FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4361949162> ?p ?o ?g. }

• W4361949162 abstract "<div>Abstract<p><b>Purpose:</b> We investigated the antitumor effect of murine/human chimeric CD138-specific monoclonal antibody nBT062 conjugated with highly cytotoxic maytansinoid derivatives against multiple myeloma (MM) cells <i>in vitro</i> and <i>in vivo</i>.</p><p><b>Experimental Design:</b> We examined the growth inhibitory effect of BT062-SPDB-DM4, BT062-SMCC-DM1, and BT062-SPP-DM1 against MM cell lines and primary tumor cells from MM patients. We also examined <i>in vivo</i> activity of these agents in murine MM cell xenograft model of human and severe combined immunodeficient (SCID) mice bearing implant bone chips injected with human MM cells (SCID-hu model).</p><p><b>Results:</b> Anti-CD138 immunoconjugates significantly inhibited growth of MM cell lines and primary tumor cells from MM patients without cytotoxicity against peripheral blood mononuclear cells from healthy volunteers. In MM cells, they induced G₂-M cell cycle arrest, followed by apoptosis associated with cleavage of caspase-3, caspase-8, caspase-9, and poly(ADP-ribose) polymerase. Nonconjugated nBT062 completely blocked cytotoxicity induced by nBT062-maytansinoid conjugate, confirming that specific binding is required for inducing cytotoxicity. Moreover, nBT062-maytansinoid conjugates blocked adhesion of MM cells to bone marrow stromal cells. The coculture of MM cells with bone marrow stromal cells protects against dexamethasone-induced death but had no effect on the cytotoxicity of immunoconjugates. Importantly, nBT062-SPDB-DM4 and nBT062-SPP-DM1 significantly inhibited MM tumor growth <i>in vivo</i> and prolonged host survival in both the xenograft mouse models of human MM and SCID-hu mouse model.</p><p><b>Conclusion:</b> These results provide the preclinical framework supporting evaluation of nBT062-maytansinoid derivatives in clinical trials to improve patient outcome in MM.</p></div>" @default.
• W4361949162 created "2023-04-05" @default.
• W4361949162 creator A5005425076 @default.
• W4361949162 creator A5006954456 @default.
• W4361949162 creator A5016586425 @default.
• W4361949162 creator A5016860333 @default.
• W4361949162 creator A5019802024 @default.
• W4361949162 creator A5032464400 @default.
• W4361949162 creator A5036537233 @default.
• W4361949162 creator A5043526996 @default.
• W4361949162 creator A5045095062 @default.
• W4361949162 creator A5045740077 @default.
• W4361949162 creator A5052048627 @default.
• W4361949162 creator A5057460944 @default.
• W4361949162 creator A5061228788 @default.
• W4361949162 creator A5062468245 @default.
• W4361949162 creator A5067807477 @default.
• W4361949162 creator A5070359568 @default.
• W4361949162 creator A5078614658 @default.
• W4361949162 creator A5083655413 @default.
• W4361949162 creator A5084530923 @default.
• W4361949162 creator A5090686439 @default.
• W4361949162 creator A5091207345 @default.
• W4361949162 date "2023-03-31" @default.
• W4361949162 modified "2023-09-25" @default.
• W4361949162 title "Data from The Monoclonal Antibody nBT062 Conjugated to Cytotoxic Maytansinoids Has Selective Cytotoxicity Against CD138-Positive Multiple Myeloma Cells <i>In vitro</i> and <i>In vivo</i>" @default.
• W4361949162 doi "https://doi.org/10.1158/1078-0432.c.6517504.v1" @default.
• W4361949162 hasPublicationYear "2023" @default.
• W4361949162 type Work @default.
• W4361949162 citedByCount "0" @default.
• W4361949162 crossrefType "posted-content" @default.
• W4361949162 hasAuthorship W4361949162A5005425076 @default.
• W4361949162 hasAuthorship W4361949162A5006954456 @default.
• W4361949162 hasAuthorship W4361949162A5016586425 @default.
• W4361949162 hasAuthorship W4361949162A5016860333 @default.
