FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4361946989> ?p ?o ?g. }

• W4361946989 abstract "<div>AbstractPurpose:<p>Molecular mechanisms of acquired resistance to MET tyrosine kinase inhibitors (TKI) are poorly understood. We aimed to characterize the genomic mechanisms of resistance to type I and type II MET TKIs and their impact on sequential MET TKI therapy outcomes in patients with metastatic <i>MET</i> exon 14–mutant NSCLC.</p>Experimental Design:<p>Genomic alterations occurring at the time of progression on MET TKIs were studied using plasma and tissue next-generation sequencing (NGS).</p>Results:<p>A total of 20 patients had tissue or plasma available for analysis at the time of acquired resistance to a MET TKI. Genomic alterations known or suspected to be mechanisms of resistance were detected in 15 patients (75%). On-target acquired mechanisms of resistance, including single and polyclonal <i>MET</i> kinase domain mutations in codons H1094, G1163, L1195, D1228, Y1230, and high levels of amplification of the <i>MET</i> exon 14–mutant allele, were observed in 7 patients (35%). A number of off-target mechanisms of resistance were detected in 9 patients (45%), including <i>KRAS</i> mutations and amplifications in <i>KRAS, EGFR, HER3</i>, and <i>BRAF</i>; one case displayed both on- and off-target mechanisms of resistance. In 2 patients with on-target resistant mutations, switching between type I and type II MET TKIs resulted in second partial responses.</p>Conclusions:<p>On-target secondary mutations and activation of bypass signaling drive resistance to MET TKIs. A deeper understanding of these molecular mechanisms can support the development of sequential or combinatorial therapeutic strategies to overcome resistance.</p></div>" @default.
• W4361946989 created "2023-04-05" @default.
• W4361946989 creator A5010761253 @default.
• W4361946989 creator A5025940494 @default.
• W4361946989 creator A5027707247 @default.
• W4361946989 creator A5029785378 @default.
• W4361946989 creator A5030450694 @default.
• W4361946989 creator A5030622261 @default.
• W4361946989 creator A5030723830 @default.
• W4361946989 creator A5034426537 @default.
• W4361946989 creator A5042026464 @default.
• W4361946989 creator A5045665778 @default.
• W4361946989 creator A5048675362 @default.
• W4361946989 creator A5052689241 @default.
• W4361946989 creator A5055894069 @default.
• W4361946989 creator A5056573353 @default.
• W4361946989 creator A5065133327 @default.
• W4361946989 creator A5069854182 @default.
• W4361946989 creator A5073502819 @default.
• W4361946989 creator A5079325672 @default.
• W4361946989 creator A5080682658 @default.
• W4361946989 creator A5086249998 @default.
• W4361946989 creator A5088608111 @default.
• W4361946989 creator A5090956629 @default.
• W4361946989 creator A5091880579 @default.
• W4361946989 date "2023-03-31" @default.
• W4361946989 modified "2023-10-17" @default.
• W4361946989 title "Data from Molecular Mechanisms of Acquired Resistance to MET Tyrosine Kinase Inhibitors in Patients with MET Exon 14–Mutant NSCLC" @default.
• W4361946989 doi "https://doi.org/10.1158/1078-0432.c.6529956" @default.
• W4361946989 hasPublicationYear "2023" @default.
• W4361946989 type Work @default.
• W4361946989 citedByCount "0" @default.
• W4361946989 crossrefType "posted-content" @default.
• W4361946989 hasAuthorship W4361946989A5010761253 @default.
• W4361946989 hasAuthorship W4361946989A5025940494 @default.
• W4361946989 hasAuthorship W4361946989A5027707247 @default.
• W4361946989 hasAuthorship W4361946989A5029785378 @default.
• W4361946989 hasAuthorship W4361946989A5030450694 @default.
• W4361946989 hasAuthorship W4361946989A5030622261 @default.
• W4361946989 hasAuthorship W4361946989A5030723830 @default.
