FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4361948935> ?p ?o ?g. }

• W4361948935 abstract "<div>Abstract<p><b>Purpose:</b> Inflammatory genes and microRNAs have roles in colon carcinogenesis; therefore, they may provide useful biomarkers for colon cancer. This study examines the potential clinical utility of an inflammatory gene expression signature as a prognostic biomarker for colon cancer in addition to previously examined <i>miR-21</i> expression.</p><p><b>Experimental Design:</b> Quantitative reverse transcriptase-PCR. was used to measure the expression of 23 inflammatory genes in colon adenocarcinomas and adjacent noncancerous tissues from 196 patients. These data were used to develop models for cancer-specific mortality on a training cohort (<i>n</i> = 57), and this model was tested in both a test (<i>n</i> = 56) and a validation (<i>n</i> = 83) cohort. Expression data for <i>miR-21</i> were available for these patients and were compared and combined with inflammatory gene expression.</p><p><b>Results:</b> <i>PRG1, IL-10, CD68, IL-23a</i>, and <i>IL-12a</i> expression in noncancerous tissue, and <i>PRG1, ANXA1, IL-23a, IL-17a, FOXP3</i>, and <i>HLA-DRA</i> expression in tumor tissues were associated with poor prognosis based on Cox regression (|Z-score| >1.5) and were used to generate the inflammatory risk score (IRS). IRS was associated with cancer-specific mortality in the training, test (<i>P</i> = 0.01), and validation (<i>P</i> = 0.02) cohorts. This association was strong for stage II cases (<i>P</i> = 0.002). Expression of <i>miR-21</i> was associated with <i>IL-6, IL-8, IL-10, IL-12a</i>, and <i>NOS2a</i>, providing evidence that the function of this microRNA and these inflammatory genes are linked. Both IRS and <i>miR-21</i> expression were independently associated with cancer-specific mortality, including stage II patients alone.</p><p><b>Conclusion:</b> IRS and <i>miR-21</i> expression are independent predictors of colon cancer prognosis and may provide a clinically useful tool to identify high-risk patients. (Clin Cancer Res 2009;15(18):5878–87)</p></div>" @default.
• W4361948935 created "2023-04-05" @default.
• W4361948935 creator A5027879594 @default.
• W4361948935 creator A5034572359 @default.
• W4361948935 creator A5050126669 @default.
• W4361948935 creator A5051353435 @default.
• W4361948935 creator A5065344066 @default.
• W4361948935 creator A5068591122 @default.
• W4361948935 creator A5079700663 @default.
• W4361948935 creator A5083687806 @default.
• W4361948935 creator A5091148741 @default.
• W4361948935 date "2023-03-31" @default.
• W4361948935 modified "2023-09-23" @default.
• W4361948935 title "Data from Association of Inflammation-Related and microRNA Gene Expression with Cancer-Specific Mortality of Colon Adenocarcinoma" @default.
• W4361948935 doi "https://doi.org/10.1158/1078-0432.c.6517660.v1" @default.
• W4361948935 hasPublicationYear "2023" @default.
• W4361948935 type Work @default.
• W4361948935 citedByCount "0" @default.
• W4361948935 crossrefType "posted-content" @default.
• W4361948935 hasAuthorship W4361948935A5027879594 @default.
• W4361948935 hasAuthorship W4361948935A5034572359 @default.
• W4361948935 hasAuthorship W4361948935A5050126669 @default.
• W4361948935 hasAuthorship W4361948935A5051353435 @default.
• W4361948935 hasAuthorship W4361948935A5065344066 @default.
• W4361948935 hasAuthorship W4361948935A5068591122 @default.
• W4361948935 hasAuthorship W4361948935A5079700663 @default.
• W4361948935 hasAuthorship W4361948935A5083687806 @default.
• W4361948935 hasAuthorship W4361948935A5091148741 @default.
• W4361948935 hasConcept C104317684 @default.
• W4361948935 hasConcept C121608353 @default.
• W4361948935 hasConcept C126322002 @default.
• W4361948935 hasConcept C143998085 @default.
• W4361948935 hasConcept C145059251 @default.
• W4361948935 hasConcept C150194340 @default.
• W4361948935 hasConcept C2776914184 @default.
• W4361948935 hasConcept C2781197716 @default.
• W4361948935 hasConcept C502942594 @default.
• W4361948935 hasConcept C526805850 @default.
• W4361948935 hasConcept C55493867 @default.
• W4361948935 hasConcept C71924100 @default.
• W4361948935 hasConcept C86803240 @default.
• W4361948935 hasConceptScore W4361948935C104317684 @default.
• W4361948935 hasConceptScore W4361948935C121608353 @default.
• W4361948935 hasConceptScore W4361948935C126322002 @default.
• W4361948935 hasConceptScore W4361948935C143998085 @default.
• W4361948935 hasConceptScore W4361948935C145059251 @default.
• W4361948935 hasConceptScore W4361948935C150194340 @default.
• W4361948935 hasConceptScore W4361948935C2776914184 @default.
• W4361948935 hasConceptScore W4361948935C2781197716 @default.
• W4361948935 hasConceptScore W4361948935C502942594 @default.
• W4361948935 hasConceptScore W4361948935C526805850 @default.
• W4361948935 hasConceptScore W4361948935C55493867 @default.
• W4361948935 hasConceptScore W4361948935C71924100 @default.
• W4361948935 hasConceptScore W4361948935C86803240 @default.
• W4361948935 hasLocation W43619489351 @default.
• W4361948935 hasOpenAccess W4361948935 @default.
• W4361948935 hasPrimaryLocation W43619489351 @default.
• W4361948935 hasRelatedWork W1965848638 @default.
• W4361948935 hasRelatedWork W2077423437 @default.
• W4361948935 hasRelatedWork W2128964826 @default.
• W4361948935 hasRelatedWork W2149920636 @default.
• W4361948935 hasRelatedWork W2348004935 @default.
• W4361948935 hasRelatedWork W2499610975 @default.
• W4361948935 hasRelatedWork W2963633392 @default.
• W4361948935 hasRelatedWork W2984941165 @default.
• W4361948935 hasRelatedWork W4361824450 @default.
• W4361948935 hasRelatedWork W4366985285 @default.
• W4361948935 isParatext "false" @default.
• W4361948935 isRetracted "false" @default.
• W4361948935 workType "article" @default.