FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4361960004> ?p ?o ?g. }

• W4361960004 abstract "<div>AbstractPurpose:<p>Increased availability of next-generation sequencing has allowed for the genomic characterization of a variety of pediatric tumors, although genomic determinants of response to treatment remain largely unknown. We sought to evaluate the genomic landscape and genomic determinants of clinical outcomes in rhabdomyosarcoma (RMS).</p>Experimental Design:<p>Of 29,067 patients who underwent genomic profiling at our institution using a 468-gene oncopanel with complete records, 87 had RMS, of whom 22 were fusion positive. The 10 most common genetic alterations were associated with locoregional control (LC), disease-free survival (DFS), and overall survival (OS). Tumor mutational burden (TMB), defined as the total number of somatic nonsynonymous mutations normalized to the number of sequenced megabases, was also associated with clinical outcomes.</p>Results:<p>Median age at diagnosis was 16.4 years and median follow-up, 2.1 years. Patients with fusion-negative RMS had more genomic alterations and a higher TMB than those with fusion-positive RMS (mean number of genomic alterations, 6.0 vs. 2.9; <i>P</i> = 0.007 and mean TMB, 2.6 vs. 1.0; <i>P</i> = 0.01). Genetic alterations in <i>TP53</i> were associated with worse OS (<i>P</i> = 0.03). High TMB (defined as the top quartile ≥ 2.8) was associated with worse LC (<i>P</i> = 0.05), DFS (<i>P</i> = 0.04), and OS (<i>P</i> = 0.01), with significance retained on multivariable analysis after controlling for risk group, fusion status, and receipt of chemotherapy as per pediatric protocols.</p>Conclusions:<p>High TMB was associated with worse clinical outcomes in patients with RMS. With further validation, TMB and other genomic classifiers may be combined with traditional clinicopathologic risk factors to guide risk stratification and ultimately treatment decisions.</p></div>" @default.
• W4361960004 created "2023-04-05" @default.
• W4361960004 creator A5001610703 @default.
• W4361960004 creator A5043898160 @default.
• W4361960004 creator A5052753028 @default.
• W4361960004 creator A5065142888 @default.
• W4361960004 creator A5074725191 @default.
• W4361960004 creator A5080725919 @default.
• W4361960004 date "2023-03-31" @default.
• W4361960004 modified "2023-09-25" @default.
• W4361960004 title "Data from Genomic Determinants of Clinical Outcomes in Rhabdomyosarcoma" @default.
• W4361960004 doi "https://doi.org/10.1158/1078-0432.c.6529422" @default.
• W4361960004 hasPublicationYear "2023" @default.
• W4361960004 type Work @default.
• W4361960004 citedByCount "0" @default.
• W4361960004 crossrefType "posted-content" @default.
• W4361960004 hasAuthorship W4361960004A5001610703 @default.
• W4361960004 hasAuthorship W4361960004A5043898160 @default.
• W4361960004 hasAuthorship W4361960004A5052753028 @default.
• W4361960004 hasAuthorship W4361960004A5065142888 @default.
• W4361960004 hasAuthorship W4361960004A5074725191 @default.
• W4361960004 hasAuthorship W4361960004A5080725919 @default.
• W4361960004 hasBestOaLocation W43619600042 @default.
• W4361960004 hasConcept C104317684 @default.
• W4361960004 hasConcept C111829193 @default.
• W4361960004 hasConcept C126322002 @default.
• W4361960004 hasConcept C141231307 @default.
• W4361960004 hasConcept C143998085 @default.
• W4361960004 hasConcept C149904235 @default.
• W4361960004 hasConcept C54355233 @default.
• W4361960004 hasConcept C71924100 @default.
• W4361960004 hasConcept C86803240 @default.
• W4361960004 hasConceptScore W4361960004C104317684 @default.
• W4361960004 hasConceptScore W4361960004C111829193 @default.
• W4361960004 hasConceptScore W4361960004C126322002 @default.
• W4361960004 hasConceptScore W4361960004C141231307 @default.
• W4361960004 hasConceptScore W4361960004C143998085 @default.
• W4361960004 hasConceptScore W4361960004C149904235 @default.
• W4361960004 hasConceptScore W4361960004C54355233 @default.
• W4361960004 hasConceptScore W4361960004C71924100 @default.
• W4361960004 hasConceptScore W4361960004C86803240 @default.
• W4361960004 hasLocation W43619600041 @default.
• W4361960004 hasLocation W43619600042 @default.
• W4361960004 hasOpenAccess W4361960004 @default.
• W4361960004 hasPrimaryLocation W43619600041 @default.
• W4361960004 hasRelatedWork W1987798892 @default.
• W4361960004 hasRelatedWork W1991523530 @default.
• W4361960004 hasRelatedWork W1994052653 @default.
• W4361960004 hasRelatedWork W1999897327 @default.
• W4361960004 hasRelatedWork W2002128513 @default.
• W4361960004 hasRelatedWork W2057531380 @default.
• W4361960004 hasRelatedWork W2100964397 @default.
• W4361960004 hasRelatedWork W2109303963 @default.
• W4361960004 hasRelatedWork W2126290201 @default.
• W4361960004 hasRelatedWork W2092874662 @default.
• W4361960004 isParatext "false" @default.
• W4361960004 isRetracted "false" @default.
• W4361960004 workType "article" @default.