FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4361951037> ?p ?o ?g. }

• W4361951037 abstract "<div>Abstract<p><b>Purpose:</b> This study was conducted to explore the differences in salivary microRNA (miRNA) profiles between patients with malignant or benign parotid gland tumors as a potential preoperative diagnostic tool of tumors in the salivary glands.</p><p><b>Experimental Design:</b> Whole saliva samples from patients with malignant (<i>n</i> = 38) or benign (<i>n</i> = 29) parotid gland tumors were obtained from the Salivary Gland Tumor Biorepository (SGTB). After total RNA isolation, human miRNA cards were used for miRNA profiling. The differential miRNA expression was analyzed using two-sided Wilcoxon test. Quantitative real-time PCR (qRT-PCR) was used to validate selected miRNAs in an independent sample set. Receiver-operating characteristics curve and probability of malignancy was exploited to evaluate the diagnostic power of the validated miRNAs.</p><p><b>Results:</b> With miRNA profiling, 57 of 750 investigated miRNAs were differently expressed, of which 54 showed higher miRNA expression in samples from patients with malignant tumors than those from patients with benign tumors. Validating the expression in an independent sample set of 9 miRNAs revealed indeed higher expression of miRNAs in malignant samples compared with benign samples. The expression of 6 validated miRNAs was statistically significantly different between the two groups (<i>P</i> < 0.05). A four miRNA combination was able to discriminate between saliva samples from patients with malignant tumors from those of patients with benign parotid gland tumors (sensitivity 69%, specificity 95%).</p><p><b>Conclusions:</b> Salivary miRNA profiles differ in saliva from patients with malignant from saliva from patients with a benign parotid gland tumor. These preliminary results are promising to develop a noninvasive diagnostic tool for diagnosing tumors in the salivary glands. <i>Clin Cancer Res; 19(11); 3032–8. ©2013 AACR</i>.</p></div>" @default.
• W4361951037 created "2023-04-05" @default.
• W4361951037 creator A5028568357 @default.
• W4361951037 creator A5036292170 @default.
• W4361951037 creator A5038085558 @default.
• W4361951037 creator A5039832836 @default.
• W4361951037 creator A5050763405 @default.
• W4361951037 creator A5066779494 @default.
• W4361951037 creator A5070990818 @default.
• W4361951037 creator A5087543035 @default.
• W4361951037 date "2023-03-31" @default.
• W4361951037 modified "2023-09-26" @default.
• W4361951037 title "Data from Discovery and Prevalidation of Salivary Extracellular microRNA Biomarkers Panel for the Noninvasive Detection of Benign and Malignant Parotid Gland Tumors" @default.
• W4361951037 doi "https://doi.org/10.1158/1078-0432.c.6522213.v1" @default.
• W4361951037 hasPublicationYear "2023" @default.
• W4361951037 type Work @default.
• W4361951037 citedByCount "0" @default.
• W4361951037 crossrefType "posted-content" @default.
• W4361951037 hasAuthorship W4361951037A5028568357 @default.
• W4361951037 hasAuthorship W4361951037A5036292170 @default.
• W4361951037 hasAuthorship W4361951037A5038085558 @default.
• W4361951037 hasAuthorship W4361951037A5039832836 @default.
• W4361951037 hasAuthorship W4361951037A5050763405 @default.
• W4361951037 hasAuthorship W4361951037A5066779494 @default.
• W4361951037 hasAuthorship W4361951037A5070990818 @default.
• W4361951037 hasAuthorship W4361951037A5087543035 @default.
• W4361951037 hasConcept C104317684 @default.
• W4361951037 hasConcept C126322002 @default.
• W4361951037 hasConcept C142724271 @default.
• W4361951037 hasConcept C145059251 @default.
• W4361951037 hasConcept C2778937882 @default.
• W4361951037 hasConcept C2779399171 @default.
• W4361951037 hasConcept C2780395140 @default.
• W4361951037 hasConcept C502942594 @default.
• W4361951037 hasConcept C504460877 @default.
• W4361951037 hasConcept C55493867 @default.
• W4361951037 hasConcept C71924100 @default.
• W4361951037 hasConcept C86803240 @default.
• W4361951037 hasConceptScore W4361951037C104317684 @default.
• W4361951037 hasConceptScore W4361951037C126322002 @default.
• W4361951037 hasConceptScore W4361951037C142724271 @default.
• W4361951037 hasConceptScore W4361951037C145059251 @default.
• W4361951037 hasConceptScore W4361951037C2778937882 @default.
• W4361951037 hasConceptScore W4361951037C2779399171 @default.
• W4361951037 hasConceptScore W4361951037C2780395140 @default.
• W4361951037 hasConceptScore W4361951037C502942594 @default.
• W4361951037 hasConceptScore W4361951037C504460877 @default.
• W4361951037 hasConceptScore W4361951037C55493867 @default.
• W4361951037 hasConceptScore W4361951037C71924100 @default.
• W4361951037 hasConceptScore W4361951037C86803240 @default.
• W4361951037 hasLocation W43619510371 @default.
• W4361951037 hasOpenAccess W4361951037 @default.
• W4361951037 hasPrimaryLocation W43619510371 @default.
• W4361951037 hasRelatedWork W1541277818 @default.
• W4361951037 hasRelatedWork W1868261495 @default.
• W4361951037 hasRelatedWork W2095302008 @default.
• W4361951037 hasRelatedWork W2227049856 @default.
• W4361951037 hasRelatedWork W2336168361 @default.
• W4361951037 hasRelatedWork W2508583876 @default.
• W4361951037 hasRelatedWork W2775634835 @default.
• W4361951037 hasRelatedWork W2965957431 @default.
• W4361951037 hasRelatedWork W4288062269 @default.
• W4361951037 hasRelatedWork W4312056419 @default.
• W4361951037 isParatext "false" @default.
• W4361951037 isRetracted "false" @default.
• W4361951037 workType "article" @default.