Matches in SemOpenAlex for { <https://semopenalex.org/work/W4361949216> ?p ?o ?g. }
Showing items 1 to 68 of
68
with 100 items per page.
- W4361949216 abstract "<div>Abstract<p><b>Purpose:</b> Nonmelanoma skin cancer incidence is enhanced >50-fold in patients taking antirejection drugs (ARD) following organ transplantation. Preclinical studies suggest that ARD treatment increases transforming growth factor-β1 (TGF-β1) levels, which contribute to enhanced tumor susceptibility independent of the immunosuppressive effects of ARDs. This study investigates whether TGF-β signaling is elevated in transplant patients.</p><p><b>Experimental Design:</b> Immunohistochemical tissue microarray analysis was used to determine the levels of TGF-β1, TGF-β2, TGF-β3, TβRII, and activated P-Smad2/3 and P-Smad1/5/8, which are phosphorylated directly by distinct TGF-β/BMP receptor complexes. We analyzed >200 cutaneous lesions and adjacent nonlesional skin samples from 87 organ transplant recipients, and 184 cutaneous lesions and adjacent skin samples from 184 individuals who had never received ARDs.</p><p><b>Results:</b> We found significantly higher levels of P-Smad2 in both nonlesional and lesional tissue from transplant recipients compared with those not exposed to ARDs (<i>P</i> ≤ 0.001). In contrast, P-Smad1/5/8, a marker of activation of the bone morphogenetic protein signaling pathway, was generally not expressed at higher levels in patients taking ARDs, including analysis of nonlesional skin, actinic keratoses, carcinoma <i>in situ</i>, or squamous cell carcinoma but was differentially expressed between keratoacanthoma from transplant recipients compared with those from non–transplant recipients (<i>P</i> ≤ 0.005).</p><p><b>Conclusions:</b> Observation of elevated P-Smad2 levels in transplant recipients is consistent with the notion that elevated TGF-β signaling may contribute to malignancy in organ transplant recipients. Disparate P-Smad1/5/8 expression levels between keratoacanthoma from the two patient groups might reflect the distinct BMP-responsive cell of origin for this hair follicle–derived lesion. (Clin Cancer Res 2009;15(16):5101–7)</p></div>" @default.
- W4361949216 created "2023-04-05" @default.
- W4361949216 creator A5016255484 @default.
- W4361949216 creator A5031498143 @default.
- W4361949216 creator A5031964615 @default.
- W4361949216 creator A5033526461 @default.
- W4361949216 creator A5059427266 @default.
- W4361949216 creator A5059617881 @default.
- W4361949216 creator A5062535075 @default.
- W4361949216 creator A5073440429 @default.
- W4361949216 creator A5076488025 @default.
- W4361949216 date "2023-03-31" @default.
- W4361949216 modified "2023-10-14" @default.
- W4361949216 title "Data from Elevated Cutaneous Smad Activation Associates with Enhanced Skin Tumor Susceptibility in Organ Transplant Recipients" @default.
- W4361949216 doi "https://doi.org/10.1158/1078-0432.c.6517639.v1" @default.
- W4361949216 hasPublicationYear "2023" @default.
- W4361949216 type Work @default.
- W4361949216 citedByCount "0" @default.
- W4361949216 crossrefType "posted-content" @default.
- W4361949216 hasAuthorship W4361949216A5016255484 @default.
- W4361949216 hasAuthorship W4361949216A5031498143 @default.
- W4361949216 hasAuthorship W4361949216A5031964615 @default.
- W4361949216 hasAuthorship W4361949216A5033526461 @default.
- W4361949216 hasAuthorship W4361949216A5059427266 @default.
- W4361949216 hasAuthorship W4361949216A5059617881 @default.
- W4361949216 hasAuthorship W4361949216A5062535075 @default.
- W4361949216 hasAuthorship W4361949216A5073440429 @default.
- W4361949216 hasAuthorship W4361949216A5076488025 @default.
- W4361949216 hasBestOaLocation W43619492162 @default.
- W4361949216 hasConcept C118131993 @default.
- W4361949216 hasConcept C121608353 @default.
- W4361949216 hasConcept C126322002 @default.
- W4361949216 hasConcept C142724271 @default.
- W4361949216 hasConcept C168444539 @default.
- W4361949216 hasConcept C204232928 @default.
- W4361949216 hasConcept C2777789703 @default.
- W4361949216 hasConcept C2781080636 @default.
- W4361949216 hasConcept C2911091166 @default.
- W4361949216 hasConcept C502942594 @default.
- W4361949216 hasConcept C71924100 @default.
- W4361949216 hasConceptScore W4361949216C118131993 @default.
- W4361949216 hasConceptScore W4361949216C121608353 @default.
- W4361949216 hasConceptScore W4361949216C126322002 @default.
- W4361949216 hasConceptScore W4361949216C142724271 @default.
- W4361949216 hasConceptScore W4361949216C168444539 @default.
- W4361949216 hasConceptScore W4361949216C204232928 @default.
- W4361949216 hasConceptScore W4361949216C2777789703 @default.
- W4361949216 hasConceptScore W4361949216C2781080636 @default.
- W4361949216 hasConceptScore W4361949216C2911091166 @default.
- W4361949216 hasConceptScore W4361949216C502942594 @default.
- W4361949216 hasConceptScore W4361949216C71924100 @default.
- W4361949216 hasLocation W43619492161 @default.
- W4361949216 hasLocation W43619492162 @default.
- W4361949216 hasOpenAccess W4361949216 @default.
- W4361949216 hasPrimaryLocation W43619492161 @default.
- W4361949216 hasRelatedWork W1542478579 @default.
- W4361949216 hasRelatedWork W1916113521 @default.
- W4361949216 hasRelatedWork W2163335237 @default.
- W4361949216 hasRelatedWork W2390403521 @default.
- W4361949216 hasRelatedWork W2462200495 @default.
- W4361949216 hasRelatedWork W2512546320 @default.
- W4361949216 hasRelatedWork W2520976589 @default.
- W4361949216 hasRelatedWork W2596432151 @default.
- W4361949216 hasRelatedWork W3113203979 @default.
- W4361949216 hasRelatedWork W2480856714 @default.
- W4361949216 isParatext "false" @default.
- W4361949216 isRetracted "false" @default.
- W4361949216 workType "article" @default.