Matches in SemOpenAlex for { <https://semopenalex.org/work/W4361954317> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W4361954317 abstract "<div>AbstractPurpose:<p>Intensification of androgen deprivation therapy (ADT) with either docetaxel or androgen receptor axis–targeted therapies (ARAT) are the current standard of care for patients with metastatic castration-sensitive prostate cancer (mCSPC). However, biomarkers guiding treatment selection are lacking. We hypothesized that ADT intensification with ARAT, but not with docetaxel, would be associated with improved outcomes in patients with <i>de novo</i> (dn)-mCSPC harboring <i>SPOP</i> mutations.</p>Experimental Design:<p>Patient-level data from a deidentified nationwide (U.S.-based) prostate cancer clinico-genomic database between January 2011 and December 2021 were extracted. Eligibility criteria: diagnosis of metastatic disease within 30 days of original prostate cancer diagnosis, genomic profiling of a tissue biopsy collected within 90 days of original diagnosis, and initiation of ARAT or docetaxel within 120 days of initial diagnosis. The log-rank test and Cox proportional hazards models were used to compare time to castration-resistant prostate cancer (TTCRPC) and overall survival (OS) for patients with and without <i>SPOP</i> mutations undergoing ADT intensification with ARAT or docetaxel.</p>Results:<p>In the ARAT cohort, presence of <i>SPOP</i> mutation compared with wild-type was associated with more favorable TTCRPC [not reached (NR) vs. 16.7 months; adjusted HR (aHR), 0.20; 95% confidence interval (CI), 0.06–0.63; <i>P</i> = 0.006] and OS (NR vs. 27.2 months; aHR, 0.19; 95% CI, 0.05–0.79; <i>P</i> = 0.022). In contrast, <i>SPOP</i> mutation status was not associated with TTCRPC or OS in docetaxel-treated cohort.</p>Conclusions:<p>In real-world settings, <i>SPOP</i> mutations were associated with improved outcomes to ADT plus ARAT (but not ADT plus docetaxel) in patients with dn-mCSPC. This may serve as a predictive biomarker to guide treatment selection for patients with mCSPC.</p></div>" @default.
- W4361954317 created "2023-04-05" @default.
- W4361954317 creator A5006238975 @default.
- W4361954317 creator A5018645768 @default.
- W4361954317 creator A5025819053 @default.
- W4361954317 creator A5027336186 @default.
- W4361954317 creator A5034103357 @default.
- W4361954317 creator A5044148216 @default.
- W4361954317 creator A5045665778 @default.
- W4361954317 creator A5047258840 @default.
- W4361954317 creator A5055269586 @default.
- W4361954317 creator A5062019987 @default.
- W4361954317 creator A5067857479 @default.
- W4361954317 creator A5081755908 @default.
- W4361954317 creator A5084304704 @default.
- W4361954317 creator A5088559019 @default.
- W4361954317 date "2023-04-01" @default.
- W4361954317 modified "2023-09-25" @default.
- W4361954317 title "Data from SPOP Mutations as a Predictive Biomarker for Androgen Receptor Axis–Targeted Therapy in <i>De Novo</i> Metastatic Castration-Sensitive Prostate Cancer" @default.
- W4361954317 doi "https://doi.org/10.1158/1078-0432.c.6532739.v1" @default.
- W4361954317 hasPublicationYear "2023" @default.
- W4361954317 type Work @default.
- W4361954317 citedByCount "0" @default.
- W4361954317 crossrefType "posted-content" @default.
- W4361954317 hasAuthorship W4361954317A5006238975 @default.
- W4361954317 hasAuthorship W4361954317A5018645768 @default.
- W4361954317 hasAuthorship W4361954317A5025819053 @default.
- W4361954317 hasAuthorship W4361954317A5027336186 @default.
- W4361954317 hasAuthorship W4361954317A5034103357 @default.
- W4361954317 hasAuthorship W4361954317A5044148216 @default.
- W4361954317 hasAuthorship W4361954317A5045665778 @default.
- W4361954317 hasAuthorship W4361954317A5047258840 @default.
- W4361954317 hasAuthorship W4361954317A5055269586 @default.
- W4361954317 hasAuthorship W4361954317A5062019987 @default.
- W4361954317 hasAuthorship W4361954317A5067857479 @default.
- W4361954317 hasAuthorship W4361954317A5081755908 @default.
- W4361954317 hasAuthorship W4361954317A5084304704 @default.
- W4361954317 hasAuthorship W4361954317A5088559019 @default.
- W4361954317 hasConcept C121608353 @default.
- W4361954317 hasConcept C126322002 @default.
- W4361954317 hasConcept C143998085 @default.
- W4361954317 hasConcept C2776235491 @default.
- W4361954317 hasConcept C2777899217 @default.
- W4361954317 hasConcept C2777911890 @default.
- W4361954317 hasConcept C2780192828 @default.
- W4361954317 hasConcept C2781190966 @default.
- W4361954317 hasConcept C61367390 @default.
- W4361954317 hasConcept C71315377 @default.
- W4361954317 hasConcept C71924100 @default.
- W4361954317 hasConceptScore W4361954317C121608353 @default.
- W4361954317 hasConceptScore W4361954317C126322002 @default.
- W4361954317 hasConceptScore W4361954317C143998085 @default.
- W4361954317 hasConceptScore W4361954317C2776235491 @default.
- W4361954317 hasConceptScore W4361954317C2777899217 @default.
- W4361954317 hasConceptScore W4361954317C2777911890 @default.
- W4361954317 hasConceptScore W4361954317C2780192828 @default.
- W4361954317 hasConceptScore W4361954317C2781190966 @default.
- W4361954317 hasConceptScore W4361954317C61367390 @default.
- W4361954317 hasConceptScore W4361954317C71315377 @default.
- W4361954317 hasConceptScore W4361954317C71924100 @default.
- W4361954317 hasLocation W43619543171 @default.
- W4361954317 hasOpenAccess W4361954317 @default.
- W4361954317 hasPrimaryLocation W43619543171 @default.
- W4361954317 hasRelatedWork W2140855177 @default.
- W4361954317 hasRelatedWork W2770702948 @default.
- W4361954317 hasRelatedWork W2776596564 @default.
- W4361954317 hasRelatedWork W3023947295 @default.
- W4361954317 hasRelatedWork W3089863507 @default.
- W4361954317 hasRelatedWork W3200282916 @default.
- W4361954317 hasRelatedWork W4226303148 @default.
- W4361954317 hasRelatedWork W4229076799 @default.
- W4361954317 hasRelatedWork W4295154856 @default.
- W4361954317 hasRelatedWork W4297472852 @default.
- W4361954317 isParatext "false" @default.
- W4361954317 isRetracted "false" @default.
- W4361954317 workType "article" @default.