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• W4361948912 abstract "<div>Abstract<p><b>Purpose:</b> The <i>HOX</i> genes comprise a large family of homeodomain-containing transcription factors, present in four separate clusters, which are key regulators of embryonic development, hematopoietic differentiation, and leukemogenesis. We aimed to study the role of DNA methylation as an inducer of <i>HOX</i> gene silencing in leukemia.</p><p><b>Experimental Design:</b> Three hundred and seventy-eight samples of myeloid and lymphoid leukemia were quantitatively analyzed (by COBRA analysis and pyrosequencing of bisulfite-modified DNA) for methylation of eight <i>HOXA</i> and <i>HOXB</i> cluster genes. The biological significance of the methylation identified was studied by expression analysis and through re-expression of <i>HOXA5</i> in a chronic myeloid leukemia (CML) blast crisis cell line model.</p><p><b>Results:</b> Here, we identify frequent hypermethylation and gene inactivation of <i>HOXA</i> and <i>HOXB</i> cluster genes in leukemia. In particular, hypermethylation of <i>HOXA4</i> and <i>HOXA5</i> was frequently observed (26-79%) in all types of leukemias studied. <i>HOXA6</i> hypermethylation was predominantly restricted to lymphoid malignancies, whereas hypermethylation of other <i>HOXA</i> and <i>HOXB</i> genes was only observed in childhood leukemia. <i>HOX</i> gene methylation exhibited clear correlations with important clinical variables, most notably in CML, in which hypermethylation of both <i>HOXA5</i> (<i>P</i> = 0.00002) and <i>HOXA4</i> (<i>P</i> = 0.006) was strongly correlated with progression to blast crisis. Furthermore, re-expression of HOXA5 in CML blast crisis cells resulted in the induction of markers of granulocytic differentiation.</p><p><b>Conclusion:</b> We propose that in addition to the oncogenic role of some HOX family members, other <i>HOX</i> genes are frequent targets for gene inactivation and normally play suppressor roles in leukemia development.</p></div>" @default.
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• W4361948912 date "2023-03-31" @default.
• W4361948912 modified "2023-09-26" @default.
• W4361948912 title "Data from Inactivation of <i>HOXA</i> Genes by Hypermethylation in Myeloid and Lymphoid Malignancy is Frequent and Associated with Poor Prognosis" @default.
• W4361948912 doi "https://doi.org/10.1158/1078-0432.c.6517411.v1" @default.
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