FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4361952404> ?p ?o ?g. }

• W4361952404 abstract "<div>Abstract<p><b>Purpose:</b> Despite initial benefit from tyrosine kinase inhibitors (TKIs), patients with advanced non–small cell lung cancer (NSCLC) harboring <i>ALK</i> (ALK⁺) and <i>ROS1</i> (ROS1⁺) gene fusions ultimately progress. Here, we report on the potential resistance mechanisms in a series of patients with ALK⁺ and ROS1⁺ NSCLC progressing on different types and/or lines of <i>ROS1/ALK</i>–targeted therapy.</p><p><b>Experimental Design:</b> We used a combination of next-generation sequencing (NGS), multiplex mutation assay, direct DNA sequencing, RT-PCR, and FISH to identify fusion variants/partners and copy-number gain (CNG), kinase domain mutations (KDM), and copy-number variations (CNVs) in other cancer-related genes. We performed testing on 12 <i>ROS1⁺</i> and 43 <i>ALK⁺</i> patients.</p><p><b>Results:</b> One of 12 ROS1⁺ (8%) and 15 of 43 (35%) ALK<i>⁺</i> patients harbored KDM. In the ROS1⁺ cohort, we identified <i>KIT</i> and β-catenin mutations and HER2-mediated bypass signaling as non-ROS1–dominant resistance mechanisms. In the ALK⁺ cohort, we identified a novel <i>NRG1</i> gene fusion, a <i>RET</i> fusion, 2 <i>EGFR</i>, and 3 <i>KRAS</i> mutations, as well as mutations in <i>IDH1, RIT1, NOTCH</i>, and <i>NF1</i>. In addition, we identified CNV in multiple proto-oncogenes genes including <i>PDGFRA, KIT, KDR, GNAS, K/HRAS, RET, NTRK1, MAP2K1,</i> and others.</p><p><b>Conclusions:</b> We identified a putative TKI resistance mechanism in six of 12 (50%) ROS1<i>⁺</i> patients and 37 of 43 (86%) ALK⁺ patients. Our data suggest that a focus on KDMs will miss most resistance mechanisms; broader gene testing strategies and functional validation is warranted to devise new therapeutic strategies for drug resistance. <i>Clin Cancer Res; 24(14); 3334–47. ©2018 AACR</i>.</p></div>" @default.
• W4361952404 created "2023-04-05" @default.
• W4361952404 creator A5004389580 @default.
• W4361952404 creator A5017096115 @default.
• W4361952404 creator A5022348436 @default.
• W4361952404 creator A5032743378 @default.
• W4361952404 creator A5033362539 @default.
• W4361952404 creator A5034705456 @default.
• W4361952404 creator A5037575339 @default.
• W4361952404 creator A5044209225 @default.
• W4361952404 creator A5052885079 @default.
• W4361952404 creator A5054931755 @default.
• W4361952404 creator A5056661941 @default.
• W4361952404 creator A5071670695 @default.
• W4361952404 creator A5075361012 @default.
• W4361952404 creator A5082517668 @default.
• W4361952404 creator A5085730704 @default.
• W4361952404 creator A5090028463 @default.
• W4361952404 date "2023-03-31" @default.
• W4361952404 modified "2023-09-26" @default.
• W4361952404 title "Data from Resistance Mechanisms to Targeted Therapies in <i>ROS1</i>⁺ and <i>ALK</i>⁺ Non–small Cell Lung Cancer" @default.
• W4361952404 doi "https://doi.org/10.1158/1078-0432.c.6525788.v1" @default.
• W4361952404 hasPublicationYear "2023" @default.
• W4361952404 type Work @default.
• W4361952404 citedByCount "0" @default.
• W4361952404 crossrefType "posted-content" @default.
• W4361952404 hasAuthorship W4361952404A5004389580 @default.
• W4361952404 hasAuthorship W4361952404A5017096115 @default.
• W4361952404 hasAuthorship W4361952404A5022348436 @default.
• W4361952404 hasAuthorship W4361952404A5032743378 @default.
• W4361952404 hasAuthorship W4361952404A5033362539 @default.
• W4361952404 hasAuthorship W4361952404A5034705456 @default.
• W4361952404 hasAuthorship W4361952404A5037575339 @default.
• W4361952404 hasAuthorship W4361952404A5044209225 @default.
• W4361952404 hasAuthorship W4361952404A5052885079 @default.
• W4361952404 hasAuthorship W4361952404A5054931755 @default.
• W4361952404 hasAuthorship W4361952404A5056661941 @default.
• W4361952404 hasAuthorship W4361952404A5071670695 @default.
• W4361952404 hasAuthorship W4361952404A5075361012 @default.
• W4361952404 hasAuthorship W4361952404A5082517668 @default.
• W4361952404 hasAuthorship W4361952404A5085730704 @default.
• W4361952404 hasAuthorship W4361952404A5090028463 @default.
• W4361952404 hasBestOaLocation W43619524042 @default.
• W4361952404 hasConcept C121608353 @default.
• W4361952404 hasConcept C153911025 @default.
• W4361952404 hasConcept C2775999482 @default.
• W4361952404 hasConcept C2781182431 @default.
• W4361952404 hasConcept C54355233 @default.
• W4361952404 hasConcept C86803240 @default.
• W4361952404 hasConceptScore W4361952404C121608353 @default.
• W4361952404 hasConceptScore W4361952404C153911025 @default.
• W4361952404 hasConceptScore W4361952404C2775999482 @default.
• W4361952404 hasConceptScore W4361952404C2781182431 @default.
• W4361952404 hasConceptScore W4361952404C54355233 @default.
• W4361952404 hasConceptScore W4361952404C86803240 @default.
• W4361952404 hasLocation W43619524041 @default.
• W4361952404 hasLocation W43619524042 @default.
• W4361952404 hasOpenAccess W4361952404 @default.
• W4361952404 hasPrimaryLocation W43619524041 @default.
• W4361952404 hasRelatedWork W2052546787 @default.
• W4361952404 hasRelatedWork W2058644395 @default.
• W4361952404 hasRelatedWork W2611128304 @default.
• W4361952404 hasRelatedWork W2953666243 @default.
• W4361952404 hasRelatedWork W2954262323 @default.
• W4361952404 hasRelatedWork W2964989113 @default.
• W4361952404 hasRelatedWork W2972270404 @default.
• W4361952404 hasRelatedWork W3114502609 @default.
• W4361952404 hasRelatedWork W3203934256 @default.
• W4361952404 hasRelatedWork W4220833182 @default.
• W4361952404 isParatext "false" @default.
• W4361952404 isRetracted "false" @default.
• W4361952404 workType "article" @default.