FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4361947269> ?p ?o ?g. }

• W4361947269 abstract "<div>AbstractPurpose:<p>To evaluate the tissue distribution and clinical significance of OX40 and OX40L in human non–small cell lung cancer (NSCLC).</p>Experimental Design:<p>Using multiplexed quantitative immunofluorescence, we conducted simultaneous and localized measurements of OX40 and OX40L proteins, major T-cell subsets, and conventional type 1 dendritic cells (cDC1) in 614 primary NSCLCs from three independent cohorts represented in tissue microarrays. We also measured OX40L protein in samples from a phase I clinical trial of intratumor administration of a lipid nanoparticle encapsulated mRNA encoding OX40L (mRNA-2416) in human solid tumors. Finally, we studied the OX40 pathway in 212 uterine/ovarian serous carcinomas.</p>Results:<p>OX40 protein was expressed in approximately 90% of NSCLCs, and OX40L was detected in approximately 10% of cases. Increased expression of OX40 was associated with higher CD4⁺ and CD8⁺ T lymphocytes, as well as cDC1s. Elevated expression of OX40L was consistently associated with increased CD4⁺ tumor-infiltrating lymphocytes and longer overall survival. No association was found between OX40 or OX40L levels and oncogenic driver mutations in EGFR and KRAS in lung adenocarcinomas. Delivering OX40L mRNA using intratumor mRNA-2416 injection mediated increased local OX40L protein levels that was most prominent in a patient with ovarian serous carcinoma. Detectable OX40L protein levels were observed in 15% of primary uterine/ovarian serous malignancies and associated with longer survival.</p>Conclusions:<p>The OX40 pathway is expressed in a fraction of NSCLCs and is associated with a favorable immune contexture. Although OX40L is uncommonly expressed in NSCLC and serous malignancies, it is associated with better prognosis and can be introduced using exogenous mRNA.</p></div>" @default.
• W4361947269 created "2023-04-05" @default.
• W4361947269 creator A5003425714 @default.
• W4361947269 creator A5014997857 @default.
• W4361947269 creator A5039115208 @default.
• W4361947269 creator A5049509860 @default.
• W4361947269 creator A5058785928 @default.
• W4361947269 creator A5062402995 @default.
• W4361947269 creator A5076615112 @default.
• W4361947269 creator A5088227922 @default.
• W4361947269 date "2023-03-31" @default.
• W4361947269 modified "2023-09-26" @default.
• W4361947269 title "Data from Spatial Mapping and Immunomodulatory Role of the OX40/OX40L Pathway in Human Non–Small Cell Lung Cancer" @default.
• W4361947269 doi "https://doi.org/10.1158/1078-0432.c.6530624" @default.
• W4361947269 hasPublicationYear "2023" @default.
• W4361947269 type Work @default.
• W4361947269 citedByCount "0" @default.
• W4361947269 crossrefType "posted-content" @default.
• W4361947269 hasAuthorship W4361947269A5003425714 @default.
• W4361947269 hasAuthorship W4361947269A5014997857 @default.
• W4361947269 hasAuthorship W4361947269A5039115208 @default.
• W4361947269 hasAuthorship W4361947269A5049509860 @default.
• W4361947269 hasAuthorship W4361947269A5058785928 @default.
• W4361947269 hasAuthorship W4361947269A5062402995 @default.
• W4361947269 hasAuthorship W4361947269A5076615112 @default.
• W4361947269 hasAuthorship W4361947269A5088227922 @default.
• W4361947269 hasBestOaLocation W43619472692 @default.
• W4361947269 hasConcept C104317684 @default.
• W4361947269 hasConcept C105580179 @default.
• W4361947269 hasConcept C121608353 @default.
• W4361947269 hasConcept C126322002 @default.
• W4361947269 hasConcept C142724271 @default.
• W4361947269 hasConcept C147483822 @default.
• W4361947269 hasConcept C150173356 @default.
• W4361947269 hasConcept C153911025 @default.
• W4361947269 hasConcept C167672396 @default.
• W4361947269 hasConcept C203014093 @default.
• W4361947269 hasConcept C2780427987 @default.
• W4361947269 hasConcept C2781187634 @default.
• W4361947269 hasConcept C502942594 @default.
• W4361947269 hasConcept C526805850 @default.
• W4361947269 hasConcept C55493867 @default.
• W4361947269 hasConcept C71924100 @default.
• W4361947269 hasConcept C86803240 @default.
• W4361947269 hasConceptScore W4361947269C104317684 @default.
• W4361947269 hasConceptScore W4361947269C105580179 @default.
• W4361947269 hasConceptScore W4361947269C121608353 @default.
• W4361947269 hasConceptScore W4361947269C126322002 @default.
• W4361947269 hasConceptScore W4361947269C142724271 @default.
• W4361947269 hasConceptScore W4361947269C147483822 @default.
• W4361947269 hasConceptScore W4361947269C150173356 @default.
• W4361947269 hasConceptScore W4361947269C153911025 @default.
• W4361947269 hasConceptScore W4361947269C167672396 @default.
• W4361947269 hasConceptScore W4361947269C203014093 @default.
• W4361947269 hasConceptScore W4361947269C2780427987 @default.
• W4361947269 hasConceptScore W4361947269C2781187634 @default.
• W4361947269 hasConceptScore W4361947269C502942594 @default.
• W4361947269 hasConceptScore W4361947269C526805850 @default.
• W4361947269 hasConceptScore W4361947269C55493867 @default.
• W4361947269 hasConceptScore W4361947269C71924100 @default.
• W4361947269 hasConceptScore W4361947269C86803240 @default.
• W4361947269 hasLocation W43619472691 @default.
• W4361947269 hasLocation W43619472692 @default.
• W4361947269 hasOpenAccess W4361947269 @default.
• W4361947269 hasPrimaryLocation W43619472691 @default.
• W4361947269 hasRelatedWork W2032547559 @default.
• W4361947269 hasRelatedWork W2061291895 @default.
• W4361947269 hasRelatedWork W2095050670 @default.
• W4361947269 hasRelatedWork W2185490347 @default.
• W4361947269 hasRelatedWork W2359264551 @default.
• W4361947269 hasRelatedWork W2585863243 @default.
• W4361947269 hasRelatedWork W2954418767 @default.
• W4361947269 hasRelatedWork W3037088934 @default.
• W4361947269 hasRelatedWork W4213077763 @default.
• W4361947269 hasRelatedWork W4288746114 @default.
• W4361947269 isParatext "false" @default.
• W4361947269 isRetracted "false" @default.
• W4361947269 workType "article" @default.