FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4361948772> ?p ?o ?g. }

• W4361948772 abstract "<div>Abstract<p><b>Background:</b> We previously developed a prognostic classifier using the expression levels of <i>BRCA1, HIF1A, DLC1</i>, and <i>XPO1</i> that identified stage I lung adenocarcinoma patients with a high risk of relapse. That study evaluated patients in five independent cohorts from various regions of the world. In an attempt to further validate the classifier, we have used a meta-analysis–based approach to study 12 cohorts consisting of 1,069 tumor–node–metastasis stage I lung adenocarcinoma patients from every suitable, publically available dataset.</p><p><b>Methods:</b> Cohorts were obtained through a systematic search of public gene expression datasets. These data were used to calculate the risk score using the previously published 4-gene risk model. A fixed effect meta-analysis model was used to generate a pooled estimate for all cohorts.</p><p><b>Results:</b> The classifier was associated with prognosis in 10 of the 12 cohorts (<i>P</i> < 0.05). This association was highly consistent regardless of the ethnic diversity or microarray platform. The pooled estimate demonstrated that patients classified as high risk had worse overall survival for all stage I [HR, 2.66; 95% confidence interval (CI), 1.93–3.67; <i>P</i> < 0.0001] patients and in stratified analyses of stage IA (HR, 2.69; 95% CI, 1.66–4.35; <i>P</i> < 0.0001) and stage IB (HR, 2.69; 95% CI, 1.74–4.16; <i>P</i> < 0.0001) patients.</p><p><b>Conclusions:</b> The 4-gene classifier provides independent prognostic stratification of stage IA and stage IB patients beyond conventional clinical factors.</p><p><b>Impact:</b> Our results suggest that the 4-gene classifier may assist clinicians in decisions about the postoperative management of early-stage lung adenocarcinoma patients. <i>Cancer Epidemiol Biomarkers Prev; 23(12); 2884–94. ©2014 AACR</i>.</p></div>" @default.
• W4361948772 created "2023-04-05" @default.
• W4361948772 creator A5016853321 @default.
• W4361948772 creator A5025520229 @default.
• W4361948772 creator A5035379638 @default.
• W4361948772 creator A5048636381 @default.
• W4361948772 creator A5050126669 @default.
• W4361948772 creator A5070619391 @default.
• W4361948772 creator A5071696225 @default.
• W4361948772 creator A5091148741 @default.
• W4361948772 date "2023-03-31" @default.
• W4361948772 modified "2023-09-26" @default.
• W4361948772 title "Data from The Expression of Four Genes as a Prognostic Classifier for Stage I Lung Adenocarcinoma in 12 Independent Cohorts" @default.
• W4361948772 doi "https://doi.org/10.1158/1055-9965.c.6516372.v1" @default.
• W4361948772 hasPublicationYear "2023" @default.
• W4361948772 type Work @default.
• W4361948772 citedByCount "0" @default.
• W4361948772 crossrefType "posted-content" @default.
• W4361948772 hasAuthorship W4361948772A5016853321 @default.
• W4361948772 hasAuthorship W4361948772A5025520229 @default.
• W4361948772 hasAuthorship W4361948772A5035379638 @default.
• W4361948772 hasAuthorship W4361948772A5048636381 @default.
• W4361948772 hasAuthorship W4361948772A5050126669 @default.
• W4361948772 hasAuthorship W4361948772A5070619391 @default.
• W4361948772 hasAuthorship W4361948772A5071696225 @default.
• W4361948772 hasAuthorship W4361948772A5091148741 @default.
• W4361948772 hasBestOaLocation W43619487722 @default.
• W4361948772 hasConcept C121608353 @default.
• W4361948772 hasConcept C126322002 @default.
• W4361948772 hasConcept C143998085 @default.
• W4361948772 hasConcept C2781182431 @default.
• W4361948772 hasConcept C44249647 @default.
• W4361948772 hasConcept C71924100 @default.
• W4361948772 hasConceptScore W4361948772C121608353 @default.
• W4361948772 hasConceptScore W4361948772C126322002 @default.
• W4361948772 hasConceptScore W4361948772C143998085 @default.
• W4361948772 hasConceptScore W4361948772C2781182431 @default.
• W4361948772 hasConceptScore W4361948772C44249647 @default.
• W4361948772 hasConceptScore W4361948772C71924100 @default.
• W4361948772 hasLocation W43619487721 @default.
• W4361948772 hasLocation W43619487722 @default.
• W4361948772 hasOpenAccess W4361948772 @default.
• W4361948772 hasPrimaryLocation W43619487721 @default.
• W4361948772 hasRelatedWork W2057357849 @default.
• W4361948772 hasRelatedWork W2080671488 @default.
• W4361948772 hasRelatedWork W2114624491 @default.
• W4361948772 hasRelatedWork W2141593700 @default.
• W4361948772 hasRelatedWork W2378830451 @default.
• W4361948772 hasRelatedWork W2767281924 @default.
• W4361948772 hasRelatedWork W3137453696 @default.
• W4361948772 hasRelatedWork W4249139583 @default.
• W4361948772 hasRelatedWork W4285493377 @default.
• W4361948772 hasRelatedWork W4307034070 @default.
• W4361948772 isParatext "false" @default.
• W4361948772 isRetracted "false" @default.
• W4361948772 workType "article" @default.