FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4361947419> ?p ?o ?g. }

• W4361947419 abstract "<div>AbstractPurpose:<p>Tumor mutational burden (TMB) has been shown to be predictive of survival benefit in patients with non–small cell lung cancer (NSCLC) treated with immune checkpoint inhibitors. Measuring TMB in the blood (bTMB) using circulating cell-free tumor DNA (ctDNA) offers practical advantages compared with TMB measurement in tissue (tTMB); however, there is a need for validated assays and identification of optimal cutoffs. We describe the analytic validation of a new bTMB algorithm and its clinical utility using data from the phase III MYSTIC trial.</p>Patients and Methods:<p>The dataset used for the clinical validation was from MYSTIC, which evaluated first-line durvalumab (anti–PD-L1 antibody) ± tremelimumab (anticytotoxic T-lymphocyte-associated antigen-4 antibody) or chemotherapy for metastatic NSCLC. bTMB and tTMB were evaluated using the GuardantOMNI and FoundationOne CDx assays, respectively. A Cox proportional hazards model and minimal <i>P</i> value cross-validation approach were used to identify the optimal bTMB cutoff.</p>Results:<p>In MYSTIC, somatic mutations could be detected in ctDNA extracted from plasma samples in a majority of patients, allowing subsequent calculation of bTMB. The success rate for obtaining valid TMB scores was higher for bTMB (809/1,001; 81%) than for tTMB (460/735; 63%). Minimal <i>P</i> value cross-validation analysis confirmed the selection of bTMB ≥20 mutations per megabase (mut/Mb) as the optimal cutoff for clinical benefit with durvalumab + tremelimumab.</p>Conclusions:<p>Our study demonstrates the feasibility, accuracy, and reproducibility of the GuardantOMNI ctDNA platform for quantifying bTMB from plasma samples. Using the new bTMB algorithm and an optimal bTMB cutoff of ≥20 mut/Mb, high bTMB was predictive of clinical benefit with durvalumab + tremelimumab versus chemotherapy.</p></div>" @default.
• W4361947419 created "2023-04-05" @default.
• W4361947419 creator A5009504777 @default.
• W4361947419 creator A5009693743 @default.
• W4361947419 creator A5021748826 @default.
• W4361947419 creator A5023592104 @default.
• W4361947419 creator A5031167598 @default.
• W4361947419 creator A5038897823 @default.
• W4361947419 creator A5046158954 @default.
• W4361947419 creator A5054365404 @default.
• W4361947419 creator A5056194172 @default.
• W4361947419 creator A5060470951 @default.
• W4361947419 creator A5063300526 @default.
• W4361947419 creator A5063821551 @default.
• W4361947419 creator A5073857588 @default.
• W4361947419 creator A5075877134 @default.
• W4361947419 creator A5088864413 @default.
• W4361947419 date "2023-03-31" @default.
• W4361947419 modified "2023-09-26" @default.
• W4361947419 title "Data from A Blood-based Assay for Assessment of Tumor Mutational Burden in First-line Metastatic NSCLC Treatment: Results from the MYSTIC Study" @default.
• W4361947419 doi "https://doi.org/10.1158/1078-0432.c.6530705" @default.
• W4361947419 hasPublicationYear "2023" @default.
• W4361947419 type Work @default.
• W4361947419 citedByCount "0" @default.
• W4361947419 crossrefType "posted-content" @default.
• W4361947419 hasAuthorship W4361947419A5009504777 @default.
• W4361947419 hasAuthorship W4361947419A5009693743 @default.
• W4361947419 hasAuthorship W4361947419A5021748826 @default.
• W4361947419 hasAuthorship W4361947419A5023592104 @default.
• W4361947419 hasAuthorship W4361947419A5031167598 @default.
• W4361947419 hasAuthorship W4361947419A5038897823 @default.
• W4361947419 hasAuthorship W4361947419A5046158954 @default.
• W4361947419 hasAuthorship W4361947419A5054365404 @default.
• W4361947419 hasAuthorship W4361947419A5056194172 @default.
• W4361947419 hasAuthorship W4361947419A5060470951 @default.
• W4361947419 hasAuthorship W4361947419A5063300526 @default.
• W4361947419 hasAuthorship W4361947419A5063821551 @default.
• W4361947419 hasAuthorship W4361947419A5073857588 @default.
• W4361947419 hasAuthorship W4361947419A5075877134 @default.
• W4361947419 hasAuthorship W4361947419A5088864413 @default.
• W4361947419 hasBestOaLocation W43619474192 @default.
• W4361947419 hasConcept C126322002 @default.
• W4361947419 hasConcept C143998085 @default.
• W4361947419 hasConcept C2776256026 @default.
• W4361947419 hasConcept C71924100 @default.
• W4361947419 hasConceptScore W4361947419C126322002 @default.
• W4361947419 hasConceptScore W4361947419C143998085 @default.
• W4361947419 hasConceptScore W4361947419C2776256026 @default.
• W4361947419 hasConceptScore W4361947419C71924100 @default.
• W4361947419 hasLocation W43619474191 @default.
• W4361947419 hasLocation W43619474192 @default.
• W4361947419 hasOpenAccess W4361947419 @default.
• W4361947419 hasPrimaryLocation W43619474191 @default.
• W4361947419 hasRelatedWork W1967103478 @default.
• W4361947419 hasRelatedWork W2032912323 @default.
• W4361947419 hasRelatedWork W2148097028 @default.
• W4361947419 hasRelatedWork W2365632055 @default.
• W4361947419 hasRelatedWork W2372561159 @default.
• W4361947419 hasRelatedWork W2375344515 @default.
• W4361947419 hasRelatedWork W2375392632 @default.
• W4361947419 hasRelatedWork W2380382254 @default.
• W4361947419 hasRelatedWork W2390152934 @default.
• W4361947419 hasRelatedWork W2412727163 @default.
• W4361947419 isParatext "false" @default.
• W4361947419 isRetracted "false" @default.
• W4361947419 workType "article" @default.