Matches in SemOpenAlex for { <https://semopenalex.org/work/W4361951626> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W4361951626 abstract "<div>Abstract<p><b>Purpose:</b> Accumulating evidence indicates that intratumor heterogeneity is prevalent in multiple myeloma and that a collection of multiple, genetically distinct subclones are present within the myeloma cell population. It is not clear whether the size of clonal myeloma populations harboring unique cytogenetic abnormalities carry any additional prognostic value.</p><p><b>Experimental Design:</b> We analyzed the prognostic impact of cytogenetic aberrations by fluorescence in situ hybridization at different cutoff values in a cohort of 333 patients with newly diagnosed myeloma and 92 patients with relapsed myeloma.</p><p><b>Results:</b> We found that nearly all IgH-related arrangements were observed in a large majority of the purified plasma cells; however, 13q deletion, 17p deletion, and 1q21 amplification appeared in different percentages within the malignant plasma cell population. Based on the size of subclones carrying these cytogenetic aberrations, the patients were divided into four groups: 0%–10%, 10.5%–20%, 20.5%–50%, and >50%. Receiver-operating characteristics analysis was applied to determine the optimal cutoff value with the greatest differential survival and showed that the most powerful clone sizes were 10% for 13q deletion, 50% for 17p deletion, and 20% for 1q21 gains, which provided the best possible cutoffs for predicting poor outcomes.</p><p><b>Conclusions:</b> Our study indicated that the impact of clone size on prognostic value varies between specific genetic abnormalities. Prognostic value was observed for even a subgroup of plasma cells harboring the cytogenetic aberration of 13q deletion and 1q21 gains; however, 17p deletion displayed the most powerful cutoff for predicting survival only if the predominant clones harbored the abnormality. <i>Clin Cancer Res; 21(9); 2148–56. ©2015 AACR</i>.</p></div>" @default.
- W4361951626 created "2023-04-05" @default.
- W4361951626 creator A5000632526 @default.
- W4361951626 creator A5002917649 @default.
- W4361951626 creator A5005476912 @default.
- W4361951626 creator A5008130258 @default.
- W4361951626 creator A5008198016 @default.
- W4361951626 creator A5014942240 @default.
- W4361951626 creator A5017214725 @default.
- W4361951626 creator A5017804632 @default.
- W4361951626 creator A5019802024 @default.
- W4361951626 creator A5019947073 @default.
- W4361951626 creator A5027278571 @default.
- W4361951626 creator A5030223228 @default.
- W4361951626 creator A5030715375 @default.
- W4361951626 creator A5032464400 @default.
- W4361951626 creator A5044433615 @default.
- W4361951626 creator A5044751148 @default.
- W4361951626 creator A5058927188 @default.
- W4361951626 creator A5060867127 @default.
- W4361951626 creator A5066546272 @default.
- W4361951626 creator A5069491797 @default.
- W4361951626 creator A5079842099 @default.
- W4361951626 creator A5081434113 @default.
- W4361951626 creator A5086214965 @default.
- W4361951626 creator A5091040593 @default.
- W4361951626 date "2023-03-31" @default.
- W4361951626 modified "2023-10-17" @default.
- W4361951626 title "Data from The Impact of Clone Size on the Prognostic Value of Chromosome Aberrations by Fluorescence <i>In Situ</i> Hybridization in Multiple Myeloma" @default.
- W4361951626 doi "https://doi.org/10.1158/1078-0432.c.6523808.v1" @default.
- W4361951626 hasPublicationYear "2023" @default.
- W4361951626 type Work @default.
- W4361951626 citedByCount "0" @default.
- W4361951626 crossrefType "posted-content" @default.
- W4361951626 hasAuthorship W4361951626A5000632526 @default.
- W4361951626 hasAuthorship W4361951626A5002917649 @default.
- W4361951626 hasAuthorship W4361951626A5005476912 @default.
- W4361951626 hasAuthorship W4361951626A5008130258 @default.
