FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4361948412> ?p ?o ?g. }

• W4361948412 abstract "<div>Abstract<p><b>Purpose:</b> Loss of p53 function in urothelial cell carcinoma (UCC) by mutation or inactivation disrupts normal cell cycle checkpoints, generating a favorable milieu for genomic instability, a hallmark of UCC. The aim of this study was to characterize novel DNA copy number changes to identify putative therapeutic targets.</p><p><b>Experimental Design:</b> We report our findings using array comparative genomic hybridization on a whole-genome BAC/PAC/cosmid array with a median clone interval of 0.97 Mb to study a series of UCC cases. <i>TP53</i> status was determined by direct sequencing, and an in-house tissue microarray was constructed to identify protein expression of target genes.</p><p><b>Results:</b> Array comparative genomic hybridization allowed identification of novel regions of copy number changes in addition to those already known from previous studies. A novel amplification previously unreported in UCC was identified at 1q32. A chromosome 1 tile path array was used to analyze tumors that showed gains and amplification; the <i>mouse double minute 4</i> (<i>MDM4</i>) homologue was identified as the amplified gene. <i>MDM4</i> mRNA expression correlated with copy number and tumor grade. Copy number changes of <i>MDM4</i> and <i>MDM2</i> occurred exclusively in tumors with wild-type p53. Overexpression of <i>MDM4</i> corresponded to disruption of p53 transcriptional activity. Immunohistochemistry on an independent series by tissue microarray identified an inverse relationship between Mdm4 and Mdm2, with Mdm4 expression highest in invasive UCC.</p><p><b>Conclusion:</b> The data indicate that gain/amplification and overexpression of <i>MDM4</i> is a novel molecular mechanism by which a subset of UCC escapes p53-dependent growth control, thus providing new avenues for therapeutic intervention.</p></div>" @default.
• W4361948412 created "2023-04-05" @default.
• W4361948412 creator A5021109473 @default.
• W4361948412 creator A5027864745 @default.
• W4361948412 creator A5045338107 @default.
• W4361948412 creator A5047188789 @default.
• W4361948412 creator A5055117068 @default.
• W4361948412 creator A5066919301 @default.
• W4361948412 creator A5069947302 @default.
• W4361948412 creator A5083342160 @default.
• W4361948412 creator A5086206117 @default.
• W4361948412 creator A5089060804 @default.
• W4361948412 creator A5090783984 @default.
• W4361948412 date "2023-03-31" @default.
• W4361948412 modified "2023-10-17" @default.
• W4361948412 title "Data from High-Resolution Array-Based Comparative Genomic Hybridization of Bladder Cancers Identifies <i>Mouse Double Minute 4</i> (<i>MDM4</i>) as an Amplification Target Exclusive of <i>MDM2</i> and <i>TP53</i>" @default.
• W4361948412 doi "https://doi.org/10.1158/1078-0432.c.6516990.v1" @default.
• W4361948412 hasPublicationYear "2023" @default.
• W4361948412 type Work @default.
• W4361948412 citedByCount "0" @default.
• W4361948412 crossrefType "posted-content" @default.
• W4361948412 hasAuthorship W4361948412A5021109473 @default.
• W4361948412 hasAuthorship W4361948412A5027864745 @default.
• W4361948412 hasAuthorship W4361948412A5045338107 @default.
• W4361948412 hasAuthorship W4361948412A5047188789 @default.
• W4361948412 hasAuthorship W4361948412A5055117068 @default.
• W4361948412 hasAuthorship W4361948412A5066919301 @default.
• W4361948412 hasAuthorship W4361948412A5069947302 @default.
• W4361948412 hasAuthorship W4361948412A5083342160 @default.
• W4361948412 hasAuthorship W4361948412A5086206117 @default.
• W4361948412 hasAuthorship W4361948412A5089060804 @default.
• W4361948412 hasAuthorship W4361948412A5090783984 @default.
• W4361948412 hasBestOaLocation W43619484122 @default.
• W4361948412 hasConcept C104317684 @default.
• W4361948412 hasConcept C124942203 @default.
• W4361948412 hasConcept C141231307 @default.
• W4361948412 hasConcept C143425029 @default.
• W4361948412 hasConcept C153911025 @default.
• W4361948412 hasConcept C178169997 @default.
• W4361948412 hasConcept C54355233 @default.
• W4361948412 hasConcept C552990157 @default.
• W4361948412 hasConcept C86803240 @default.
• W4361948412 hasConceptScore W4361948412C104317684 @default.
• W4361948412 hasConceptScore W4361948412C124942203 @default.
• W4361948412 hasConceptScore W4361948412C141231307 @default.
• W4361948412 hasConceptScore W4361948412C143425029 @default.
• W4361948412 hasConceptScore W4361948412C153911025 @default.
• W4361948412 hasConceptScore W4361948412C178169997 @default.
• W4361948412 hasConceptScore W4361948412C54355233 @default.
• W4361948412 hasConceptScore W4361948412C552990157 @default.
• W4361948412 hasConceptScore W4361948412C86803240 @default.
• W4361948412 hasLocation W43619484121 @default.
• W4361948412 hasLocation W43619484122 @default.
• W4361948412 hasOpenAccess W4361948412 @default.
• W4361948412 hasPrimaryLocation W43619484121 @default.
• W4361948412 hasRelatedWork W1828691184 @default.
• W4361948412 hasRelatedWork W1991523530 @default.
• W4361948412 hasRelatedWork W2001677368 @default.
• W4361948412 hasRelatedWork W2002128513 @default.
• W4361948412 hasRelatedWork W2020824267 @default.
• W4361948412 hasRelatedWork W2057739827 @default.
• W4361948412 hasRelatedWork W2120393042 @default.
• W4361948412 hasRelatedWork W2123463087 @default.
• W4361948412 hasRelatedWork W2171277769 @default.
• W4361948412 hasRelatedWork W2092874662 @default.
• W4361948412 isParatext "false" @default.
• W4361948412 isRetracted "false" @default.
• W4361948412 workType "article" @default.