• W4361949162 hasAuthorship W4361949162A5019802024 @default.
• W4361949162 hasAuthorship W4361949162A5032464400 @default.
• W4361949162 hasAuthorship W4361949162A5036537233 @default.
• W4361949162 hasAuthorship W4361949162A5043526996 @default.
• W4361949162 hasAuthorship W4361949162A5045095062 @default.
• W4361949162 hasAuthorship W4361949162A5045740077 @default.
• W4361949162 hasAuthorship W4361949162A5052048627 @default.
• W4361949162 hasAuthorship W4361949162A5057460944 @default.
• W4361949162 hasAuthorship W4361949162A5061228788 @default.
• W4361949162 hasAuthorship W4361949162A5062468245 @default.
• W4361949162 hasAuthorship W4361949162A5067807477 @default.
• W4361949162 hasAuthorship W4361949162A5070359568 @default.
• W4361949162 hasAuthorship W4361949162A5078614658 @default.
• W4361949162 hasAuthorship W4361949162A5083655413 @default.
• W4361949162 hasAuthorship W4361949162A5084530923 @default.
• W4361949162 hasAuthorship W4361949162A5090686439 @default.
• W4361949162 hasAuthorship W4361949162A5091207345 @default.
• W4361949162 hasBestOaLocation W43619491622 @default.
• W4361949162 hasConcept C109316439 @default.
• W4361949162 hasConcept C150903083 @default.
• W4361949162 hasConcept C153911025 @default.
• W4361949162 hasConcept C154317977 @default.
• W4361949162 hasConcept C16930146 @default.
• W4361949162 hasConcept C185592680 @default.
• W4361949162 hasConcept C190283241 @default.
• W4361949162 hasConcept C202751555 @default.
• W4361949162 hasConcept C203014093 @default.
• W4361949162 hasConcept C207001950 @default.
• W4361949162 hasConcept C2780007613 @default.
• W4361949162 hasConcept C502942594 @default.
• W4361949162 hasConcept C55493867 @default.
• W4361949162 hasConcept C86803240 @default.
• W4361949162 hasConceptScore W4361949162C109316439 @default.
• W4361949162 hasConceptScore W4361949162C150903083 @default.
• W4361949162 hasConceptScore W4361949162C153911025 @default.
• W4361949162 hasConceptScore W4361949162C154317977 @default.
• W4361949162 hasConceptScore W4361949162C16930146 @default.
• W4361949162 hasConceptScore W4361949162C185592680 @default.
• W4361949162 hasConceptScore W4361949162C190283241 @default.
• W4361949162 hasConceptScore W4361949162C202751555 @default.
• W4361949162 hasConceptScore W4361949162C203014093 @default.
• W4361949162 hasConceptScore W4361949162C207001950 @default.
• W4361949162 hasConceptScore W4361949162C2780007613 @default.
• W4361949162 hasConceptScore W4361949162C502942594 @default.
• W4361949162 hasConceptScore W4361949162C55493867 @default.
• W4361949162 hasConceptScore W4361949162C86803240 @default.
• W4361949162 hasLocation W43619491621 @default.
• W4361949162 hasLocation W43619491622 @default.
• W4361949162 hasOpenAccess W4361949162 @default.
• W4361949162 hasPrimaryLocation W43619491621 @default.
• W4361949162 hasRelatedWork W1592261125 @default.
• W4361949162 hasRelatedWork W1982027601 @default.
• W4361949162 hasRelatedWork W1990434843 @default.
• W4361949162 hasRelatedWork W200909032 @default.
• W4361949162 hasRelatedWork W2013842389 @default.
• W4361949162 hasRelatedWork W2071664329 @default.
• W4361949162 hasRelatedWork W2119737712 @default.
• W4361949162 hasRelatedWork W2187248412 @default.
• W4361949162 hasRelatedWork W2464301138 @default.
• W4361949162 hasRelatedWork W2517050254 @default.
• W4361949162 isParatext "false" @default.
• W4361949162 isRetracted "false" @default.
• W4361949162 workType "article" @default.