- W4361951626 hasAuthorship W4361951626A5008198016 @default.
- W4361951626 hasAuthorship W4361951626A5014942240 @default.
- W4361951626 hasAuthorship W4361951626A5017214725 @default.
- W4361951626 hasAuthorship W4361951626A5017804632 @default.
- W4361951626 hasAuthorship W4361951626A5019802024 @default.
- W4361951626 hasAuthorship W4361951626A5019947073 @default.
- W4361951626 hasAuthorship W4361951626A5027278571 @default.
- W4361951626 hasAuthorship W4361951626A5030223228 @default.
- W4361951626 hasAuthorship W4361951626A5030715375 @default.
- W4361951626 hasAuthorship W4361951626A5032464400 @default.
- W4361951626 hasAuthorship W4361951626A5044433615 @default.
- W4361951626 hasAuthorship W4361951626A5044751148 @default.
- W4361951626 hasAuthorship W4361951626A5058927188 @default.
- W4361951626 hasAuthorship W4361951626A5060867127 @default.
- W4361951626 hasAuthorship W4361951626A5066546272 @default.
- W4361951626 hasAuthorship W4361951626A5069491797 @default.
- W4361951626 hasAuthorship W4361951626A5079842099 @default.
- W4361951626 hasAuthorship W4361951626A5081434113 @default.
- W4361951626 hasAuthorship W4361951626A5086214965 @default.
- W4361951626 hasAuthorship W4361951626A5091040593 @default.
- W4361951626 hasConcept C104317684 @default.
- W4361951626 hasConcept C153911025 @default.
- W4361951626 hasConcept C203014093 @default.
- W4361951626 hasConcept C2776364478 @default.
- W4361951626 hasConcept C2777542201 @default.
- W4361951626 hasConcept C2908647359 @default.
- W4361951626 hasConcept C30481170 @default.
- W4361951626 hasConcept C54355233 @default.
- W4361951626 hasConcept C71924100 @default.
- W4361951626 hasConcept C81089528 @default.
- W4361951626 hasConcept C86803240 @default.
- W4361951626 hasConcept C99454951 @default.
- W4361951626 hasConceptScore W4361951626C104317684 @default.
- W4361951626 hasConceptScore W4361951626C153911025 @default.
- W4361951626 hasConceptScore W4361951626C203014093 @default.
- W4361951626 hasConceptScore W4361951626C2776364478 @default.
- W4361951626 hasConceptScore W4361951626C2777542201 @default.
- W4361951626 hasConceptScore W4361951626C2908647359 @default.
- W4361951626 hasConceptScore W4361951626C30481170 @default.
- W4361951626 hasConceptScore W4361951626C54355233 @default.
- W4361951626 hasConceptScore W4361951626C71924100 @default.
- W4361951626 hasConceptScore W4361951626C81089528 @default.
- W4361951626 hasConceptScore W4361951626C86803240 @default.
- W4361951626 hasConceptScore W4361951626C99454951 @default.
- W4361951626 hasLocation W43619516261 @default.
- W4361951626 hasOpenAccess W4361951626 @default.
- W4361951626 hasPrimaryLocation W43619516261 @default.
- W4361951626 hasRelatedWork W2009787400 @default.
- W4361951626 hasRelatedWork W2064011923 @default.
- W4361951626 hasRelatedWork W2076566836 @default.
- W4361951626 hasRelatedWork W2121081280 @default.
- W4361951626 hasRelatedWork W2132838873 @default.
- W4361951626 hasRelatedWork W2410410655 @default.
- W4361951626 hasRelatedWork W2509559102 @default.
- W4361951626 hasRelatedWork W4285799149 @default.
- W4361951626 hasRelatedWork W4361946013 @default.
- W4361951626 hasRelatedWork W4361951626 @default.
- W4361951626 isParatext "false" @default.
- W4361951626 isRetracted "false" @default.
- W4361951626 workType "article" @default.