Matches in SemOpenAlex for { <https://semopenalex.org/work/W4361948957> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- W4361948957 abstract "<div>AbstractPurpose:<p>Placental growth factor (PlGF) and its receptor neuropilin 1 are elevated in malignant embryonal tumors and mediate tumor progression by promoting cell proliferation, survival, and metastasis. TB-403 is a blocking monoclonal antibody against PlGF that inhibits tumor growth and increases survival in orthotopic medulloblastoma models.</p>Patients and Methods:<p>We conducted a phase I, open-label, multicenter, dose-escalation study of TB-403 in pediatric subjects with relapsed or refractory cancers. The study involved four dose levels (20 mg/kg, 50 mg/kg, 100 mg/kg, 175 mg/kg) using a 3 + 3 dose-escalation scheme. Subjects received two doses of TB-403 (days 1 and 15) per cycle. After cycle 1, temozolomide or etoposide could be added. The primary objective was to determine the maximum tolerated dose (MTD) of TB-403 monotherapy during a dose-limiting toxicity assessment period. The secondary and exploratory objectives included efficacy, drug pharmacokinetics, and detection of pharmacodynamic biomarkers.</p>Results:<p>Fifteen subjects were treated in four dose levels. All subjects received two doses of TB-403 in cycle 1. Five serious treatment-emergent adverse events were reported in 3 subjects, but MTD was not reached. While no complete nor partial responses were observed, 7 of 11 relapsed subjects with medulloblastoma experienced stable disease, which persisted for more than 100 days in 4 of 7 subjects.</p>Conclusions:<p>TB-403 was safe and well tolerated at all dose levels. No MTD was reached. The results look encouraging and therefore warrant further evaluation of efficacy in pediatric subjects with medulloblastoma.</p></div>" @default.
- W4361948957 created "2023-04-05" @default.
- W4361948957 creator A5000749732 @default.
- W4361948957 creator A5007530102 @default.
- W4361948957 creator A5008119029 @default.
- W4361948957 creator A5009693000 @default.
- W4361948957 creator A5015585176 @default.
- W4361948957 creator A5018365454 @default.
- W4361948957 creator A5022702941 @default.
- W4361948957 creator A5028526364 @default.
- W4361948957 creator A5032496658 @default.
- W4361948957 creator A5047152113 @default.
- W4361948957 creator A5050319286 @default.
- W4361948957 creator A5073819910 @default.
- W4361948957 creator A5078452073 @default.
- W4361948957 creator A5087551014 @default.
- W4361948957 creator A5087587424 @default.
- W4361948957 creator A5090169591 @default.
- W4361948957 date "2023-03-31" @default.
- W4361948957 modified "2023-10-18" @default.
- W4361948957 title "Data from A Phase I Trial of TB-403 in Relapsed Medulloblastoma, Neuroblastoma, Ewing Sarcoma, and Alveolar Rhabdomyosarcoma" @default.
- W4361948957 doi "https://doi.org/10.1158/1078-0432.c.6532608" @default.
- W4361948957 hasPublicationYear "2023" @default.
- W4361948957 type Work @default.
- W4361948957 citedByCount "0" @default.
- W4361948957 crossrefType "posted-content" @default.
- W4361948957 hasAuthorship W4361948957A5000749732 @default.
- W4361948957 hasAuthorship W4361948957A5007530102 @default.
- W4361948957 hasAuthorship W4361948957A5008119029 @default.
- W4361948957 hasAuthorship W4361948957A5009693000 @default.
- W4361948957 hasAuthorship W4361948957A5015585176 @default.
- W4361948957 hasAuthorship W4361948957A5018365454 @default.
- W4361948957 hasAuthorship W4361948957A5022702941 @default.
- W4361948957 hasAuthorship W4361948957A5028526364 @default.
- W4361948957 hasAuthorship W4361948957A5032496658 @default.
- W4361948957 hasAuthorship W4361948957A5047152113 @default.
- W4361948957 hasAuthorship W4361948957A5050319286 @default.
- W4361948957 hasAuthorship W4361948957A5073819910 @default.
- W4361948957 hasAuthorship W4361948957A5078452073 @default.
- W4361948957 hasAuthorship W4361948957A5087551014 @default.
- W4361948957 hasAuthorship W4361948957A5087587424 @default.
- W4361948957 hasAuthorship W4361948957A5090169591 @default.
- W4361948957 hasConcept C126322002 @default.
- W4361948957 hasConcept C142724271 @default.
- W4361948957 hasConcept C143998085 @default.
- W4361948957 hasConcept C2778256501 @default.
- W4361948957 hasConcept C2780789225 @default.
- W4361948957 hasConcept C2780844630 @default.
- W4361948957 hasConcept C71924100 @default.
- W4361948957 hasConcept C90924648 @default.
- W4361948957 hasConceptScore W4361948957C126322002 @default.
- W4361948957 hasConceptScore W4361948957C142724271 @default.
- W4361948957 hasConceptScore W4361948957C143998085 @default.
- W4361948957 hasConceptScore W4361948957C2778256501 @default.
- W4361948957 hasConceptScore W4361948957C2780789225 @default.
- W4361948957 hasConceptScore W4361948957C2780844630 @default.
- W4361948957 hasConceptScore W4361948957C71924100 @default.
- W4361948957 hasConceptScore W4361948957C90924648 @default.
- W4361948957 hasLocation W43619489571 @default.
- W4361948957 hasOpenAccess W4361948957 @default.
- W4361948957 hasPrimaryLocation W43619489571 @default.
- W4361948957 hasRelatedWork W1968221927 @default.
- W4361948957 hasRelatedWork W1982040265 @default.
- W4361948957 hasRelatedWork W1986439267 @default.
- W4361948957 hasRelatedWork W2096611181 @default.
- W4361948957 hasRelatedWork W2138805078 @default.
- W4361948957 hasRelatedWork W2184794669 @default.
- W4361948957 hasRelatedWork W2416359636 @default.
- W4361948957 hasRelatedWork W2590594752 @default.
- W4361948957 hasRelatedWork W279303386 @default.
- W4361948957 hasRelatedWork W74161940 @default.
- W4361948957 isParatext "false" @default.
- W4361948957 isRetracted "false" @default.
- W4361948957 workType "article" @default.