Matches in SemOpenAlex for { <https://semopenalex.org/work/W4361948921> ?p ?o ?g. }
Showing items 1 to 68 of
68
with 100 items per page.
- W4361948921 abstract "<div>Abstract<p><b>Purpose:</b> Most node-negative breast cancer patients are older and postmenopausal and are increasingly being offered adjuvant chemotherapy despite their low overall risk of distant relapse. A molecular diagnostic test with high negative predictive value (NPV) for distant metastasis in this subgroup would spare many older breast cancer patients adjuvant treatment.</p><p><b>Experimental Design:</b> We determined the NPV and positive predictive value of the MammaPrint assay in breast cancer patients who were consecutively diagnosed and treated at the Massachusetts General Hospital between 1985 and 1997. Primary tumors from 100 patients with node-negative, invasive breast cancer (median age, 62.5 years; median follow-up, 11.3 years) were subjected to MammaPrint analysis and classified as being at either low or high risk for distant metastasis.</p><p><b>Results:</b> The MammaPrint 70-gene signature displayed excellent NPV as in previous studies, correctly identifying 100% of women at low risk for distant metastases at 5 years. However, this assay had a lower positive predictive value (12% at 5 years) than previously observed.</p><p><b>Conclusions:</b> The MammaPrint assay was originally designed to identify younger breast cancer patients at low risk for distant metastasis, who might consequently be spared systemic treatment. We show here that the same signature has a very high NPV for distant recurrence after adjuvant treatment in older breast cancer patients.</p></div>" @default.
- W4361948921 created "2023-04-05" @default.
- W4361948921 creator A5000563525 @default.
- W4361948921 creator A5001612937 @default.
- W4361948921 creator A5009616281 @default.
- W4361948921 creator A5013104624 @default.
- W4361948921 creator A5018693359 @default.
- W4361948921 creator A5028266055 @default.
- W4361948921 creator A5032742387 @default.
- W4361948921 creator A5034256147 @default.
- W4361948921 creator A5034418316 @default.
- W4361948921 creator A5055013846 @default.
- W4361948921 creator A5066599334 @default.
- W4361948921 creator A5040937972 @default.
- W4361948921 date "2023-03-31" @default.
- W4361948921 modified "2023-10-18" @default.
- W4361948921 title "Data from Analysis of the MammaPrint Breast Cancer Assay in a Predominantly Postmenopausal Cohort" @default.
- W4361948921 doi "https://doi.org/10.1158/1078-0432.c.6516784.v1" @default.
- W4361948921 hasPublicationYear "2023" @default.
- W4361948921 type Work @default.
- W4361948921 citedByCount "0" @default.
- W4361948921 crossrefType "posted-content" @default.
- W4361948921 hasAuthorship W4361948921A5000563525 @default.
- W4361948921 hasAuthorship W4361948921A5001612937 @default.
- W4361948921 hasAuthorship W4361948921A5009616281 @default.
- W4361948921 hasAuthorship W4361948921A5013104624 @default.
- W4361948921 hasAuthorship W4361948921A5018693359 @default.
- W4361948921 hasAuthorship W4361948921A5028266055 @default.
- W4361948921 hasAuthorship W4361948921A5032742387 @default.
- W4361948921 hasAuthorship W4361948921A5034256147 @default.
- W4361948921 hasAuthorship W4361948921A5034418316 @default.
- W4361948921 hasAuthorship W4361948921A5040937972 @default.
- W4361948921 hasAuthorship W4361948921A5055013846 @default.
- W4361948921 hasAuthorship W4361948921A5066599334 @default.
- W4361948921 hasBestOaLocation W43619489212 @default.
- W4361948921 hasConcept C121608353 @default.
- W4361948921 hasConcept C126322002 @default.
- W4361948921 hasConcept C143998085 @default.
- W4361948921 hasConcept C2779013556 @default.
- W4361948921 hasConcept C29456083 @default.
- W4361948921 hasConcept C3019926457 @default.
- W4361948921 hasConcept C530470458 @default.
- W4361948921 hasConcept C71924100 @default.
- W4361948921 hasConceptScore W4361948921C121608353 @default.
- W4361948921 hasConceptScore W4361948921C126322002 @default.
- W4361948921 hasConceptScore W4361948921C143998085 @default.
- W4361948921 hasConceptScore W4361948921C2779013556 @default.
- W4361948921 hasConceptScore W4361948921C29456083 @default.
- W4361948921 hasConceptScore W4361948921C3019926457 @default.
- W4361948921 hasConceptScore W4361948921C530470458 @default.
- W4361948921 hasConceptScore W4361948921C71924100 @default.
- W4361948921 hasLocation W43619489211 @default.
- W4361948921 hasLocation W43619489212 @default.
- W4361948921 hasOpenAccess W4361948921 @default.
- W4361948921 hasPrimaryLocation W43619489211 @default.
- W4361948921 hasRelatedWork W1967894062 @default.
- W4361948921 hasRelatedWork W2224319365 @default.
- W4361948921 hasRelatedWork W2332980943 @default.
- W4361948921 hasRelatedWork W2475667573 @default.
- W4361948921 hasRelatedWork W2502428149 @default.
- W4361948921 hasRelatedWork W3033874287 @default.
- W4361948921 hasRelatedWork W3088410393 @default.
- W4361948921 hasRelatedWork W3114415956 @default.
- W4361948921 hasRelatedWork W3160695097 @default.
- W4361948921 hasRelatedWork W377899687 @default.
- W4361948921 isParatext "false" @default.
- W4361948921 isRetracted "false" @default.
- W4361948921 workType "article" @default.