FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4361948141> ?p ?o ?g. }

• W4361948141 abstract "<div>AbstractPurpose:<p>Modified FOLFIRINOX (mFFX) and gemcitabine/nab-paclitaxel (GnP) remain standard first-line options for patients with advanced pancreatic ductal adenocarcinoma (PDAC). Human equilibrative nucleoside transporter 1 (hENT1) was hypothesized to be a biomarker of gemcitabine in the adjuvant setting, with conflicting results. In this study, we explore hENT1 mRNA expression as a predictive biomarker in advanced PDAC.</p>Experimental Design:<p>COMPASS was a prospective observational trial of patients with advanced PDAC. A biopsy was required prior to initiating chemotherapy, as determined by treating physician. Biopsies underwent laser capture microdissection prior to whole genome and RNA sequencing. The cut-off thresholds for hENT1 expression were determined using the maximal <i>χ</i>² statistic.</p>Results:<p>253 patients were included in the analyses with a median follow-up of 32 months, with 138 patients receiving mFFX and 92 receiving GnP. In the intention to treat population, median overall survival (OS) was 10.0 months in hENT1^high versus 7.9 months in hENT1^low (<i>P</i> = 0.02). In patients receiving mFFX, there was no difference in overall response rate (ORR; 35% vs. 28%, <i>P</i> = 0.56) or median OS (10.6 vs. 10.5 months, <i>P</i> = 0.45). However, in patients treated with GnP, the ORR was significantly higher in hENT1^high compared with hENT1^low tumors (43% vs. 21%, <i>P</i> = 0.038). Median OS in this GnP-treated cohort was 10.6 months in hENT1^high versus 6.7 months hENT1^low (<i>P</i> < 0.001). In an interaction analysis, hENT1 was predictive of treatment response to GnP (interaction <i>P</i> = 0.002).</p>Conclusions:<p>In advanced PDAC, hENT1 mRNA expression predicts ORR and OS in patients receiving GnP.</p></div>" @default.
• W4361948141 created "2023-04-05" @default.
• W4361948141 creator A5000583912 @default.
• W4361948141 creator A5009452194 @default.
• W4361948141 creator A5012095302 @default.
• W4361948141 creator A5016377624 @default.
• W4361948141 creator A5017021482 @default.
• W4361948141 creator A5031817257 @default.
• W4361948141 creator A5032367500 @default.
• W4361948141 creator A5035600919 @default.
• W4361948141 creator A5037486865 @default.
• W4361948141 creator A5052068951 @default.
• W4361948141 creator A5053818648 @default.
• W4361948141 creator A5055984590 @default.
• W4361948141 creator A5056727641 @default.
• W4361948141 creator A5061402791 @default.
• W4361948141 creator A5068644454 @default.
• W4361948141 creator A5071219496 @default.
• W4361948141 creator A5080925994 @default.
• W4361948141 creator A5081545818 @default.
• W4361948141 creator A5087178283 @default.
• W4361948141 creator A5088325035 @default.
• W4361948141 creator A5091747658 @default.
• W4361948141 creator A5091767516 @default.
• W4361948141 date "2023-04-01" @default.
• W4361948141 modified "2023-10-11" @default.
• W4361948141 title "Data from hENT1 Expression Predicts Response to Gemcitabine and Nab-Paclitaxel in Advanced Pancreatic Ductal Adenocarcinoma" @default.
• W4361948141 doi "https://doi.org/10.1158/1078-0432.c.6532926" @default.
• W4361948141 hasPublicationYear "2023" @default.
• W4361948141 type Work @default.
• W4361948141 citedByCount "0" @default.
• W4361948141 crossrefType "posted-content" @default.
• W4361948141 hasAuthorship W4361948141A5000583912 @default.
• W4361948141 hasAuthorship W4361948141A5009452194 @default.
• W4361948141 hasAuthorship W4361948141A5012095302 @default.
• W4361948141 hasAuthorship W4361948141A5016377624 @default.
• W4361948141 hasAuthorship W4361948141A5017021482 @default.
• W4361948141 hasAuthorship W4361948141A5031817257 @default.