• W4361946989 hasAuthorship W4361946989A5034426537 @default.
• W4361946989 hasAuthorship W4361946989A5042026464 @default.
• W4361946989 hasAuthorship W4361946989A5045665778 @default.
• W4361946989 hasAuthorship W4361946989A5048675362 @default.
• W4361946989 hasAuthorship W4361946989A5052689241 @default.
• W4361946989 hasAuthorship W4361946989A5055894069 @default.
• W4361946989 hasAuthorship W4361946989A5056573353 @default.
• W4361946989 hasAuthorship W4361946989A5065133327 @default.
• W4361946989 hasAuthorship W4361946989A5069854182 @default.
• W4361946989 hasAuthorship W4361946989A5073502819 @default.
• W4361946989 hasAuthorship W4361946989A5079325672 @default.
• W4361946989 hasAuthorship W4361946989A5080682658 @default.
• W4361946989 hasAuthorship W4361946989A5086249998 @default.
• W4361946989 hasAuthorship W4361946989A5088608111 @default.
• W4361946989 hasAuthorship W4361946989A5090956629 @default.
• W4361946989 hasAuthorship W4361946989A5091880579 @default.
• W4361946989 hasConcept C104317684 @default.
• W4361946989 hasConcept C121608353 @default.
• W4361946989 hasConcept C143065580 @default.
• W4361946989 hasConcept C153911025 @default.
• W4361946989 hasConcept C207583985 @default.
• W4361946989 hasConcept C2781187634 @default.
• W4361946989 hasConcept C2994294914 @default.
• W4361946989 hasConcept C36823959 @default.
• W4361946989 hasConcept C42362537 @default.
• W4361946989 hasConcept C501734568 @default.
• W4361946989 hasConcept C502942594 @default.
• W4361946989 hasConcept C54355233 @default.
• W4361946989 hasConcept C62478195 @default.
• W4361946989 hasConcept C71924100 @default.
• W4361946989 hasConcept C86803240 @default.
• W4361946989 hasConceptScore W4361946989C104317684 @default.
• W4361946989 hasConceptScore W4361946989C121608353 @default.
• W4361946989 hasConceptScore W4361946989C143065580 @default.
• W4361946989 hasConceptScore W4361946989C153911025 @default.
• W4361946989 hasConceptScore W4361946989C207583985 @default.
• W4361946989 hasConceptScore W4361946989C2781187634 @default.
• W4361946989 hasConceptScore W4361946989C2994294914 @default.
• W4361946989 hasConceptScore W4361946989C36823959 @default.
• W4361946989 hasConceptScore W4361946989C42362537 @default.
• W4361946989 hasConceptScore W4361946989C501734568 @default.
• W4361946989 hasConceptScore W4361946989C502942594 @default.
• W4361946989 hasConceptScore W4361946989C54355233 @default.
• W4361946989 hasConceptScore W4361946989C62478195 @default.
• W4361946989 hasConceptScore W4361946989C71924100 @default.
• W4361946989 hasConceptScore W4361946989C86803240 @default.
• W4361946989 hasLocation W43619469891 @default.
• W4361946989 hasOpenAccess W4361946989 @default.
• W4361946989 hasPrimaryLocation W43619469891 @default.
• W4361946989 hasRelatedWork W1891634364 @default.
• W4361946989 hasRelatedWork W2016180814 @default.
• W4361946989 hasRelatedWork W2080937304 @default.
• W4361946989 hasRelatedWork W2379610755 @default.
• W4361946989 hasRelatedWork W3004655782 @default.
• W4361946989 hasRelatedWork W3009829673 @default.
• W4361946989 hasRelatedWork W4281804835 @default.
• W4361946989 hasRelatedWork W4361946989 @default.
• W4361946989 hasRelatedWork W4361956480 @default.
• W4361946989 hasRelatedWork W4361967638 @default.
• W4361946989 isParatext "false" @default.

• next