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- W4361952014 abstract "<div>Abstract<p><b>Purpose:</b> Aspirin has recently been reported to reduce both the incidence and the risk of metastasis in colon cancer. However, there is no evidence at the cellular levels or in the animal models for such an effect of aspirin on cancer metastasis.</p><p><b>Experimental Design:</b> MTT assay, colony formation assay, and apoptosis assay were employed to analyze the effects of aspirin on the osteosarcoma cell viability <i>in vitro</i>. The NF-κB activity was measured by the NF-κB p65 luciferase reporter. Western blotting was used to analyze the proteins in cells. The migration and invasion abilities of osteosarcoma cells <i>in vitro</i> were measured by the Transwell assay. Xenograft-bearing mice were used to assess the roles of aspirin in both tumor growth and metastasis of osteosarcoma <i>in vivo</i> (<i>n</i> = 5–8 mice/group). An unpaired Student <i>t</i> test or ANOVA with the Bonferroni <i>post hoc</i> test were used for the statistical comparisons.</p><p><b>Results:</b> Aspirin reduced cell viability in a dose- and time-dependent manner in osteosarcoma cell lines, and aspirin synergistically sensitized osteosarcoma cells to cisplatin (DDP) <i>in vitro</i> and <i>in vivo</i> (<i>P</i> < 0.001). Moreover, aspirin markedly repressed the migration and invasion of osteosarcoma cells <i>in vitro</i> (<i>P</i> < 0.001), and dramatically diminished the occurrence of osteosarcoma xenograft metastases to the lungs <i>in vivo</i> (<i>P</i> < 0.001). Mechanistically, aspirin diminishes osteosarcoma migration, invasion, and metastasis through the NF-κB pathway.</p><p><b>Conclusions:</b> Aspirin suppresses both the growth and metastasis of osteosarcoma through the NF-κB pathway at the cellular level and in the animal models. <i>Clin Cancer Res; 21(23); 5349–59. ©2015 AACR</i>.</p></div>" @default.
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- W4361952014 date "2023-03-31" @default.
- W4361952014 modified "2023-10-18" @default.
- W4361952014 title "Data from Aspirin Suppresses the Growth and Metastasis of Osteosarcoma through the NF-κB Pathway" @default.
- W4361952014 doi "https://doi.org/10.1158/1078-0432.c.6524894.v1" @default.
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