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• W4361946969 abstract "<div>Abstract<p><b>Purpose:</b> Our goal was to evaluate the safety and toxicity of combining a PARP inhibitor, olaparib, with cetuximab and fractionated intensity-modulated radiotherapy for patients with locally advanced head and neck cancer and heavy smoking histories.</p><p><b>Patients and Methods:</b> Patients with ≥10 packs/year history of smoking were treated with olaparib at doses ranging from 25–200 mg orally twice daily beginning approximately 10 days prior to initiation of and with concurrent radiation (69.3 Gy in 33 fractions) using a time-to-event continual reassessment method model. Cetuximab was administered starting approximately 5 days prior to radiation per standard of care.</p><p><b>Results:</b> A total of 16 patients were entered onto the study, with 15 evaluable for acute toxicity. The most common treatment-related grade 3–4 side effects were radiation dermatitis and mucositis (38% and 69%, respectively). The MTD was determined to be 50 mg orally twice daily, but the recommended phase II dose was deemed to be 25 mg orally twice daily. At a median follow-up of 26 months, the actuarial median overall survival was 37 months, but was not reached for other endpoints. Two-year overall survival, progression-free survival, local control, and distant control rates were 72%, 63%, 72%, and 79%, respectively. Patients who continued to smoke during therapy experienced higher recurrence rates. <i>MYC</i> and <i>KMT2A</i> were identified as potential correlatives of response on gene amplification and mutational analysis.</p><p><b>Conclusions:</b> Olaparib at 25 mg orally twice daily with concurrent cetuximab and radiation was well tolerated with reduced dermatitis within the radiation field. Response rates were promising for this high-risk population. <i>Clin Cancer Res; 24(20); 4949–59. ©2018 AACR</i>.</p></div>" @default.
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• W4361946969 date "2023-03-31" @default.
• W4361946969 modified "2023-09-26" @default.
• W4361946969 title "Data from Final Report of a Phase I Trial of Olaparib with Cetuximab and Radiation for Heavy Smoker Patients with Locally Advanced Head and Neck Cancer" @default.
• W4361946969 doi "https://doi.org/10.1158/1078-0432.c.6528983" @default.
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