Matches in SemOpenAlex for { <https://semopenalex.org/work/W4361946869> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W4361946869 abstract "<div>AbstractPurpose:<p>Gastroesophageal adenocarcinoma (GEA) has a poor prognosis and few therapeutic options. Utilizing a 73-gene plasma-based next-generation sequencing (NGS) cell-free circulating tumor DNA (ctDNA-NGS) test, we sought to evaluate the role of ctDNA-NGS in guiding clinical decision-making in GEA.</p>Experimental Design:<p>We evaluated a large cohort (<i>n</i> = 2,140 tests; 1,630 patients) of ctDNA-NGS results (including 369 clinically annotated patients). Patients were assessed for genomic alteration (GA) distribution and correlation with clinicopathologic characteristics and outcomes.</p>Results:<p>Treatment history, tumor site, and disease burden dictated tumor-DNA shedding and consequent ctDNA-NGS maximum somatic variant allele frequency. Patients with locally advanced disease having detectable ctDNA postoperatively experienced inferior median disease-free survival (<i>P</i> = 0.03). The genomic landscape was similar but not identical to tissue-NGS, reflecting temporospatial molecular heterogeneity, with some targetable GAs identified at higher frequency via ctDNA-NGS compared with previous primary tumor-NGS cohorts. Patients with known microsatellite instability-high (MSI-High) tumors were robustly detected with ctDNA-NGS. Predictive biomarker assessment was optimized by incorporating tissue-NGS and ctDNA-NGS assessment in a complementary manner. HER2 inhibition demonstrated a profound survival benefit in <i>HER2</i>-amplified patients by ctDNA-NGS and/or tissue-NGS (median overall survival, 26.3 vs. 7.4 months; <i>P</i> = 0.002), as did EGFR inhibition in <i>EGFR</i>-amplified patients (median overall survival, 21.1 vs. 14.4 months; <i>P</i> = 0.01).</p>Conclusions:<p>ctDNA-NGS characterized GEA molecular heterogeneity and rendered important prognostic and predictive information, complementary to tissue-NGS.</p><p><i>See related commentary by Frankell and Smyth, p. 6893</i></p></div>" @default.
- W4361946869 created "2023-04-05" @default.
- W4361946869 creator A5000496000 @default.
- W4361946869 creator A5014411546 @default.
- W4361946869 creator A5015703898 @default.
- W4361946869 creator A5018079260 @default.
- W4361946869 creator A5019406140 @default.
- W4361946869 creator A5021069486 @default.
- W4361946869 creator A5025052150 @default.
- W4361946869 creator A5026351538 @default.
- W4361946869 creator A5048899616 @default.
- W4361946869 creator A5053992102 @default.
- W4361946869 creator A5061220833 @default.
- W4361946869 creator A5064708484 @default.
- W4361946869 creator A5074882255 @default.
- W4361946869 creator A5089382639 @default.
- W4361946869 date "2023-03-31" @default.
- W4361946869 modified "2023-10-16" @default.
- W4361946869 title "Data from Circulating Tumor DNA Sequencing Analysis of Gastroesophageal Adenocarcinoma" @default.
- W4361946869 doi "https://doi.org/10.1158/1078-0432.c.6529071" @default.
- W4361946869 hasPublicationYear "2023" @default.
- W4361946869 type Work @default.
- W4361946869 citedByCount "0" @default.
- W4361946869 crossrefType "posted-content" @default.
- W4361946869 hasAuthorship W4361946869A5000496000 @default.
- W4361946869 hasAuthorship W4361946869A5014411546 @default.
- W4361946869 hasAuthorship W4361946869A5015703898 @default.
- W4361946869 hasAuthorship W4361946869A5018079260 @default.
- W4361946869 hasAuthorship W4361946869A5019406140 @default.
- W4361946869 hasAuthorship W4361946869A5021069486 @default.
- W4361946869 hasAuthorship W4361946869A5025052150 @default.
- W4361946869 hasAuthorship W4361946869A5026351538 @default.
- W4361946869 hasAuthorship W4361946869A5048899616 @default.
- W4361946869 hasAuthorship W4361946869A5053992102 @default.
- W4361946869 hasAuthorship W4361946869A5061220833 @default.
- W4361946869 hasAuthorship W4361946869A5064708484 @default.
- W4361946869 hasAuthorship W4361946869A5074882255 @default.
- W4361946869 hasAuthorship W4361946869A5089382639 @default.
- W4361946869 hasBestOaLocation W43619468692 @default.
- W4361946869 hasConcept C104317684 @default.
- W4361946869 hasConcept C121608353 @default.
- W4361946869 hasConcept C126322002 @default.
- W4361946869 hasConcept C143998085 @default.
- W4361946869 hasConcept C180754005 @default.
- W4361946869 hasConcept C2779767149 @default.
- W4361946869 hasConcept C2781182431 @default.
- W4361946869 hasConcept C2781197716 @default.
- W4361946869 hasConcept C502942594 @default.
- W4361946869 hasConcept C51679486 @default.
- W4361946869 hasConcept C54355233 @default.
- W4361946869 hasConcept C552990157 @default.
- W4361946869 hasConcept C61320498 @default.
- W4361946869 hasConcept C71924100 @default.
- W4361946869 hasConcept C86803240 @default.
- W4361946869 hasConceptScore W4361946869C104317684 @default.
- W4361946869 hasConceptScore W4361946869C121608353 @default.
- W4361946869 hasConceptScore W4361946869C126322002 @default.
- W4361946869 hasConceptScore W4361946869C143998085 @default.
- W4361946869 hasConceptScore W4361946869C180754005 @default.
- W4361946869 hasConceptScore W4361946869C2779767149 @default.
- W4361946869 hasConceptScore W4361946869C2781182431 @default.
- W4361946869 hasConceptScore W4361946869C2781197716 @default.
- W4361946869 hasConceptScore W4361946869C502942594 @default.
- W4361946869 hasConceptScore W4361946869C51679486 @default.
- W4361946869 hasConceptScore W4361946869C54355233 @default.
- W4361946869 hasConceptScore W4361946869C552990157 @default.
- W4361946869 hasConceptScore W4361946869C61320498 @default.
- W4361946869 hasConceptScore W4361946869C71924100 @default.
- W4361946869 hasConceptScore W4361946869C86803240 @default.
- W4361946869 hasLocation W43619468691 @default.
- W4361946869 hasLocation W43619468692 @default.
- W4361946869 hasOpenAccess W4361946869 @default.
- W4361946869 hasPrimaryLocation W43619468691 @default.
- W4361946869 hasRelatedWork W1980321942 @default.
- W4361946869 hasRelatedWork W2000479887 @default.
- W4361946869 hasRelatedWork W2008153433 @default.
- W4361946869 hasRelatedWork W2057739827 @default.
- W4361946869 hasRelatedWork W2097014703 @default.
- W4361946869 hasRelatedWork W2141593700 @default.
- W4361946869 hasRelatedWork W2370772550 @default.
- W4361946869 hasRelatedWork W3120340770 @default.
- W4361946869 hasRelatedWork W4254054468 @default.
- W4361946869 hasRelatedWork W96924620 @default.
- W4361946869 isParatext "false" @default.
- W4361946869 isRetracted "false" @default.
- W4361946869 workType "article" @default.