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• W4361959021 abstract "<div>Abstract<p><b>Purpose:</b> Mixed lineage leukemia (MLL) is a histone methyltransferase that activates gene transcription and associates with menin. In multiple endocrine neoplasia type 1 (Men1), a mutation of menin caused decreased expression of the <i>p27^Kip1</i> and <i>p18^Ink4C</i> genes and deregulated cell growth. We hypothesized that the same pathway might be involved in sporadic pituitary adenomas.</p><p><b>Experimental Design:</b> mRNA levels for MLL, Men1, p27^Kip1, and p18^Ink4C were measured in specimens of several sporadic pituitary adenomas, and a search for clinical parameters revealed that octreotide treatment affected the level of expression of some genes tested. To study molecular mechanisms, we cloned and characterized the MLL promoter region and used small interfering RNA for MLL and specific inhibitors for signal transduction pathways.</p><p><b>Results:</b> A strong correlation between MLL and p27^Kip1 mRNA levels was observed in prolactinomas and growth hormone–secreting adenomas, and these levels were attenuated except in growth hormone–secreting adenomas treated with a somatostatin analogue, octreotide. Conversely, the patients treated with octreotide showed high levels of MLL-p27^Kip1 mRNA. Experiments <i>in vitro</i> showed that octreotide increased MLL and p27^Kip1 protein and mRNA levels, and overexpression of MLL induced a marked increase in p27^Kip1promoter activity. Furthermore, octreotide stimulated the promoter activity of the <i>MLL</i> gene through phosphatidylinositol 3-kinase/Akt and mitogen-activated protein kinase pathways. In addition, incubation with an inhibitor for methyltransferase, MTA, and knockdown of MLL completely inhibited the octreotide-induced expression of p27^Kip1.</p><p><b>Conclusions:</b> The MLL-p27^Kip1 pathway was down-regulated in the pituitary adenomas, and octreotide increased the p27^Kip1 level, at least in part, by sequential transcriptional stimulation of the <i>MLL</i> and <i>p27^Kip1</i> genes through phosphatidylinositol 3-kinase/Akt and mitogen-activated protein kinase pathways.</p></div>" @default.
• W4361959021 created "2023-04-05" @default.
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• W4361959021 date "2023-03-31" @default.
• W4361959021 modified "2023-09-25" @default.
• W4361959021 title "Data from Transcriptional Activation of the Mixed Lineage Leukemia–p27^Kip1 Pathway by a Somatostatin Analogue" @default.
• W4361959021 doi "https://doi.org/10.1158/1078-0432.c.6518025.v1" @default.
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