default.
• W4361946670 creator A5016626831 @default.
• W4361946670 creator A5023378646 @default.
• W4361946670 creator A5032472515 @default.
• W4361946670 creator A5043722203 @default.
• W4361946670 creator A5045389290 @default.
• W4361946670 creator A5049505870 @default.
• W4361946670 creator A5050884242 @default.
• W4361946670 creator A5065859286 @default.
• W4361946670 creator A5066717752 @default.
• W4361946670 creator A5072671681 @default.
• W4361946670 date "2023-03-31" @default.
• W4361946670 modified "2023-09-27" @default.
• W4361946670 title "Data from <i>MET</i> Amplification and Exon 14 Splice Site Mutation Define Unique Molecular Subgroups of Non–Small Cell Lung Carcinoma with Poor Prognosis" @default.
• W4361946670 doi "https://doi.org/10.1158/1078-0432.c.6524124" @default.
• W4361946670 hasPublicationYear "2023" @default.
• W4361946670 type Work @default.
• W4361946670 citedByCount "0" @default.
• W4361946670 crossrefType "posted-content" @default.
• W4361946670 hasAuthorship W4361946670A5008512793 @default.
• W4361946670 hasAuthorship W4361946670A5008638712 @default.
• W4361946670 hasAuthorship W4361946670A5010656186 @default.
• W4361946670 hasAuthorship W4361946670A5011364735 @default.
• W4361946670 hasAuthorship W4361946670A5011760131 @default.
• W4361946670 hasAuthorship W4361946670A5014783847 @default.
• W4361946670 hasAuthorship W4361946670A5016626831 @default.
• W4361946670 hasAuthorship W4361946670A5023378646 @default.
• W4361946670 hasAuthorship W4361946670A5032472515 @default.
• W4361946670 hasAuthorship W4361946670A5043722203 @default.
• W4361946670 hasAuthorship W4361946670A5045389290 @default.
• W4361946670 hasAuthorship W4361946670A5049505870 @default.
• W4361946670 hasAuthorship W4361946670A5050884242 @default.
• W4361946670 hasAuthorship W4361946670A5065859286 @default.
• W4361946670 hasAuthorship W4361946670A5066717752 @default.
• W4361946670 hasAuthorship W4361946670A5072671681 @default.
• W4361946670 hasBestOaLocation W43619466702 @default.
• W4361946670 hasConcept C104317684 @default.
• W4361946670 hasConcept C121608353 @default.
• W4361946670 hasConcept C153911025 @default.
• W4361946670 hasConcept C2776512503 @default.
• W4361946670 hasConcept C2777546739 @default.
• W4361946670 hasConcept C2781182431 @default.
• W4361946670 hasConcept C36823959 @default.
• W4361946670 hasConcept C501734568 @default.
• W4361946670 hasConcept C502942594 @default.
• W4361946670 hasConcept C54355233 @default.
• W4361946670 hasConcept C71924100 @default.
• W4361946670 hasConcept C86803240 @default.
• W4361946670 hasConceptScore W4361946670C104317684 @default.
• W4361946670 hasConceptScore W4361946670C121608353 @default.
• W4361946670 hasConceptScore W4361946670C153911025 @default.
• W4361946670 hasConceptScore W4361946670C2776512503 @default.
• W4361946670 hasConceptScore W4361946670C2777546739 @default.
• W4361946670 hasConceptScore W4361946670C2781182431 @default.
• W4361946670 hasConceptScore W4361946670C36823959 @default.
• W4361946670 hasConceptScore W4361946670C501734568 @default.
• W4361946670 hasConceptScore W4361946670C502942594 @default.
• W4361946670 hasConceptScore W4361946670C54355233 @default.
• W4361946670 hasConceptScore W4361946670C71924100 @default.
• W4361946670 hasConceptScore W4361946670C86803240 @default.
• W4361946670 hasLocation W43619466701 @default.
• W4361946670 hasLocation W43619466702 @default.
• W4361946670 hasOpenAccess W4361946670 @default.
• W4361946670 hasPrimaryLocation W43619466701 @default.
• W4361946670 hasRelatedWork W1748335368 @default.
• W4361946670 hasRelatedWork W1964681864 @default.
• W4361946670 hasRelatedWork W2018380129 @default.
• W4361946670 hasRelatedWork W2038032297 @default.
• W4361946670 hasRelatedWork W2070385249 @default.
• W4361946670 hasRelatedWork W2335994552 @default.
• W4361946670 hasRelatedWork W2434214883 @default.
• W4361946670 hasRelatedWork W2473322630 @default.
• W4361946670 hasRelatedWork W2475257193 @default.
• W4361946670 hasRelatedWork W2962961055 @default.
• W4361946670 isParatext "false" @default.
• W4361946670 isRetracted "false" @default.
• W4361946670 workType "article" @default.