Matches in SemOpenAlex for { <https://semopenalex.org/work/W4361952015> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W4361952015 abstract "<div>Abstract<p><b>Purpose:</b> Chemoresistance is the main cause of treatment failure in cancer and is associated with distant metastases and epithelial-to-mesenchymal transition (EMT). This study was aimed to explore the mechanism of metastases and EMT in chemoresistant gastric cancer.</p><p><b>Experimental Design:</b> A key molecular pathway was identified via gene profiling and a bioinformatic analysis in a chemoresistant gastric cancer model. The roles of FOXL2, HMGA2, and ITGA2 were validated via loss-of-function and gain-of-function experiments <i>in vitro</i> and in an orthotopic gastric cancer animal model. The regulation of FOXL2 by HMGA2 was explored via immunoprecipitation and luciferase reporter assays. The expression of these proteins in gastric cancer tissues was examined by IHC.</p><p><b>Results:</b> HMGA2 and FOXL2 directly regulated the metastasis and EMT of chemoresistant gastric cancer. The interaction between HMGA2 and pRb facilitated the transactivation of FOXL2 by E2F1, and ITGA2 was the downstream effector of the HMGA2–FOXL2 pathway. HMGA2, FOXL2, and ITGA2 were associated with the TNM classification and staging of gastric cancer and were increased in metastatic lymph nodes and distant metastases. Increased HMGA2, FOXL2, and ITGA2 levels were associated with reduced overall survival periods of patients with gastric cancer.</p><p><b>Conclusions:</b> This study demonstrated that the transactivation of FOXL2 driven by interactions between HMGA2 and pRb might exert critical effects on the metastases and EMT of chemoresistant gastric cancer. Blocking the HMGA2–FOXL2–ITGA2 pathway could serve as a new strategy for gastric cancer treatment. <i>Clin Cancer Res; 23(13); 3461–73. ©2017 AACR</i>.</p></div>" @default.
- W4361952015 created "2023-04-05" @default.
- W4361952015 creator A5008141914 @default.
- W4361952015 creator A5018159956 @default.
- W4361952015 creator A5031553447 @default.
- W4361952015 creator A5056755738 @default.
- W4361952015 creator A5058040690 @default.
- W4361952015 creator A5070812231 @default.
- W4361952015 creator A5078303906 @default.
- W4361952015 creator A5080177287 @default.
- W4361952015 creator A5083074324 @default.
- W4361952015 creator A5083110767 @default.
- W4361952015 creator A5086991187 @default.
- W4361952015 creator A5087900743 @default.
- W4361952015 date "2023-03-31" @default.
- W4361952015 modified "2023-10-16" @default.
- W4361952015 title "Data from HMGA2–FOXL2 Axis Regulates Metastases and Epithelial-to-Mesenchymal Transition of Chemoresistant Gastric Cancer" @default.
- W4361952015 doi "https://doi.org/10.1158/1078-0432.c.6525278.v1" @default.
- W4361952015 hasPublicationYear "2023" @default.
- W4361952015 type Work @default.
- W4361952015 citedByCount "0" @default.
- W4361952015 crossrefType "posted-content" @default.
- W4361952015 hasAuthorship W4361952015A5008141914 @default.
- W4361952015 hasAuthorship W4361952015A5018159956 @default.
- W4361952015 hasAuthorship W4361952015A5031553447 @default.
- W4361952015 hasAuthorship W4361952015A5056755738 @default.
- W4361952015 hasAuthorship W4361952015A5058040690 @default.
- W4361952015 hasAuthorship W4361952015A5070812231 @default.
- W4361952015 hasAuthorship W4361952015A5078303906 @default.
- W4361952015 hasAuthorship W4361952015A5080177287 @default.
- W4361952015 hasAuthorship W4361952015A5083074324 @default.
- W4361952015 hasAuthorship W4361952015A5083110767 @default.
- W4361952015 hasAuthorship W4361952015A5086991187 @default.
- W4361952015 hasAuthorship W4361952015A5087900743 @default.
- W4361952015 hasConcept C104317684 @default.
- W4361952015 hasConcept C121608353 @default.
- W4361952015 hasConcept C126322002 @default.
- W4361952015 hasConcept C1292079 @default.
- W4361952015 hasConcept C145059251 @default.
- W4361952015 hasConcept C185592680 @default.
- W4361952015 hasConcept C2529059 @default.
- W4361952015 hasConcept C2776694085 @default.
- W4361952015 hasConcept C2778239845 @default.
- W4361952015 hasConcept C2779013556 @default.
- W4361952015 hasConcept C502942594 @default.
- W4361952015 hasConcept C55493867 @default.
- W4361952015 hasConcept C71924100 @default.
- W4361952015 hasConcept C76419328 @default.
- W4361952015 hasConcept C86339819 @default.
- W4361952015 hasConceptScore W4361952015C104317684 @default.
- W4361952015 hasConceptScore W4361952015C121608353 @default.
- W4361952015 hasConceptScore W4361952015C126322002 @default.
- W4361952015 hasConceptScore W4361952015C1292079 @default.
- W4361952015 hasConceptScore W4361952015C145059251 @default.
- W4361952015 hasConceptScore W4361952015C185592680 @default.
- W4361952015 hasConceptScore W4361952015C2529059 @default.
- W4361952015 hasConceptScore W4361952015C2776694085 @default.
- W4361952015 hasConceptScore W4361952015C2778239845 @default.
- W4361952015 hasConceptScore W4361952015C2779013556 @default.
- W4361952015 hasConceptScore W4361952015C502942594 @default.
- W4361952015 hasConceptScore W4361952015C55493867 @default.
- W4361952015 hasConceptScore W4361952015C71924100 @default.
- W4361952015 hasConceptScore W4361952015C76419328 @default.
- W4361952015 hasConceptScore W4361952015C86339819 @default.
- W4361952015 hasLocation W43619520151 @default.
- W4361952015 hasOpenAccess W4361952015 @default.
- W4361952015 hasPrimaryLocation W43619520151 @default.
- W4361952015 hasRelatedWork W2045867270 @default.
- W4361952015 hasRelatedWork W2051400608 @default.
- W4361952015 hasRelatedWork W2154708791 @default.
- W4361952015 hasRelatedWork W2337105312 @default.
- W4361952015 hasRelatedWork W2520686520 @default.
- W4361952015 hasRelatedWork W2763237291 @default.
- W4361952015 hasRelatedWork W2908944997 @default.
- W4361952015 hasRelatedWork W2950873861 @default.
- W4361952015 hasRelatedWork W3022892502 @default.
- W4361952015 hasRelatedWork W4361261034 @default.
- W4361952015 isParatext "false" @default.
- W4361952015 isRetracted "false" @default.
- W4361952015 workType "article" @default.