Matches in SemOpenAlex for { <https://semopenalex.org/work/W4361958082> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W4361958082 abstract "<div>AbstractPurpose:<p>Dose-dense methotrexate-vinblastine-adriamycin-cisplatin (ddMVAC) and gemcitabine-cisplatin (GC) are accepted neoadjuvant regimens for muscle-invasive bladder cancer. The aim of this study was to validate the score from a coexpression extrapolation (COXEN) algorithm–generated gene expression model (GEM) as a biomarker in patients undergoing radical cystectomy.</p>Patients and Methods:<p>Eligibility included cT2-T4a N0 M0, urothelial bladder cancer, ≥ 5 mm of viable tumor, cisplatin eligible, with plan for cystectomy; 237 patients were randomized between ddMVAC, given every 14 days for four cycles, and GC, given every 21 days for four cycles. The primary objective assessed prespecified dichotomous treatment-specific COXEN score as predictive of pT0 rate or ≤ pT1 (downstaging) at surgery.</p>Results:<p>Among 167 evaluable patients, the OR for pT0 with the GC GEM score in GC-treated patients was 2.63 [<i>P</i> = 0.10; 95% confidence interval (CI), 0.82–8.36]; for the ddMVAC COXEN GEM score with ddMVAC treatment, the OR was 1.12 (<i>P</i> = 0.82, 95% CI, 0.42–2.95). The GC GEM score was applied to pooled arms (GC and ddMVAC) for downstaging with an OR of 2.33 (<i>P</i> = 0.02; 95% CI, 1.11–4.89). In an intention-to-treat analysis of eligible patients (<i>n</i> = 227), pT0 rates for ddMVAC and GC were 28% and 30% (<i>P</i> = 0.75); downstaging was 47% and 40% (<i>P</i> = 0.27), respectively.</p>Conclusions:<p>Treatment-specific COXEN scores were not significantly predictive for response to individual chemotherapy treatment. The COXEN GEM GC score was significantly associated with downstaging in the pooled arms. Additional biomarker development is planned.</p></div>" @default.
- W4361958082 created "2023-04-05" @default.
- W4361958082 creator A5000189456 @default.
- W4361958082 creator A5015887484 @default.
- W4361958082 creator A5020183452 @default.
- W4361958082 creator A5034219225 @default.
- W4361958082 creator A5034947059 @default.
- W4361958082 creator A5041043417 @default.
- W4361958082 creator A5044876102 @default.
- W4361958082 creator A5047940829 @default.
- W4361958082 creator A5048604566 @default.
- W4361958082 creator A5049622431 @default.
- W4361958082 creator A5059536506 @default.
- W4361958082 creator A5060006096 @default.
- W4361958082 creator A5069739807 @default.
- W4361958082 creator A5072152051 @default.
- W4361958082 creator A5082421872 @default.
- W4361958082 creator A5083920381 @default.
- W4361958082 creator A5088312939 @default.
- W4361958082 date "2023-03-31" @default.
- W4361958082 modified "2023-09-26" @default.
- W4361958082 title "Data from A Randomized Phase II Study of Coexpression Extrapolation (COXEN) with Neoadjuvant Chemotherapy for Bladder Cancer (SWOG S1314; NCT02177695)" @default.
- W4361958082 doi "https://doi.org/10.1158/1078-0432.c.6531165.v1" @default.
- W4361958082 hasPublicationYear "2023" @default.
- W4361958082 type Work @default.
- W4361958082 citedByCount "0" @default.
- W4361958082 crossrefType "posted-content" @default.
- W4361958082 hasAuthorship W4361958082A5000189456 @default.
- W4361958082 hasAuthorship W4361958082A5015887484 @default.
- W4361958082 hasAuthorship W4361958082A5020183452 @default.
- W4361958082 hasAuthorship W4361958082A5034219225 @default.
- W4361958082 hasAuthorship W4361958082A5034947059 @default.
- W4361958082 hasAuthorship W4361958082A5041043417 @default.
- W4361958082 hasAuthorship W4361958082A5044876102 @default.
- W4361958082 hasAuthorship W4361958082A5047940829 @default.
- W4361958082 hasAuthorship W4361958082A5048604566 @default.
- W4361958082 hasAuthorship W4361958082A5049622431 @default.
- W4361958082 hasAuthorship W4361958082A5059536506 @default.
- W4361958082 hasAuthorship W4361958082A5060006096 @default.
- W4361958082 hasAuthorship W4361958082A5069739807 @default.
- W4361958082 hasAuthorship W4361958082A5072152051 @default.
- W4361958082 hasAuthorship W4361958082A5082421872 @default.
- W4361958082 hasAuthorship W4361958082A5083920381 @default.
- W4361958082 hasAuthorship W4361958082A5088312939 @default.
- W4361958082 hasBestOaLocation W43619580822 @default.
- W4361958082 hasConcept C121608353 @default.
- W4361958082 hasConcept C126322002 @default.
- W4361958082 hasConcept C126894567 @default.
- W4361958082 hasConcept C143998085 @default.
- W4361958082 hasConcept C2775910329 @default.
- W4361958082 hasConcept C2776694085 @default.
- W4361958082 hasConcept C2777132456 @default.
- W4361958082 hasConcept C2778239845 @default.
- W4361958082 hasConcept C2778292576 @default.
- W4361958082 hasConcept C2780258809 @default.
- W4361958082 hasConcept C2780352672 @default.
- W4361958082 hasConcept C44249647 @default.
- W4361958082 hasConcept C530470458 @default.
- W4361958082 hasConcept C71924100 @default.
- W4361958082 hasConcept C90924648 @default.
- W4361958082 hasConceptScore W4361958082C121608353 @default.
- W4361958082 hasConceptScore W4361958082C126322002 @default.
- W4361958082 hasConceptScore W4361958082C126894567 @default.
- W4361958082 hasConceptScore W4361958082C143998085 @default.
- W4361958082 hasConceptScore W4361958082C2775910329 @default.
- W4361958082 hasConceptScore W4361958082C2776694085 @default.
- W4361958082 hasConceptScore W4361958082C2777132456 @default.
- W4361958082 hasConceptScore W4361958082C2778239845 @default.
- W4361958082 hasConceptScore W4361958082C2778292576 @default.
- W4361958082 hasConceptScore W4361958082C2780258809 @default.
- W4361958082 hasConceptScore W4361958082C2780352672 @default.
- W4361958082 hasConceptScore W4361958082C44249647 @default.
- W4361958082 hasConceptScore W4361958082C530470458 @default.
- W4361958082 hasConceptScore W4361958082C71924100 @default.
- W4361958082 hasConceptScore W4361958082C90924648 @default.
- W4361958082 hasLocation W43619580821 @default.
- W4361958082 hasLocation W43619580822 @default.
- W4361958082 hasOpenAccess W4361958082 @default.
- W4361958082 hasPrimaryLocation W43619580821 @default.
- W4361958082 hasRelatedWork W2122063636 @default.
- W4361958082 hasRelatedWork W2603025253 @default.
- W4361958082 hasRelatedWork W2768838532 @default.
- W4361958082 hasRelatedWork W2782762180 @default.
- W4361958082 hasRelatedWork W2907995139 @default.
- W4361958082 hasRelatedWork W2946011640 @default.
- W4361958082 hasRelatedWork W2999610262 @default.
- W4361958082 hasRelatedWork W3202515919 @default.
- W4361958082 hasRelatedWork W4361914345 @default.
- W4361958082 hasRelatedWork W4361970994 @default.
- W4361958082 isParatext "false" @default.
- W4361958082 isRetracted "false" @default.
- W4361958082 workType "article" @default.