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• W4361959317 abstract "<div>AbstractPurpose:<p>Inefficient homing of adoptively transferred cytotoxic T lymphocytes (CTLs) to tumors is a major limitation to the efficacy of adoptive cellular therapy (ACT) for cancer. However, through fucosylation, a process whereby fucosyltransferases (FT) add fucose groups to cell surface glycoproteins, this challenge may be overcome. Endogenously fucosylated CTLs and <i>ex vivo</i> fucosylated cord blood stem cells and regulatory T cells were shown to preferentially home to inflamed tissues and marrow. Here, we show a novel approach to enhance CTL homing to leukemic marrow and tumor tissue.</p>Experimental Design:<p>Using the enzyme FT-VII, we fucosylated CTLs that target the HLA-A2–restricted leukemia antigens CG1 and PR1, the HER2-derived breast cancer antigen E75, and the melanoma antigen gp-100. We performed <i>in vitro</i> homing assays to study the effects of fucosylation on CTL homing and target killing. We used <i>in vivo</i> mouse models to demonstrate the effects of <i>ex vivo</i> fucosylation on CTL antitumor activities against leukemia, breast cancer, and melanoma.</p>Results:<p>Our data show that fucosylation increases <i>in vitro</i> homing and cytotoxicity of antigen-specific CTLs. Furthermore, fucosylation enhances <i>in vivo</i> CTL homing to leukemic bone marrow, breast cancer, and melanoma tissue in NOD/SCID gamma (NSG) and immunocompetent mice, ultimately boosting the antitumor activity of the antigen-specific CTLs. Importantly, our work demonstrates that fucosylation does not interfere with CTL specificity.</p>Conclusions:<p>Together, our data establish <i>ex vivo</i> CTL fucosylation as a novel approach to improving the efficacy of ACT, which may be of great value for the future of ACT for cancer.</p></div>" @default.
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• W4361959317 date "2023-03-31" @default.
• W4361959317 modified "2023-09-25" @default.
• W4361959317 title "Data from Fucosylation Enhances the Efficacy of Adoptively Transferred Antigen-Specific Cytotoxic T Lymphocytes" @default.
• W4361959317 doi "https://doi.org/10.1158/1078-0432.c.6528759" @default.
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