• W4361948141 hasAuthorship W4361948141A5032367500 @default.
• W4361948141 hasAuthorship W4361948141A5035600919 @default.
• W4361948141 hasAuthorship W4361948141A5037486865 @default.
• W4361948141 hasAuthorship W4361948141A5052068951 @default.
• W4361948141 hasAuthorship W4361948141A5053818648 @default.
• W4361948141 hasAuthorship W4361948141A5055984590 @default.
• W4361948141 hasAuthorship W4361948141A5056727641 @default.
• W4361948141 hasAuthorship W4361948141A5061402791 @default.
• W4361948141 hasAuthorship W4361948141A5068644454 @default.
• W4361948141 hasAuthorship W4361948141A5071219496 @default.
• W4361948141 hasAuthorship W4361948141A5080925994 @default.
• W4361948141 hasAuthorship W4361948141A5081545818 @default.
• W4361948141 hasAuthorship W4361948141A5087178283 @default.
• W4361948141 hasAuthorship W4361948141A5088325035 @default.
• W4361948141 hasAuthorship W4361948141A5091747658 @default.
• W4361948141 hasAuthorship W4361948141A5091767516 @default.
• W4361948141 hasBestOaLocation W43619481412 @default.
• W4361948141 hasConcept C121608353 @default.
• W4361948141 hasConcept C126322002 @default.
• W4361948141 hasConcept C143998085 @default.
• W4361948141 hasConcept C2776694085 @default.
• W4361948141 hasConcept C2777148230 @default.
• W4361948141 hasConcept C2780258809 @default.
• W4361948141 hasConcept C2780259306 @default.
• W4361948141 hasConcept C2781197716 @default.
• W4361948141 hasConcept C2908647359 @default.
• W4361948141 hasConcept C526805850 @default.
• W4361948141 hasConcept C55493867 @default.
• W4361948141 hasConcept C71924100 @default.
• W4361948141 hasConcept C86803240 @default.
• W4361948141 hasConcept C90924648 @default.
• W4361948141 hasConcept C99454951 @default.
• W4361948141 hasConceptScore W4361948141C121608353 @default.
• W4361948141 hasConceptScore W4361948141C126322002 @default.
• W4361948141 hasConceptScore W4361948141C143998085 @default.
• W4361948141 hasConceptScore W4361948141C2776694085 @default.
• W4361948141 hasConceptScore W4361948141C2777148230 @default.
• W4361948141 hasConceptScore W4361948141C2780258809 @default.
• W4361948141 hasConceptScore W4361948141C2780259306 @default.
• W4361948141 hasConceptScore W4361948141C2781197716 @default.
• W4361948141 hasConceptScore W4361948141C2908647359 @default.
• W4361948141 hasConceptScore W4361948141C526805850 @default.
• W4361948141 hasConceptScore W4361948141C55493867 @default.
• W4361948141 hasConceptScore W4361948141C71924100 @default.
• W4361948141 hasConceptScore W4361948141C86803240 @default.
• W4361948141 hasConceptScore W4361948141C90924648 @default.
• W4361948141 hasConceptScore W4361948141C99454951 @default.
• W4361948141 hasLocation W43619481411 @default.
• W4361948141 hasLocation W43619481412 @default.
• W4361948141 hasOpenAccess W4361948141 @default.
• W4361948141 hasPrimaryLocation W43619481411 @default.
• W4361948141 hasRelatedWork W2022709036 @default.
• W4361948141 hasRelatedWork W2115275439 @default.
• W4361948141 hasRelatedWork W2599910524 @default.
• W4361948141 hasRelatedWork W2721585150 @default.
• W4361948141 hasRelatedWork W2898505318 @default.
• W4361948141 hasRelatedWork W2910090032 @default.
• W4361948141 hasRelatedWork W3008650849 @default.
• W4361948141 hasRelatedWork W3143800975 @default.
• W4361948141 hasRelatedWork W3184807956 @default.
• W4361948141 hasRelatedWork W4380150473 @default.
• W4361948141 isParatext "false" @default.

• next