FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4361951569> ?p ?o ?g. }

• W4361951569 abstract "<div>Abstract<p><b>Purpose:</b> To evaluate whether tumor androgen receptor (AR) expression was prognostic and/or predictive for endocrine treatment alone or in combination with estrogen receptor (ER). The AR has been hypothesized to have differential prognostic roles in breast cancer depending on tumor ER status, and to influence endocrine treatment response.</p><p><b>Experimental Design:</b> A population-based prospective cohort of 1,026 patients diagnosed with primary invasive breast cancer in Lund, Sweden, between 2002 and 2012 was followed until June 2014. Associations between immunohistochemical AR expression in tumor tissue microarrays, patient and tumor characteristics, and AR genotypes were analyzed. Disease-free survival (DFS) by AR status, and combined ER/AR status was assessed in various treatment groups.</p><p><b>Results:</b> AR expression was assessable in 913 tumors. AR⁺ tumors (85.0%) were associated with higher age (<i>P</i> = 0.036) and favorable tumor characteristics. The AR⁺ status was a prognostic marker for DFS (LogRank <i>P</i> = 0.025). There was an interaction between AR and ER expression with respect to prognosis (adjusted <i>P</i>_interaction ≤ 0.024). Tumors with discordant hormone receptor expressions (ER⁺AR⁻ or ER⁻AR⁺) demonstrated worse prognosis compared with concordant tumor expressions (ER⁺AR⁺ or ER⁻AR⁻) in multivariable models [adjusted HRs (95% confidence intervals); ≥1.99 (1.28–3.10), <i>P</i> ≤ 0.002]. ER⁺AR⁻ indicated early treatment failure with aromatase inhibitors (AI) among chemonaïve patients aged 50 or older.</p><p><b>Conclusions:</b> Prediction of breast cancer prognosis and treatment response was improved by combining AR and ER status. AR negativity predicted early treatment failure with AI but not tamoxifen, a finding that warrants confirmation in a randomized setting. Patients may benefit from anti-androgens or selective AR modulators. <i>Clin Cancer Res; 21(16); 3640–50. ©2015 AACR</i>.</p></div>" @default.
• W4361951569 created "2023-04-05" @default.
• W4361951569 creator A5007633568 @default.
• W4361951569 creator A5023540175 @default.
• W4361951569 creator A5027449085 @default.
• W4361951569 creator A5029764881 @default.
• W4361951569 creator A5043291518 @default.
• W4361951569 creator A5048716668 @default.
• W4361951569 creator A5076400896 @default.
• W4361951569 creator A5078296697 @default.
• W4361951569 date "2023-03-31" @default.
• W4361951569 modified "2023-10-18" @default.
• W4361951569 title "Data from Combined Androgen and Estrogen Receptor Status in Breast Cancer: Treatment Prediction and Prognosis in a Population-Based Prospective Cohort" @default.
• W4361951569 doi "https://doi.org/10.1158/1078-0432.c.6523754.v1" @default.
• W4361951569 hasPublicationYear "2023" @default.
• W4361951569 type Work @default.
• W4361951569 citedByCount "0" @default.
• W4361951569 crossrefType "posted-content" @default.
• W4361951569 hasAuthorship W4361951569A5007633568 @default.
• W4361951569 hasAuthorship W4361951569A5023540175 @default.
• W4361951569 hasAuthorship W4361951569A5027449085 @default.
• W4361951569 hasAuthorship W4361951569A5029764881 @default.
• W4361951569 hasAuthorship W4361951569A5043291518 @default.
• W4361951569 hasAuthorship W4361951569A5048716668 @default.
• W4361951569 hasAuthorship W4361951569A5076400896 @default.
• W4361951569 hasAuthorship W4361951569A5078296697 @default.
• W4361951569 hasBestOaLocation W43619515692 @default.
• W4361951569 hasConcept C121608353 @default.
• W4361951569 hasConcept C126322002 @default.
• W4361951569 hasConcept C134018914 @default.
• W4361951569 hasConcept C143998085 @default.
• W4361951569 hasConcept C188816634 @default.
• W4361951569 hasConcept C193270364 @default.
• W4361951569 hasConcept C2780192828 @default.
• W4361951569 hasConcept C2908647359 @default.
• W4361951569 hasConcept C530470458 @default.
• W4361951569 hasConcept C61367390 @default.
• W4361951569 hasConcept C71924100 @default.
• W4361951569 hasConcept C84606932 @default.
• W4361951569 hasConcept C99454951 @default.
• W4361951569 hasConceptScore W4361951569C121608353 @default.
• W4361951569 hasConceptScore W4361951569C126322002 @default.
• W4361951569 hasConceptScore W4361951569C134018914 @default.
• W4361951569 hasConceptScore W4361951569C143998085 @default.
• W4361951569 hasConceptScore W4361951569C188816634 @default.
• W4361951569 hasConceptScore W4361951569C193270364 @default.
• W4361951569 hasConceptScore W4361951569C2780192828 @default.
• W4361951569 hasConceptScore W4361951569C2908647359 @default.
• W4361951569 hasConceptScore W4361951569C530470458 @default.
• W4361951569 hasConceptScore W4361951569C61367390 @default.
• W4361951569 hasConceptScore W4361951569C71924100 @default.
• W4361951569 hasConceptScore W4361951569C84606932 @default.
• W4361951569 hasConceptScore W4361951569C99454951 @default.
• W4361951569 hasLocation W43619515691 @default.
• W4361951569 hasLocation W43619515692 @default.
• W4361951569 hasOpenAccess W4361951569 @default.
• W4361951569 hasPrimaryLocation W43619515691 @default.
• W4361951569 hasRelatedWork W2004261902 @default.
• W4361951569 hasRelatedWork W2007496778 @default.
• W4361951569 hasRelatedWork W2095249856 @default.
• W4361951569 hasRelatedWork W2097689924 @default.
• W4361951569 hasRelatedWork W2159711144 @default.
• W4361951569 hasRelatedWork W2480442252 @default.
• W4361951569 hasRelatedWork W2725964416 @default.
• W4361951569 hasRelatedWork W2799559537 @default.
• W4361951569 hasRelatedWork W2885695836 @default.
• W4361951569 hasRelatedWork W4239151826 @default.
• W4361951569 isParatext "false" @default.
• W4361951569 isRetracted "false" @default.
• W4361951569 workType "article" @default.